DAF, decay accelerating factor
Hantavirus Causing Hemorrhagic Fever with Renal Syndrome Enters from the Apical Surface and Requires Decay-Accelerating Factor (DAF/CD55)
... entry. Decay-accelerating factor (DAF)/CD55 is a GPI-anchored protein of the complement regulatory system and serves as a receptor for attachment to the apical cell surface for a number of ...
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Interaction with Coxsackievirus and Adenovirus Receptor, but Not with Decay-Accelerating Factor (DAF), Induces A-Particle Formation in a DAF-Binding Coxsackievirus B3 Isolate
... infect DAF-transfected rodent cells, despite efficient attachment to DAF on the cell ...to DAF does not necessarily lead to infection. Another DAF- binding enterovirus, echovirus 7, is ...
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Dynamin- and Lipid Raft-Dependent Entry of Decay-Accelerating Factor (DAF)-Binding and Non-DAF-Binding Coxsackieviruses into Nonpolarized Cells
... therapies. We previously demonstrated that ectopic overexpres- sion of angiopoietin-2 (Ang-2) compromises the benefits of anti- VEGF receptor (VEGFR) treatment in murine GBM models and that circulating Ang-2 levels in ...
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Protection Against Hyperacute Xenograft Rejection of Transgenic Rat Hearts Expressing Human Decay Accelerating Factor (DAF) Transplanted into Primates
... High level endothelial expression of human CD59 in an ex vivo model of xenograft rejection pro-. longs heart function[r] ...
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The Crystal Structure of a Coxsackievirus B3-RD Variant and a Refined 9-Angstrom Cryo-Electron Microscopy Reconstruction of the Virus Complexed with Decay-Accelerating Factor (DAF) Provide a New Footprint of DAF on the Virus Surface
... binds DAF, whereas the original CVB3-Nancy does not ...with DAF was interpreted with the crystal structure of a non-DAF-binding CVB3 strain (CVB3 strain M [CVB3-M] [Pro- tein Data Bank {PDB} ...
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Synthesis of aberrant decay accelerating factor proteins by affected paroxysmal nocturnal hemoglobinuria leukocytes
... (O-glycosylated) DAF protein was increased and soluble DAF protein was detected in the ...surface DAF-negative PMN and MNC from four patients with type II erythrocytes showed mixtures of the 3 kD ...
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Identification of a third component of complement binding glycoprotein of human platelets
... from decay accelerating factor (DAF), a complement regulatory protein previously identified on human platelet ...membranes. DAF and gp45-70 have complementary activity profiles inasmuch ...
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Focal and segmental glomerulosclerosis induced in mice lacking decay accelerating factor in T cells
... “permeability factor” ...mice, DAF-deficient T cells mounted an immune response to the local podocyte-bound heterologous IgG, resulting in clinical and pathological features of human ...
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Interaction with Decay-Accelerating Factor Facilitates Coxsackievirus B Infection of Polarized Epithelial Cells
... CB3-RD attachment to and infection of T84 monolayers are inhibited by anti-DAF antibody. On nonpolarized cells, CB3 interaction with CAR is inhibited by the anti-CAR monoclonal antibody RmcB, and interaction with ...
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Genetic and environmental effects in paroxysmal nocturnal hemoglobinuria: this little PIG A goes “Why? Why? Why?”
... Despite its rarity, PNH has been stud- ied by exceptional clinical and laborato- ry investigators, every era attracting a cohort of scientists to concentrate on a different aspect of the disease. Perhaps surprisingly, ...
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Novel Role for Decay-Accelerating Factor in Coxsackievirus A21-Mediated Cell Infectivity
... from DAF reached maximal levels at 15 min, with no further significant elution increase after this time ...from DAF was increased by gradually elevating the temperature from 4 to 42°C while maintaining a ...
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Increased expression of complement decay accelerating factor during activation of human neutrophils
... surface DAF from patients with paroxysmal nocturnal hemoglobulinuria failed to increase DAF ...that DAF deficiency in affected cells involves abnormal synthesis or packaging of DAF for ...
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Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment.
... for DAF while the E7 population consisted of a more homogeneous population of virions with a high affinity for ...to DAF, are distinguishable from CB2, CB4, and CB6 by their higher af- finities for ...
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Decay-Accelerating Factor Binding Determines the Entry Route of Echovirus 11 in Polarized Epithelial Cells
... occludin and between EV11-207 and occludin was quantified as described in Materials and Methods. As seen in steady-state polarized Caco-2 cells, a minority of DAF was found colocal- ized with occludin. Addition of ...
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Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury
... 2) DAF Treatment Alone: cells treated with nor- mal basal medium in the presence of 200 ng/ml of recom- binant human DAF for 24 hours; 3) Hypoxia (NaCN): cells exposed to ...human DAF for 24 ...
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Decay accelerating factor protects human tumor cells from complement mediated cytotoxicity in vitro
... the decay- accelerating factor (DAF), a membrane regulatory protein that protects blood cells from autologous complement ...While DAF was undetectable among neuroblastomas, it was ...
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Markedly enhanced susceptibility to experimental autoimmune myasthenia gravis in the absence of decay accelerating factor protection
... that DAF is critical in conferring protec- tion against the development of weakness in passively induced ...of DAF in protecting against the patho- genic component of MG that is ...
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DAF shielded baculovirus vectored vaccine enhances protection against malaria sporozoite challenge in mice
... displaying decay-accelerating factor (DAF) on the surface of the viral envelope, resulting in a higher transduction efficacy in the presence of complement in vitro ...no DAF-display ...
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Interaction of Decay-Accelerating Factor with Coxsackievirus B3
... the DAF molecule determined the placement of SCR1 closer to a fivefold axis and SCR4 closer to a threefold axis ...the DAF density, indicating that the structure of DAF bound to the surface of the ...
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The HeLa cell receptor for enterovirus 70 is decay-accelerating factor (CD55).
... complement, DAF has recently been shown to act as a cellular receptor for at least six echovirus serotypes (3, 51) and for coxsackieviruses B1, B3, and B5 (5, ...of DAF involved in binding these different ...
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