cytotoxic T-lymphocyte
Cytotoxic T lymphocyte antigen 4 and immune checkpoint blockade
... Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a regulatory molecule that suppresses T cell effector function following initial activation by costimulatory ...increase T cell function and ...
8
Prospective study of cytotoxic T lymphocyte responses to influenza and antibodies to human T lymphotropic virus III in homosexual men Selective loss of an influenza specific, human leukocyte antigen restricted cytotoxic T lymphocyte response in human T lymphotropic virus III positive individuals with symptoms of acquired immunodeficiency syndrome and in a patient with acquired immunodeficiency syndrome
... weak cytotoxic T lymphocyte responses to flu- ...flu-self cytotoxic T lymphocyte responses and antibodies to ...detectable cytotoxic T lymphocyte activity to ...
7
Quantitative study of cytotoxic T-lymphocyte immunotherapy for nasopharyngeal carcinoma
... infuse cytotoxic T-lymphocyte (CTL) lines several times by intravenous injection, but it is difficult by laboratory research to investigate the relationship between treatment time-point, the amount ...
12
Common Antiviral Cytotoxic T-Lymphocyte Epitope for Diverse Arenaviruses
... Members of the Arenaviridae family have been isolated from mammalian hosts in disparate geographic locations, leading to their grouping as Old World types (i.e., lymphocytic choriomeningitis virus [LCMV], Lassa fever ...
6
The monoclonal antibody to cytotoxic T lymphocyte antigen 4, ipilimumab, in the treatment of melanoma
... The rationale for studying immunotherapies is based on evidence of spontaneous remissions and observed response to biological agents that stimulate the immune system. Cytotoxic T lymphocyte antigen 4 ...
8
Anti-cytotoxic T lymphocyte antigen-4 antibodies in melanoma
... anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) antibody, is a new generation immunotherapeutic agent that has shown activity in terms of disease free and overall survival in metastatic melanoma ...to ...
12
The neurotrophic hepatocyte growth factor attenuates CD8+ cytotoxic T-lymphocyte activity
... + T cell func- tions we used an established in vitro model of cytotoxic T-cell-dependent ...effector cytotoxic gp100-petide T cell receptor (Pmel-1) CD8 + T cells from naïve ...+ ...
10
The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon.
... virus-specific cytotoxic T-lymphocyte (CTL) activity in the cell population recovered by bronchoalveolar lavage is unimpaired, the prevalence of interleukin-4 (IL-4)-producing cells is increased, and ...
5
Correlation of Major Histocompatibility Complex Class I Downregulation with Resistance of Human T-Cell Leukemia Virus Type 1-Infected T Cells to Cytotoxic T-Lymphocyte Killing in a Rat Model
... Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) in infected individuals after a long incubation ...Tax-specific cytotoxic T-lymphocyte (CTL) lines from ...
10
Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins
... To date, some EBOV derived CD8 + T cell epitopes have been identified. Rao et al. identified a H-2 k -specific and two H-2 d -specific murine EBOV-GP CTL epitope by immunizing mice with a liposome encapsulated by ...
7
Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV 1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells
... ⫹ T cells that se- crete proinflammatory factors in the absence of CTL killing could promote viral replication following antigen ...ory T cells that are specific for variants of the immunotherapeutic ...⫹ ...
18
Simian virus 40 T antigen as a carrier for the expression of cytotoxic T-lymphocyte recognition epitopes.
... The results show that the translocated SV40 T antigen site I and the HSV gB CTL epitopes in the chimeric T antigens, when expressed in immortalized C57BL/6 B6 mouse kidney cells, were ef[r] ...
6
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity
... The localization of NPF proteins can focus Arp2/3 activity to distinct compartments within the cell, e.g., plasma membrane, cytoplasm, endocytic vesicles, or nucleus. This can give rise to specialized subcellular ...
16
Antiviral Antibodies Are Necessary To Prevent Cytotoxic T-Lymphocyte Escape in Mice Infected with a Coronavirus
... mice, while they diminish in BALB/b mice (Fig. 3D and E). In the absence of an anti-JHMV antibody response, CTL escape at epitope S510 is detected in all mice (Tables 1 and 2 and Fig. 4). This high rate of CTL escape is ...
8
Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation
... Student’s t test (a normal distribution of data points was assumed; variances were assessed, and if necessary an unpaired t test with Welch’s correction was applied) or with a 1-way ANOVA analysis followed ...
19
Vaccinia virus-specific human CD4+ cytotoxic T-lymphocyte clones.
... b Clones established by UV-inactivated vaccinia virus stimulation of PBL from a healthy donor were tested for their ability to lyse uninfected or vaccinia virus-infected autologous B-LCL[r] ...
7
Epitope-Dependent Avidity Thresholds for Cytotoxic T-Lymphocyte Clearance of Virus-Infected Cells
... CTL T-cell receptors (TCRs) trigger these functions when they specifically bind infected cell surface viral epitope/HLA class I molecule complexes. These are produced after trans- lated viral proteins are ...
8
Human Cytotoxic T-Lymphocyte Repertoire to Influenza A Viruses
... It is assumed that healthy adults may have had more than one exposure to influenza A virus because primary influenza A virus infections occur in early childhood (15). These primary natural infections in a nonimmune host ...
8
Cytotoxic T lymphocyte responses against melanocytes and melanoma
... CD8+ T cells were observed in high percentages in both tumor and vitiligo lesions, supportive of the hypothesis that vitiligo may not be uncoupled from anti-tumor effect, and even indi- cative of the success of ...
10
Cytotoxic T lymphocyte responses to Ras protein
... a t reduced tem perature (23-3 l^C) (376). RMA-S cells cultured a t reduced temperature express a high level of H-2/p2in heterodimers on their cell surface th at behave as if they are not occupied by ...
217