DDB1/DDB2
DDB2 Induces Nuclear Accumulation of the Hepatitis B Virus X Protein Independently of Binding to DDB1
... wild-type DDB2 and the C-terminal deletion mutants of DDB2 except for the WD deletion mutant ...of DDB2 is essential for HBx ...mutant DDB2 proteins and DDB1, the mutants were ...
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Turnover of Hepatitis B Virus X Protein Is Regulated by Damaged DNA-Binding Complex
... the DDB1 subunit of the damaged DNA-binding (DDB) ...of DDB1 on the X protein is ...presence DDB2, the second subunit of the DDB ...HBx, DDB2 was found to directly bind to ...of DDB2 on ...
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Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy
... proteins, DDB2 and CSA, determines NER pathway activation after UV irradiation ...of DDB2 to trigger global genome repair ...(CUL4A- DDB1-DDB2-ROC1) is activated by dissociation from CSN and ...
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Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage
... with DDB1 [[33] and references therein]. Moreover, the DDB2-DDB1 complex can also recruit Cul4 to the damaged-DNA ...of DDB2 has been implicated in its nucleotide excision repair (NER) ...that ...
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Cell cycle and cell growth regulation by the CUL4-DDB1-ROC1 ubiquitin ligases
... Since the first substrate CDT1 was identified, CUL4-DDB1 has been shown to ubiquitinate multiple substrates. Paramyxovirus V proteins have been reported to hijack CUL4-DDB1 to ubiquitinate and degrade ...
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The p127 Subunit (DDB1) of the UV-DNA Damage Repair Binding Protein Is Essential for the Targeted Degradation of STAT1 by the V Protein of the Paramyxovirus Simian Virus 5
... 127-kDa DDB1 and a smaller 48-kDa subunit termed DDB2, which functions to activate DDB1 binding to damaged ...DNA. DDB1 is significantly more abundant than DDB2 (19, 41, 42) and ...
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Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways
... [27,28]. DDB1 is a large multi- domain protein that contains three β-propeller ...as DDB1 inter- actors that are presumed or known to function in sub- strate binding: hDET/hCOP1; CDT2/L2DTL/DTL; ...
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DDB1 and Cul4A Are Required for Human Immunodeficiency Virus Type 1 Vpr-Induced G2 Arrest
... following DDB1 or control siRNA ...of DDB1 siRNA ...of DDB1 siRNA ...of DDB2 siRNA shutdown in the absence of Vpr ...either DDB2 or control siRNA for 3 days, followed by the addition of ...
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Groh_unc_0153D_14160.pdf
... and DDB1 is predicted to include a short N-terminal α-helical motif termed the H-box (Li et ...of DDB1 interaction (Figure ...protein DDB2 makes a large contribution to DDB1 binding (Jin et ...
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Genetic analysis of Vprbp in mice
... with DDB1. However, a co- crystal structure of human DDB1 and zebrafish DDB2 unexpectedly revealed that the corresponding Arg residue in zebrafish DDB2 (Arg309) did not contact DDB1 ...
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Epstein-Barr Virus Latent Membrane Protein 1 Represses DNA Repair through the PI3K/Akt/FOXO3a Pathway in Human Epithelial Cells
... XPC, DDB2, and ...of DDB1 through the PI3K/Akt/FOXO3a pathway, leading to impaired DNA repair ...CUL4A- DDB1 ligase and subsequently affect the stability of its sub- strates, leading to perturbation ...
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Drosophila Damaged DNA-Binding Protein 1 Is an Essential Factor for Development
... The damaged DNA-binding protein (DDB) complex, thought to recognize (6-4) photoproducts and other lesions in DNA, has been implicated to have a role in global genomic nucleotide excision repair (NER) and E2F-1-mediated ...
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Hepatitis B Virus X Protein and Simian Virus 5 V Protein Exhibit Similar UV-DDB1 Binding Properties To Mediate Distinct Activities
... The DDB1 subunit of UV-DDB is a cellular target for the X protein of hepatitis B virus ...to DDB1 is a conserved feature among the mam- malian X proteins (41), and evidence has been presented that this ...
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Damaged DNA-binding protein 2 (DDB2) protects against UV irradiation in human cells and Drosophila
... subunits DDB1 (127 kDa) and DDB2 (48 kDa) [12,13]. The human DDB2 cDNA has been characterized [14] and the DDB2 protein has been demonstrated to rely on DDB1 to recognize UV-damaged DNA ...
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Distinct role of interleukin-6 and tumor necrosis factor receptor-1 in oval cell- mediated liver regeneration and inflammation- associated hepatocarcinogenesis
... injection. In addition, expression of HGF and TWEAK, two important mitogens for oval cells, was attenuated by IL6 depletion. HGF and TWEAK are secreted by stellate cells and macrophages respectively, their contribution ...
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Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr mediated G2 arrest
... the DDB1 and Cul4-associated factor 1 (DCAF1) and Rbx1 ...with DDB1 and Rbx1, respectively. The adaptor DDB1 links Cul4A to a variety of substrate specificity subunits, ...with DDB1 and Vpr ...
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Hunting for carotenoid derived retrograde signals that regulate plastid development
... DET1 encodes a nuclear protein acting downstream from the phytochrome photoreceptors to regulate light driven seedling morphogenesis and PhANG expression (Schroeder et al., 2002). It has been suggested that det1 ...
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Hepatitis B Virus X Protein Stimulates Viral Genome Replication via a DDB1-Dependent Pathway Distinct from That Leading to Cell Death
... to DDB1 is required for HBx stimulation of HBV ...lacks DDB1- binding and concomitant cytotoxic activities (21), affects nei- ther mutant nor wild-type HBV replication ...with DDB1 is required for ...
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Viral Transport of DNA Damage That Mimics a Stalled Replication Fork
... ATR, BLM, and Rad9, but not on ATM or NBS1, proteins. (A) U2OS cells not induced or doxycycline induced to express kinase-dead ATR and ATM-deficient and ATM-complemented human fibroblast cells (AT221JE-T) were infected ...
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In silico characterization of a novel pathogenic deletion mutation identified in XPA gene in a Pakistani family with severe xeroderma pigmentosum
... proteins DDB2 plays a key role in DNA repair by mak- ing physical interaction with residues 185–226 in XPA and initiate DDB-mediated NER reaction (Figure ...and DDB2 and, resulted in inability of cells to ...
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