cytopathic effects
Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects
... Methods: Primary astrocytes were isolated from wild-type (WT) and interferon alpha receptor knock out (IFNAR −/− ) mice and infected with neurotropic flaviviruses. Viral replication and spread, IFN induction and ...
15
Differential susceptibility of naive and memory CD4+ T cells to the cytopathic effects of infection with human immunodeficiency virus type 1 strain LAI.
... reflect differences with other HIV-1 isolates, particularly pri- mary isolates. It is now clear that isolates from different in- fected individuals show variation in biological properties in- cluding rates of replication ...
9
Astrocytes Survive Chronic Infection and Cytopathic Effects of the ts1 Mutant of the Retrovirus Moloney Murine Leukemia Virus by Upregulation of Antioxidant Defenses
... In our hands, primary astrocytes and continuous astrocyte cultures were infected with ts1 at a multiplicity of infection of 5 to 10, to ensure that all cells were infected when the inocu- lum was added. Under these ...
12
bc1-2 expression facilitates human immunodeficiency virus type-1 mediated cytopathic effects during acute spreading infections.
... The cytopathic effects (CPE) resulting from the infection of CD4 1 T cells by human immunodeficiency virus (HIV) have generally been characterized as single-cell killing associated with apoptosis and/or the ...
7
Immune Suppression Uncovers Endogenous Cytopathic Effects of the Hepatitis B Virus
... direct cytopathic effects in severely immune compromised hosts, we have infected severe combined immune deficient mice (uPA-SCID), harboring human liver cells, with ...directly cytopathic in ...
11
Mutations of a Residue within the Polyproline-Rich Region of Env Alter the Replication Rate and Level of Cytopathic Effects in Chimeric Avian Retroviral Vectors
... Previous attempts to extend the host range of the avian sarcoma/leukosis virus (ASLV)-based RCASBP vectors produced two viral vectors, RCASBP M2C (4070A) and RCASBP M2C (797-8), which replicate using the ampho- tropic ...
10
Label-Free Digital Holo-tomographic Microscopy Reveals Virus-Induced Cytopathic Effects in Live Cells
... ABSTRACT Cytopathic effects (CPEs) are a hallmark of infections. CPEs are difficult to observe due to phototoxicity from classical light microscopy. We report distinct patterns of virus infections in live ...
14
Alteration of intracellular potassium and sodium concentrations correlates with induction of cytopathic effects by human immunodeficiency virus.
... direct cytopathic effects (CPE) of HIV contribute to CD4 1 T-cell depletion in ...selective cytopathic capacity in vivo could explain, in part, the selective loss of CD4 1 cells in ...
10
Demyelination and cytopathic effects in cultures of mammalian dorsal root ganglia infected with encephalomyocarditis virus.
... SHAHAR, AND RACHEL MONZAIN Israel Institute for Biological Research, Ness-Ziona, Israel Replication of encephalomyocarditis virus and its cytopathic effects were studied in myelinated cu[r] ...
10
Coxsackievirus Preferentially Replicates and Induces Cytopathic Effects in Undifferentiated Neural Progenitor Cells
... Enteroviruses, including coxsackieviruses, exhibit significant tropism for the central nervous system, and these viruses are commonly associated with viral meningitis and encephalitis. Previously, we described the ...
15
Changes in the cytopathic effects of human immunodeficiency virus type 1 associated with a single amino acid alteration in the ectodomain of the gp41 transmembrane glycoprotein.
... However, the cytopathic effects associated with infection by the mutant virus were altered, with a marked attenuation of syncytium formation and a significant delay in single-cell lysis [r] ...
7
Demonstration of two distinct cytopathic effects with syncytium formation-defective human immunodeficiency virus type 1 mutants.
... BSC-40 cells infected with vaccinia virus recombinants revealed no differences in kinetics of cleavage, cell surface expression, or CD4 binding capacity of the mutant and parental envelo[r] ...
8
Correlation of specific virus-astrocyte interactions and cytopathic effects induced by ts1, a neurovirulent mutant of Moloney murine leukemia virus.
... In summary, the study reported here shows that the most important characteristics of tsl infection in primary astrocyte cultures are i cytopathogenicity of virus infection, ii high level[r] ...
11
Gamma Interferon Is a Major Suppressive Factor Produced by Activated Human Peripheral Blood Lymphocytes That Is Able To Inhibit Foamy Virus-Induced Cytopathic Effects
... Foamy viruses (FVs) are members of the Spumavirus genus of the family Retroviridae and are widely distributed among mammals, e.g., monkeys, cows, and cats (10, 25). Although humans are not natural hosts, accidental ...
5
Scanning electron microscopic studies of virus-infected cells. I. Cytopathic effects and maturation of vesicular stomatitis virus in L2 cells.
... The unique stereoscopic images of the surfaces of infected cells have revealed that virions bud both singly and in radiating clusters, virions develop both from the plasma membrane over [r] ...
8
Structure and Cytopathic Effects of Nelson Bay Virus
... The characteristic perinuclear inclusions seen in reovirus-infected cells 5, 13 were not seen in NBV-infected syncytia which showed intranuclear fluorescence in contrast to the intense p[r] ...
7
Impact of cell culture sensitivity and virus concentration on rapid detection of herpes simplex virus by cytopathic effects and immunoperoxidase staining
... In this study, mink lung, rabbit kidney, MRC-5, and Vero cells were compared for reisolation of herpes simplex virus from clinical specimens in which viral infectivity titers were concur[r] ...
5
Cytopathic effects induced by Epstein-Barr virus replication in epithelial nasopharyngeal carcinoma hybrid cells.
... 3555 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest NPC-KT cl.S61, a subclone derived from an epithelial-nasopharyngeal carcinoma hybrid cell line NPC-KT, showed cytop[r] ...
5
Monovalent cation metabolism and cytopathic effects of poliovirus-infected HeLa cells.
... A net loss in the monovalent cation activity of infected cells was indicated by the loss of cell water as reflected in a decrease in cell volume and an increase in cell density.. In spit[r] ...
6
Replication and cytopathic effects of ovine lentivirus strains in alveolar macrophages correlate with in vivo pathogenicity.
... In contrast, ovine lentivirus isolate 85/34 produced early peak virus titers and caused rapid fusion and lysis of both macrophages and synovial cells.. Ovine lentivirus isolates which we[r] ...
5