Death Receptor Apoptotic Pathway
Houttuynia cordata Thunb extract modulates G0/G1 arrest and Fas/CD95-mediated death receptor apoptotic cell death in human lung cancer A549 cells
... The death receptor apoptotic pathway has previously been proposed as an anti-cancer drug target in human lung cancer ...the death receptor apoptotic pathway should ...
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To die or to differentiate: apoptotic and non apoptotic roles of death molecules in Drosophila melanogaster
... the receptor mediated death pathway that allows the animal to quickly respond to rapid environmental changes more ...distinct pathway, i.e., innate immune response pathway, which will ...
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Dodecanoic acid induces oxidative stress-mediated apoptotic death in liver cancer cells through mitochondrial pathway
... 25. Sheela DL, Narayanankutty A, Nazeem PA, Raghavamenon AC, Muthangaparambil SR. Lauric acid induce cell death in colon cancer cells mediated by the epidermal growth factor receptor downregulation: An in ...
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The Apoptosis Induction of Oleandrin on Osteosarcoma Cells through Regulating Mitochondrial- and Death Receptor-Dependent Apoptotic Pathways in Vitro
... † These authors contributed equally to this work. * Correspondence: [email protected]; Tel: +86-010-82267368 Abstract: Our previous study has found the anti-tumor activity of oleandrin in osteosarcoma cells in vitro, ...
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The Mediating Role of A2A Adenosine Receptors in the Mitochondrial Pathway of Apoptotic Hippocampal Cell Death, Following the Administration of MDMA in Rat
... Despite the persistent effects of MDMA on 5-HT axon terminals, there is evidence that MDMA produces neuronal degeneration within the hippocampus (Kermanian, et al., 2012; Warren, et al., 2007). The mechanism of MDMA- ...
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Sindbis Virus-Induced Neuronal Death Is both Necrotic and Apoptotic and Is Ameliorated byN-Methyl-d-Aspartate Receptor Antagonists
... both apoptotic and necrotic cell death occurred in infected neurons and that by- stander death occurred in uninfected ...neuronal death in these cultures. NMDA receptor antagonists ...
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Cx32 exerts anti-apoptotic and pro-tumor effects via the epidermal growth factor receptor pathway in hepatocellular carcinoma
... Although the diagnostic criteria and clinical therapeutic strategies have evolved in recent decades, hepatocellular carcinoma (HCC) remains the second most common cause of cancer-related death worldwide [11, 12]. ...
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Caspase Activation by Adenovirus E4orf4 Protein Is Cell Line Specific and Is Mediated by the Death Receptor Pathway
... Activation of caspase-9 is not part of the E4orf4 apoptotic pathway. Release of cytochrome c from the mitochondria is required for activation of caspase-9. To test whether caspase-9 is activated upon E4orf4 ...
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Death Receptor-Mediated Apoptotic Signaling Is Activated in the Brain following Infection with West Nile Virus in the Absence of a Peripheral Immune Response
... WNV-induced apoptotic neuronal death within the CNS have not been ...identified death receptor (DR)-induced apoptosis as a pathway that may be important in WNV pathogenesis, based on ...
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Androgen deprivation therapy sensitizes prostate cancer cells to T-cell killing through androgen receptor dependent modulation of the apoptotic pathway
... ABSTRACT Despite recent advances in diagnosis and management, prostrate cancer remains the second most common cause of death from cancer in American men, after lung cancer. Failure of chemotherapies and ...
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Unraveling the glucocorticoid receptor pathway in zebrafish
... dexamethasone. In general, the first cluster of genes contains mainly genes involved in metabolism, whereas the second cluster of genes mainly involves cell-cycle-related genes. For exa*);:(( +& under no exogenous ...
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Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway
... effects, apoptotic pathway Introduction Apoptosis is a normal physiological process that plays an important role in various phases of life, for example, in embryonic ...of apoptotic pathways and ...
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Myocardial ablation of G protein coupled receptor kinase 2 (GRK2) decreases ischemia/reperfusion injury through an anti-intrinsic apoptotic pathway
... Studies from our lab have shown that decreasing myocardial G protein–coupled receptor kinase 2 (GRK2) activity and expression can prevent heart failure progression after myocardial infarction. Since GRK2 appears ...
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Emodin induces apoptosis of human cervical cancer hela cells via intrinsic mitochondrial and extrinsic death receptor pathway
... Methods: Relative cell viability was assessed by MTT assay after treatment with emodin. Cell apoptosis was detected with TUNEL, Hoechst 33342 staining and quantified with flow cytometry using annexin FITC-PI staining. ...
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The Apoptotic Effect of the Methanol Extract of Polygonum cuspidatum through Up Regulation Death Receptor 5 and CHOP in HSC 2 Human Oral Cancer Cells
... To further investigate that whether MEPC-induced apo- ptosis is involved in extrinsic pathway by death receptors, the protein levels of death receptor 4 and 5 were detected. As shown in Figure ...
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Receptor-stimulated death pathway is opened by antigen in mature
... In this report we present evidence to support the hypothesis that the activation and the maturation state of the T cell may be important in coupling the TCR to the "death program.[r] ...
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Chandipura Virus Induces Neuronal Death through Fas-Mediated Extrinsic Apoptotic Pathway
... CHPV has a relatively short life cycle within the host, and our plaque assay data (see Fig. S2B in the supplemental material) con- firm that CHPV causes a productive viral infection resulting in widespread ...
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Both the apoptotic suicide pathway and phagocytosis are required for a programmed cell death in Caenorhabditis elegans
... cell death. In this way, we confirmed that B.al/rapaav cell death is dependent on both the suicide and engulfment path- ...cell death rather than temporarily delaying ...B.al/rapaav death is ...
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Neonatal Hypoxic-Ischemic Brain Injury: Apoptotic and Non-Apoptotic Cell Death
... proteins are required for initiation, vesicle elongation, autophagosome maturation, lysosome fusion, and degradation. Targeting the autophagic machinery could have significant impact in protecting the neonatal brain from ...
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Inflammatory but not apoptotic death of granulocytes citrullinates fibrinogen
... cell death would also have evolved mechanisms to limit modifications of neighboring pro- ...cell death continue to function in the extra- cellular ...
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