Databases used to identify validated microRNA targets
A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases
... be used to further prioritize cell types and thereby ...instead used potential spatial interactions as a simple and binary proxy for molecular ...be used to prioritize cell ...
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Can the microRNA expression profile help to identify novel targets for zoledronic acid in breast cancer?
... MiRNAs versus pathway heat map showed that, among the 21 deregulated miRNAs, 6 miRNAs shared 60 genes Figure 2: ZOL induces the expression of 11 specific miRNAs. (A) Validation of miRNA array data by quantitative ...
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MicroRNA Targets - How to predict?
... to identify the targets of all these small RNAs. Since, each microRNA can target several mRNA sequences, this will be a daunting task and will require the aid of in-silico target finder ...be ...
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Systems Biology Approach to Identify Transcriptome Reprogramming and Candidate MicroRNA Targets during the Progression of Polycystic Kidney Disease
... be used as prognostic markers of disease progression in ...miRNA targets and miRs-10a, -30a-5p, -96, -126-5p, -182, -200a, -204, -429, and -488 may be important players in cellular signalling events leading ...
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A Novel Method to Detect Functional MicroRNA Targets
... to identify possible miRNA targets have been ...six targets for two Drosophila melanogaster ...mammalian targets; experimentally, 11 out of 15 tested were ...predicted targets ...
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Computational identification of Penaeus monodon microRNA genes and their targets
... keyword to select only experimentally validated animal miRNAs. Finally the redundant miRNA sequences were removed. The remaining miRNAs were used as the reference set. The ESTs were obtained from the ...
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Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects
... well- validated targets will be supported by both genetic and chem- ical ...supported targets doubles the success rate in later stages of clinical development, 10 highlighting the impor- tance of ...
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Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects
... be used to identify potential drug ...been used to assist target based and phenotypic based drug development in other parasitic protozoa and why Leishmania has lacked a similar approach so ...
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Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer
... same samples and used miRNA target prediction pro- grams to identify putative miRNA:mRNA functional interactions. We then selected three candidate miRNA (miR-125b, miR-182 and miR-183) and six of their ...
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HuMiTar: A sequence-based method for prediction of human microRNA targets
... filter targets by using a predefined and rela- tively small number of false targets, ...miR targets, 38 con- firmed negative sites, and up to 5000 of artificially generated negative sites ...
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‘MicroRNA Targets’, a new AthaMap web-tool for genome-wide identification of miRNA targets in Arabidopsis thaliana
... specific databases that identify cis -regulatory ...PlantPan identify cis -regulatory sequences in ...these databases, AthaMap, a database for transcription factor bindings sites for the whole ...
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Accurate transcriptome-wide prediction of microRNA targets and small interfering RNA off-targets with MIRZA-G
... putative targets of a miRNA in the order of the scores assigned to them by a given prediction method and then we traversed the list of targets from top to bottom, computing, at each target rank x, the ...
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TargetOrtho: A Phylogenetic Footprinting Tool to Identify Transcription Factor Targets
... of validated DNA sequences whose content determines the resulting log-‐likelihood score of a given motif match, and because the final cumulative site score for each motif match is constructed using this PWM ...
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Experimental procedures to identify and validate specific mRNA targets of miRNAs
... curated databases of experimentally supported miR- NA/mRNA interactions, manual sequence inspection of cataloged miRNA binding sites in specific target mRNAs, and review of the published literature as a reliable ...
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A rapid method to screen putative mRNA targets of any known microRNA
... Polymerase chain reactions mRNA-derived cDNA above was amplified in another two reaction systems as described in the section for hybrid- PCR and sequencing, except that the initial annealing tem- perature was increased ...
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The use of administrative health care databases to identify patients with rheumatoid arthritis
... care databases are repositories of clini- cal information, which may be used to evaluate the frequency of disease, utilization, and cost of health care resources in a ...have used a variety of ...
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Can health care databases be used to identify incident cases of osteonecrosis?
... these databases to study ON and other rare diseases? Not ...be used as the basis of well-designed case-control studies, which can yield valid results comparable to those of cohort studies ...not ...
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Can Health Care Databases Be Used to Identify Incident Cases of Osteonecrosis?
... research databases in which standard protocols are used to collect data, they are subject to ...to identify a causal relationship between an exposure and a disease rather than an association in which ...
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MicroRNA Targets in Drosophila
... the targets and the mechanism of target suppression are currently unknown because reliable experimental methods for comprehensively identifying the miRNA targets are yet to be ...miRNA targets is ...
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MicroRNA targets in Drosophila
... URL. MicroRNA targets in Drosophila The emerging combinatorics of miRNA target sites in the 3' untranslated regions of messenger RNAs are reminiscent of transcriptional reg- ulation in promoter regions of ...
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