Cytotoxic T cell
Case Report Solitary Epstein-Barr virus-positive cytotoxic T cell lymphoproliferative disease in stomach mimicking extranodal NK/T cell lymphoma
... scopic findings in dicateda suspected diagno- sis of gastric cancer. During the operation of a radical gastrectomy, the size of lesion was found to be 5 × 4 × 3 cm, locating at gastric cardia and gastric body with ...
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Human cytotoxic T-cell memory: long-lived responses to vaccinia virus.
... Peripheral T lymphocytes can be classified into two groups: naive and memory T ...of T-cell memory in ...memory cytotoxic T cells in adults who had been immunized against ...
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Protection of Hepatocytes from Cytotoxic T Cell Mediated Killing by Interferon-Alpha
... Lines were generated from the PBMC of healthy donors. Approximately 106 10 6 cells were pulsed with 10 mM specific peptide solution for 1 hour before culturing for 12 –14 days in medium containing IL-2 (50 U/ml). Freshly ...
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Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus.
... of T-cell receptors ...(58). T-cell responses in an individual to a foreign protein from either a viral or a nonviral source is generally restricted to a few but some times only one immu- ...
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T cells presenting viral antigens or autoantigens induce cytotoxic T cell anergy
... + cytotoxic T cell (CTL) tolerance to the PCD autoantigen, ...that T cells also express ...to T cells expressing CDR2. This was a general phenomenon, as T cells presenting ...
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Functional management of an antiviral cytotoxic T-cell response.
... secondary T-cell responses after in vivo restimulation, indicating that the minor specificities present during the primary response were largely purged from the repertoire during the establishment of CTL ...
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Induction of Foot-and-Mouth Disease Virus-Specific Cytotoxic T Cell Killing by Vaccination
... potential T cell epitopes are not limited to the structural proteins, where most of the immune-driven diversity is located ...the T cell epitopes are linear and extremely small (8 to 12 amino ...
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CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection.
... In addition, we have shown that CD4+ T cells are not necessary for the induction of a primary LCMV-specific CD8+ CTL response in vivo and that CD4-depleted mice can effectively control a[r] ...
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Virus-Specific CD4+ and CD8+ Cytotoxic T-Cell Responses and Long-Term T-Cell Memory in Individuals Vaccinated against Polio
... CD8 T cells (17, 21, 23, ...PV-specific T cells in protective immunity in these mice could not be ...CD4 T cells into PVR-trans- genic mice that are susceptible to PV infection showed that CD4 ...
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T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone
... ⫹ T-cell clones derived from HIV-1-infected persons were used in these studies and were characterized as effective CD8 ⫹ T-cell clones (EC) or ineffective CD8 ⫹ T-cell clones ...
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Viral Evolution and Cytotoxic T Cell Restricted Selection in Acute Infant HIV-1 Infection
... Antiretroviral therapy-naive HIV-1 infected infants experience poor viral containment and rapid disease progression compared to adults. Viral factors (e.g. transmitted cytotoxic T- lymphocyte (CTL) escape ...
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Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T cell clones.
... IL-2-stimulated normal lymphocytes or leukemic cells from HLA-A 1 -positive patients were lysed only by the HA- 3 mH antigen-specific CTL clone (HLA-A I restricted), and IL[r] ...
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Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV resistant prostitutes in Nairobi
... PBMCs were separated from 10–15 ml heparinized blood, and pep- tide-stimulated cultures were established using peptide epitopes se- lected according to the donor’s class I HLA type (4). In brief, the cells were pulsed as ...
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Human T-cell leukemia virus type I infection of CD4+ or CD8+ cytotoxic T-cell clones results in immortalization with retention of antigen specificity.
... Infection of heterogeneous cultures of peripheral, cord blood, or bone marrow lymphocytes results in the outgrowth of a population of rapidly proliferating cells which demonstrate a decr[r] ...
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HLA identical leukemia cells and T cell growth factor activate cytotoxic T cell recognition of minor locus histocompatibility antigens in vitro
... and cell-mediated lysis (CML) responses between the patient's remission (pretransplant) and donor's lymphocytes were ...any cytotoxic cells able to destroy the HLA identical leukemic ...in T ...
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Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism
... In cytotoxic T cells (CTL), Akt, also known as protein kinase B, is activated by the T cell antigen receptor (TCR) and the cytokine interleukin 2 ...control cell metabolism in many ...
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In Situ Evolution of Virus-Specific Cytotoxic T Cell Responses in the Lung
... chi, forming dense clusters of infected cells (Fig. 4D). Closer mag- nification revealed the most intensive infection of bronchial epi- thelial cells in areas where the infection also extended to lung parenchymal cells. ...
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The generation of cytotoxic T cell epitopes and their generation for cancer immunotherapy
... natural T cell immunity against CML, which interestingly appeared to be multi-epitopic [73,74] (see also below), was either not [73] or hardly [74] found to be directed towards BCR-ABL breakpoint ...the ...
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Dynamics of the Cytotoxic T Cell Response to a Model of Acute Viral Infection
... ⫹ T cell clones (also known as cy- totoxic T lymphocytes, or CTLs) become activated and expand as they recognize and eliminate infected host cells (1, ...a T cell clone is determined by ...
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Cytotoxic T-cell response to respiratory syncytial virus in mice.
... We report here the finding of major histocompatibility complex-restricted, RSV-specific memory cytotoxic T cells in the spleens of BALB/c and C57BL mice after intranasal infection; these[r] ...
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