db/+ mice
<p>Olmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice</p>
... in mice through the modulation of AT-1R/MAPK pathway, 16 in both of which the rodent models of type 1 diabetes were ...in db/db mice, a type 2 diabetic murine model, 20 have not yet been ...in ...
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Chronic stress aggravates glucose intolerance in leptin receptor-deficient (db/db) mice
... in db/db mice is not present in obese humans (Tartaglia et ...the db/db mouse has been used to study the leptin-dependent mechanism of obesity and T2D for over 40 ...in ...
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Crocin ameliorates hepatic steatosis through activation of AMPK signaling in db/db mice
... (db/db) mice and their lean littermates (wild type) were obtained from Mode Animal Research Center of Nanjing ...male mice were maintained at 22 ± 2 °C with 60 ± 5% relative humid- ity, and ...
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Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron specific LEPR B transgenes
... generated mice that carry a neuron-specific leptin receptor (LEPR) transgene whose expression is driven by the rat synapsin I promoter synapsin–LEPR B ...generated mice that are compound hemizygotes for the ...
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<p>Artemether Regulates Metaflammation to Improve Glycolipid Metabolism in db/db Mice</p>
... to the suggestion that inhibition of in fl ammatory responses may provide a means to treat T2DM. 31 Of particular relevance to these fi ndings, our current results from liver protein chip analysis reveal that ATM can ...
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Evidence against a role for NLRP3 driven islet inflammation in db/db mice
... and db/þ littermate control mice ...< db > /J) were purchased from Jackson laboratories (USA) at 4 weeks of age and left to acclimatize for 2 ...All mice were housed at the Alfred ...
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Original Article Increased SPARC expression in skeletal muscle and adipose tissue of db/db mice
... In the current study, we aimed to determine whether elevated SPARC expression was asso- ciated with insulin resistance and T2DM. Analysis of SPARC mRNA and protein expres- sion levels clearly disclosed increased expres- ...
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Oral Quercetin Supplementation Lowers Plasma sICAM 1 Concentrations in Female db/db Mice
... healthy mice [30] and in strepto- zotocin-induced diabetic rats [31,32] revealed no impact of quercetin on body weight ...the db/db mouse as a model of diabetes because it reliably reflects the ...
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Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists A novel treatment strategy
... Treatment of db/db mice with A717 significantly reduced the proteinuria (1.52 +/- 0.3 mg/mg creatinine), inhibited mesangial matrix expansion, and attenuated overexpression of matrix mRNAs. The ...
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Metabonomic profiles delineate potential role of glutamate-glutamine cycle in db/db mice with diabetes-associated cognitive decline
... in db/db mice with DACD ...of db/db mice with DACD was significantly increased ...in db/db mice with ...in db/db mice with DACD ...
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Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice
... Abstract: Berberine (BBR) shows very low plasma levels after oral administration due to its poor absorption by the gastrointestinal tract. We have previously demonstrated that BBR showed increased gastrointestinal ...
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Glycemic improvement in diabetic db/db mice by overexpression of the human insulin regulatable glucose transporter (GLUT4)
... hGLUT4 db/db mice showed elevated plasma membrane-associated GLUT4 protein in the basal state, which markedly increased after an insulin/glucose ...nontransgenic db/db mice had ...
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The loss of GLUT2 expression by glucose unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment
... diabetic mice were, however, mostly unaltered. Transplanting islets from db/db mice under the kidney capsule of db/+ mice restored normal GLUT2 ...of db/+ islets into ...
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Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice
... in mice receiving any of the two ...the db/db mouse. In this strain of diabetic mice, EGCG and rosiglitazone treat- ment was associated with increases in insulin content and with preservation ...
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Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice
... male db/db and C57Bl/6 mice which were obtained from Harlan (Horst, the Netherlands) at an age of 5 ...supplier, db/db mice (n = 20) received standard chow and water ad libi- tum ...
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Comparison of Rosiglitazone and Metformin in Genetically Obese and Diabetic db/db Mice and Streptozotocin-Induced Diabetic Rat Models.
... in db/db mice and STZ-induced rat ...diabetic db/db mice were orally administered with either rosiglitazone (5 mg/kg/day) or metformin (150 mg/kg/day) for 10 ...in ...
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Glucose transporter levels in spontaneously obese (db/db) insulin resistant mice
... obese mice (C57BL/KsJ, db/db) and their lean littermates ...(db/db) mice were studied at 5 wk of age, when they were rapidly gaining weight and were severely insulin resistant, ...
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Evidence against a role for NLRP3 driven islet inflammation in db/db mice
... and db/þ littermate control mice ...< db > /J) were purchased from Jackson laboratories (USA) at 4 weeks of age and left to acclimatize for 2 ...All mice were housed at the Alfred ...
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Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
... Taken together our results suggest that curcumin improves the rate of oxygen consumption as well as ATPase activity probably by scavenging free radicals and preventing protein and lipid oxidation. Given that cen- tral ...
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Effect of echinacoside on kidney fibrosis by inhibition of TGF-β1/Smads signaling pathway in the db/db mice model of diabetic nephropathy
... in db/db mice, E-cadherin and α -SMA protein expression were detected by immunohistochemistry and Western blot (Figure 5A–C, F, and ...the db/m group, E-cadherin was significantly reduced in ...
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