damage response
The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF kappaB activation
... inflicts damage to cellular DNA. This activates DNA damage response (DDR) signaling including induction of expression of DNA repair factor ...
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Sak and its potential role in the DNA damage response.
... DNA damage response. Although inactive in the absence of DNA damage, this protein is classically believed to become activated by ATM in response to ionizing radiation (for review, see Bartek ...
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The Smc complexes in DNA damage response
... The structural maintenance of chromosomes (Smc) proteins regulate nearly all aspects of chromosome biology and are critical for genomic stability. In eukaryotes, six Smc proteins form three heterodimers–Smc1/3, Smc2/4, ...
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Activation of the DNA Damage Response Is a Conserved Function of HIV 1 and HIV 2 Vpr That Is Independent of SLX4 Recruitment
... DNA damage response by primate lentivi- ...DNA damage response is a conserved outcome of expression of Vpr orthologs from both HIV-1 and HIV-2 and that it is largely conserved among primate ...
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Scorpins in the DNA Damage Response
... DNA damage response (DDR) is an attractive target for anti-cancer treatments due to the increased genotoxic stress that malignant cells experience[1] ...the damage are limited to a handful of ...
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Development and validation of an assay for the characterization of the DNA damage response to damage caused by superfund chemicals
... Determination of intracellular mode of action regarding how chemicals induce toxicity plays an important role for establishing risk assessment. Although several methods exist to ascertain how toxic substances act ...
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Saccharomyces cerevisiae Dap1p, a Novel DNA Damage Response Protein Related to the Mammalian Membrane-Associated Progesterone Receptor
... The response to damage is crucial for cellular survival, and eukaryotic cells require a broad array of proteins for an intact damage ...[for damage response protein related to ...
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Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... programmed response triggered in normal cells experiencing various types of stimuli, including telomere erosion [1-3], DNA damage [4], induction of oncogenes [5] and oxidative stress ...in response ...
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Roles of Ubiquitination and SUMOylation in DNA Damage Response
... from damage sites to allow binding of NER factors such as XPG and XPF (van Cuijk et ...a damage repair nuclease ...to damage sites (Perez-Oliva et ...
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A Synthetic Circuit For Control Of The Bacterial Dna Damage Response Without Dna Damage
... which damage becomes irreversibly lethal correlated with the carbon-energy availability of the culture, suggesting that cell death was occurring as a result of an energy-dependent ...lipid damage secondary ...
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Role and Regulation of CIEBPa in Response to DNA Damage
... DNA damage response To determine whether GSK3β has a role in C/EBPα induction in response to DNA damage, we treated BALB/MK2 keratinocytes with the GSK3β specific pharmacological inhibitors, ...
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THE ROLE OF REPLICATION PROTEIN A LARGE SUBUNIT FAMILY IN PATHOGEN-INDUCED DNA DAMAGE IN ARABIDOPSIS THALIANA, Nancy Lynn Fernandes
... DNA damage responses and is essential to plant immune ...defense response (Yan et ...SA response, inducing DNA damage and DSBs, indicating a DNA damage response mediated defense ...
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checkpoint following DNA damage by doxorubicin during transient mitotic arrest
... DNA damage is critical for cell survival. The serious damage is not able to be repaired during checkpoint and finally induces cell death to prevent abnormal cell ...DNA damage in mitotic ...DNA ...
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p16 and ARF: activation of teenage proteins in old age
... in response to DNA damage (21, ...DNA damage as a major factor inducing senescence: (a) telomere shortening induces senes- cence by activation of the DNA-damage response (16); (b) ROS ...
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Phosphatases in the cellular response to DNA damage
... cellular response to DNA damage. The DNA damage response network is composed of a large number of proteins with different functions that detect and signal the presence of DNA damage in ...
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<p>Digital Immune-Related Gene Expression Signatures In High-Grade Serous Ovarian Carcinoma: Developing Prediction Models For Platinum Response</p>
... In conclusion, our results suggest that response to platinum-based therapy and DFS is associated with dis- tinct gene-expression patterns related to the immune sys- tem. While the exact underlying mechanisms are ...
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An Investigation of Damage Mechanisms in Mechanobiological Models of In Stent Restenosis
... The proliferation of synthetic VSMCs post stenting is simulated using the IDM and CDM as damage stimuli for the VSMC agents. ECs are not included in this scenario. Figure 7A and B present the results of the ...
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Nuclear Localization of p38 MAPK in Response to DNA Damage
... in response to DNA damage, but not in response to other stimuli, pro- motes nuclear accumulation, it is possible that this nuclear shuttle is also specifically induced or acti- vated by DNA ...
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Sensory response following knee joint damage in rabbits
... In clinical research, poorer outcomes have been re- ported in patients with more severe knee joint injuries. For example, higher magnitude quadriceps arthrogenic muscle inhibition has been reported in patients with more ...
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Damage Detection in Composite Plates Using Dynamic Response
... To obtain a comparable complete set this set is then adjoined to the measured set, that’s why the term "Dynamic Expansion". The partitioning of matrices are needed for dynamic expansion, but also the location of ...
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