cytoskeletal organization
Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation
... of cytoskeletal organization and focal adhesion turnover correlate to tumorigenesis and epithelial-mesenchymal transition (EMT), the latter process accompanied by the loss of epithelial markers and the gain ...
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Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration
... Results: Here we use data from a genome-wide RNAi morphology screen in Drosophila melanogaster cells together with bioinformatics to identify 26 new regulators of morphology and cytoskeletal organization in ...
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Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat
... junctional remodeling in which junctional assembly and disassembly are activated in the same cellular domain, whereas other domains are largely quiescent. These behaviors could provide a mechanism that allows cells to ...
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Actin Cytoskeletal Organization in Drosophila Germline Ring Canals Depends on Kelch Function in a Cullin-RING E3 Ligase
... addition, cytoskeletal struc- tural proteins, such as the F-actin binding protein Filamin, have been shown to be targets of UPS-mediated destruction (Razinia et ...
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Tristetraprolin functions in cytoskeletal organization during mouse oocyte maturation
... Tristetraprolin (TTP), a member of TIS11 family containing CCCH tandem zinc finger, is one of the best characterized RNA-binding proteins. However, to date, the role of TTP in mammalian oocytes remains completely ...
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In Vitro Biocompatibility Assessment of Microstructured and Nanostructured Surfaces for Medical Device Applications.
... 174 Biological evaluation of tantalum coatings was conducted using hBMSCs to evaluate the effects of surface topography on cellular response for orthopaedic and dental applications. Cell adhesion of hBMSCs after 24 hour ...
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Electrical activity, growth cone motility and the cytoskeleton
... the organization of its cytoskeleton, which is composed of microtubules and microfilaments (Yamada et ...this cytoskeletal organization with cytoskeletal drugs such as cytochalasin, nocodazole ...
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RacB Regulates Cytoskeletal Function in Dictyostelium spp.
... whether each of these genes has a unique function or to what extent they play redundant roles in actin cytoskeletal organization. To investigate the specific function of RacB, we have conditionally ...
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Dishevelled associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis
... Small GTPases, including RhoA, Rac1 and Cdc42 all play essential roles in regulating actin cytoskeletal organization (Jenny and Mlodzik, 2006). RhoA has been proposed to be an effector of Daam1 in actin ...
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Cytoskeletal mechanisms responsible for invasive migration of neoplastic cells
... Besides “classical” SF-induced EMT described above, there are several examples of similar transformations of cell shape and cytoskeletal organization developing without application of spe- cial inducing ...
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Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea
... of cytoskeletal structures on cell surface mechanical ...the cytoskeletal organization of developing sensory and non-sensory cells, and used pharmacological modulation of cytoskeletal elements ...
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Cytoskeletal Changes in Non-Apoptotic Cell Death
... In order to determine the effect of Zn on disruption of actin cytoskeleton of cancer Hep-2 cells, we measured F- and G-actin levels during 12h incubation with 300 μ M ZnSO 4 . Fig. 3 illustrates that F-actin pools ...
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Morphology of the Trypanosome Bilobe, a Novel Cytoskeletal Structure
... To determine whether this arm next to the FAZ filament con- tained other bilobe components, we considered two other known structural protein components of the bilobe—TbLRRP1 and TbCentrin4 (35, 41). Endogenous TbLRRP1 ...
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Contribution of cytoskeletal elements to the axonal mechanical properties
... Hertz contact theory provides only an estimate of the elastic properties of the axon, but can be used to compare the effects of disrupting the cytoskeletal elements, but it should be noted that a more complete ...
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A constitutive model for cytoskeletal contractility of smooth muscle cells
... three-dimensional cytoskeletal network in response to compression [9], shear [10] and in situ dynamic loading [11] have been studied numerically, based on the modelling ...
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BCR/ABL induces multiple abnormalities of cytoskeletal function
... of cytoskeletal function is abnor- mal, in that the affinity of b 1 integrins for fibronectin is al- tered in CML ...of cytoskeletal function were shown to require BCR/ABL tyrosine kinase ...of ...
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Involvement of Cytoskeletal Components in BK Virus Infectious Entry
... Having successfully crossed the plasma membrane, BK virus now has to traverse the cytoplasm and deliver its genome to the host cell nucleus for replication. The parasitic nature and sim- plicity of viruses account for ...
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Folding and Assembly of Cytoskeletal Proteins Under Force - From Single Molecule Studies of Dystrophin to Studies of Intact Cells
... actin cytoskeletal network are a likely way cells read mechanical signals from their ...the cytoskeletal network to spectrin function was also demonstrated in mutant, ...
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Retention of the glycoprotein IIb IIIa complex in the isolated platelet cytoskeleton Effects of separable assembly of platelet pseudopodal and contractile cytoskeletons
... complete cytoskeletal core (pseudopodal and contractile elements) while PMA activation forms only an actin plus actin-binding protein pseudopodal ...blocks cytoskeletal development if PMA activated. ...
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Cytoskeletal mechanisms of ooplasmic segregation in annelid eggs
... Ooplasmic segregation in Theromyzon has been more exten- sively examined by Fernandez et al. (1998). These authors have proposed that ooplasmic segregation (teloplasm formation) in this animal consists of three steps. ...
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