Damage-associated molecular patterns (DAMPs)
Bench to bedside review: Damage associated molecular patterns in the onset of ventilator induced lung injury
... termed damage-associated molecular patterns (DAMPs), are released upon tissue injury and modulate the infl ammatory ...response. DAMPs activate pattern recognition receptors, may ...
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Hyperfibrinolysis in severe isolated traumatic brain injury may occur without tissue hypoperfusion: a retrospective observational multicentre study
... and damage-associated molecular patterns (DAMPs), such as histones [24, 25] and mitochondrial DNA [26], are re- leased from damaged tissue into the systemic circulation and activate the ...
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Repair after acute lung injury: molecular mechanisms and therapeutic opportunities
... cell damage and triggers the physio- logical ...called DAMPs (damage-associated molecular patterns), lead to this ...tissue damage by dead cells and local infl ammatory ...
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Thromboelastography and mean platelet volume as prognostic markers in sepsis: An Observational study
... pathogen associated molecular patterns ...various damage associated molecular patterns (DAMPS) which are endogenous molecules released from damaged host cells like ...
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Definitions and pathophysiology of vasoplegic shock
... been associated with adverse outcomes [1–3]; however, further discussion is beyond the scope of this ...pathogen-associated molecular pat- terns (PAMPS) and damage-associated ...
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The receptor for advanced glycation end products in ventilator-induced lung injury
... by damage-associated molecular patterns (DAMPs), which are endogenous molecules re- leased during tissue injury ...[12]. DAMPs are present in the alveolar compartment dur- ing ...
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Radiation-induced inflammation and autoimmune diseases
... through damage associated molecular patterns (DAMPs) by pattern recognition re- ceptors ...of DAMPs, such as oxidized DNA, high-mobility group box 1 (HMGB1), and uric acid [36, ...
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PubMedCentral-PMC5632128.pdf
... of damage associated molecular patterns, or DAMPs, that initiate activation of the innate immune ...of DAMPs, and/or the absence of activation of innate immune cells should mean ...
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Novel oncolytic chimeric orthopoxvirus causes regression of pancreatic cancer xenografts and exhibits abscopal effect at a single low dose
... Besides direct cell lysis, OVs are known to elicit potent anti-tumoral immune responses, mainly through release of tumor-associated antigens and ICD-related damage- associated molecular ...
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Micronutrients and many important factors that affect the physiological functions of toll-like receptors
... smoke; DAMPs: Damage- associated molecular patterns; DCs: Dendritic cells; EMT: Epithelial- mesenchymal transition; GC: Glucocorticoids; HCV: Hepatitis C virus; HFD: High-fat diet; HIV: ...
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High mobility group box 1 (HMGB1) and anti HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus
... creatinine; DAMPS: damage associated molecular patterns; eGFR: estimated glomerular filtration rate; ELISA: enzyme linked immunosorbant assay; HC: healthy controls; HMGB1: High Mobility ...
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The role of inflammation and interleukin-1 in acute cerebrovascular disease
... numerous damage associated molecular patterns (DAMPs) that act on pattern recognition receptors on immune cells to initiate and shape the inflammatory ...response. DAMPs ...
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PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses
... smoke; DAMPs: Damage-associated molecular patterns; DRP1: Dynamin- related protein 1; ER: Endoplasmic reticulum; ETC: Electron transport chain; FIS1: Mitochondrial fission 1 protein; ...
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Toll like receptor 4 single nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas
... carcinomas (HNSCC) [4,5]. Thus, infection and inflam- mation critically impact the development of HNSCC [6]. The family of mammalian Toll-like receptors (TLR) consists of 11 members and is mainly expressed on innate ...
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Necroptosis: a new link between cell death and inflammation
... releasing damage associated molecular patterns (DAMPs), such as nuclear high mobility group box- 1 proteins, mitochondrial DNA, and IL-1 family ...
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A prospective pilot study using metabolomics discloses specific fatty acid, catecholamine and tryptophan metabolic pathways as possible predictors for a negative outcome after severe trauma
... so-called damage-associated molecular patterns ...(DAMPs). DAMPs are considered danger signals which, paradoxic- ally, lead to propagation of injuries to remote tissues, ...
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Role of the IL-33-ST2 axis in sepsis
... tissue damage (necrotic cell death, cell stress) and/or mechanical injury, IL-33 expression increases and it is released into the extracellular space ...sense damage and alert neighboring cells and tissues ...
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Anticancer immunochemotherapy using adjuvants with direct cytotoxic effects
... danger-associated molecular pat- terns (DAMPs), which like PAMPs act as endogenous immunoadjuvants to elicit anticancer immune responses ...nent DAMPs are the preapoptotic exposure of ...
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Neutrophil heterogeneity and its role in infectious complications after severe trauma
... tissue damage, the reaction of the immune system on this tissue damage, the extent of systemic inflammation, and the development of infec- tious ...regarding damage control surgery and resuscitation, ...
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Personalizing blood pressure management in septic shock
... The available evidence suggests that targeting an MAP of 65–70 mmHg in a patient with septic shock who does not have chronic hypertension is a reasonable first approximation. Whereas in a patient with chronic hyper- ...
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