Cytotoxic T lymphocyte response
Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine.
... 5 0022-538X/94/$04.00+0 Copyright © 1994, American Society for Microbiology Induction of a Major Histocompatibility Complex Class IRestricted Cytotoxic T-Lymphocyte Response to a Highly [r] ...
9
Immunization with a Modified Vaccinia Virus Expressing Simian Immunodeficiency Virus (SIV) Gag-Pol Primes for an Anamnestic Gag-Specific Cytotoxic T-Lymphocyte Response and Is Associated with Reduction of Viremia after SIV Challenge
... monoclonal antibodies (MAbs) used in this study were directly coupled to flu- orescein isothiocyanate (FITC), phycoerythrin (PE), phycoerythrin-Texas red (ECD), or allophycocyanin (APC). The following MAbs were used: ...
8
A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia
... immune response in which donor-derived CTLs eliminate malignant cells of the recipient (4, ...GVL response, and expansion of mHAg-specific CTLs has been shown to precede clinical remission in relapsed CML ...
12
Comparative Analysis of Cytotoxic T Lymphocyte Response Induced by Dendritic Cells Loaded with Hepatocellular Carcinoma -Derived RNA or Cell Lysate
... effctor T cells such as Th1 and CTL against HCC cell lines, which was evidenced by a higher percentage of tumor cell killing, as well as higher IFN-γ secretion of CD4+ and CD8+ T cells in DCs loaded with ...
10
CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection.
... Figure 2 shows the LCMV-specific serum IgG subtype pro- files of both CD40L 1 / 1 and CD40L 2 / 2 mice. The predom- inant subtype was IgG2a at all time points in both sets of mice and constituted 70 to 90% of the total ...
7
Acute Resolving Woodchuck Hepatitis Virus (WHV) Infection Is Associated with a Strong Cytotoxic T-Lymphocyte Response to a Single WHV Core Peptide
... The splenocytes of the two WHV-negative control animals showed no degranulation response (0.3% to 0.4%) after stim- ulation with WHcAg-derived peptide pool 4 (Fig. 2C and D). Epitope mapping for WHV core-specific ...
8
Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection
... Analysis of the CTL response to multiple HCV epitopes. To iden- tify patients whose CTL responses to HCV-derived epitopes were strong enough to warrant CTL precursor frequency anal- ysis longitudinally by limiting ...
10
In Vivo Induction of a High-Avidity, High-Frequency Cytotoxic T-Lymphocyte Response Is Associated with Antiviral Protective Immunity
... The cytotoxic response induced against a lymphocytic choriomeningitis virus (LCMV) peptide linked to these microspheres was compared to the cyto- toxic T-lymphocyte (CTL) response ...
7
The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon.
... ducing IL-4 have been generated from IFN-g 2/2 mice that had recovered from infection with an H2N2 influenza A virus (11), but direct evidence for an acute Th1-Th2 switch in lym- phoid tissue has been more elusive (32). ...
5
Construction of Hybrid Gene of Hepatitis B Surface Antigen Carrying Heat-Stable Enterotoxin of Escherichia coli and Its Expression in Mammalian Cell Line
... immune response against the desired antigen [2, 3, 14, ...immune response, this study was undertaken in order to assess the feasibility of combining the features of both ...and cytotoxic T ...
7
Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV 1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells
... CTL response is composed of a multitude of ...⫹ T cells that se- crete proinflammatory factors in the absence of CTL killing could promote viral replication following antigen ...ory T cells that are ...
18
Anti-cytotoxic T lymphocyte antigen-4 antibodies in melanoma
... Approaches aimed at enhancement of the tumor specific response have provided proof for the rationale of immunotherapy in cancer, both in animal models and in humans. However, while many immunotherapeutic ...
12
Cytotoxic T lymphocyte antigen 4 and immune checkpoint blockade
... tional Response Evaluation Criteria in Solid Tumors (RECIST) would not be an effective way to monitor for responses in all patients, and alternative criteria, termed immune-related response criteria (irRC), ...
8
Quantitative study of cytotoxic T-lymphocyte immunotherapy for nasopharyngeal carcinoma
... BIS is an agent-based model for studying the interactions between cells of the innate and adaptive immune systems [10]. The BIS was created with three “zones” of activity to represent the separate locations in the body ...
12
Human Cytotoxic T-Lymphocyte Repertoire to Influenza A Viruses
... CTL response is restricted to a small number of proteins, as in the mouse system, or extends to a larger number of proteins and ...CTL response at the clonal level to epitopes on a wide variety of ...
8
Feasibility study of personalized peptide vaccination for metastatic recurrent triple negative breast cancer patients
... complete response; CT: computed tomography; CTL: cytotoxic T lymphocyte; ECOG: Eastern Cooperative Oncology Group; EGF-R: epidermal growth factor receptor; EZH2: enhancer of zeste homolog 2; ...
13
Tissue Dimensionality Influences the Functional Response of Cytotoxic T Lymphocyte-Mediated Killing of Targets
... functional response between the two configurations remains unaffected by the relatively short- lived ...functional response of killing arise from the different search efficiencies that emerge between the ...
12
Dynamics of a fractional order HBV infection model with capsids and CTL immune response
... immune response presented by cytotoxic T lymphocyte (CTL) cells is proposed and ...functional response and the fractional derivative is in the Caputo ...
15
Phase II study of vemurafenib followed by ipilimumab in patients with previously untreated BRAF-mutated metastatic melanoma
... overall response; CA, California; CI, confidence interval; CTLA-4, cytotoxic T-lymphocyte antigen 4; DOR, duration of response; DOSD, duration of stable disease; ECOG, Eastern ...
10
Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients.
... Of course, the possibilities of viral sequence variation (24), infection of immune privileged sites, and interference with the antigen-processing machinery of the cell also represent viral strategies to escape the immune ...
11