Defects in the insulin action: 67-69
Characterization of cellular defects of insulin action in type 2 (non insulin dependent) diabetes mellitus
... When the data are expressed as a percentage of the rate of total insulin-mediated glucose disposal (Tables IV and VI), it is apparent that in NIDDM patients the percentage of total gluco[r] ...
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Defects in insulin secretion and insulin action in non insulin dependent diabetes mellitus are inherited Metabolic studies on offspring of diabetic probands
... impaired insulin action in the offspring of probands with insulin resistant ...in insulin action alone can lead to NIDDM can not be solved by this ...with insulin resistant ...
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Human primary myoblast cell cultures from non diabetic insulin resistant subjects retain defects in insulin action
... lin action in ...by insulin-resistant cell cultures, cultures were grown for 7 d in six-well plates and any cultures not at 80–90% confluence were ...express insulin action in vitro with ...
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Insulin Secretory and Insulin Resistance Defects in Type 2 Diabetes Mellitus
... the insulin receptor; tyrosine phosphorylation of insulin receptor substrates activates phosphoinositide3 kinase (PI3K), with downstream effects to promote glycolysis, glycogen storage, protein ...
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Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery
... of insulin delivery on the regulation of hepatic glucose metabolism under postprandial glucose storage ...Peripheral insulin administra- tion alters the liver-to–arterial insulin gradient, but this ...
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Signaling pathways in insulin action: molecular targets of insulin resistance
... the insulin receptor kinase itself, as well as a reduction in IRS protein tyrosine phosphory- lation and PI 3-kinase association/activation in patients with type 2 ...in insulin receptor function represent ...
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Bidirectional modulation of insulin action by amino acids
... is insulin resistance in skeletal muscle, adipose tissue, and ...of insulin action in insulin-resistant animals and humans have demonstrated a va- riety of defects in insulin ...
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Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non insulin dependent diabetes mellitus
... and insulin secretion (oral glucose tolerance test and hyperglycemic [12 mM] clamp, including glucagon ...were insulin resistant and had a delayed insulin and C-peptide response during oral glucose ...
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REVIEW Exercise training-induced improvements in insulin action
... with insulin resistance are characterized by impaired insulin action on whole-body glucose uptake, in part due to impaired insulin-stim- ulated glucose uptake into skeletal ...an ...
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Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action
... of defects in insulin secretion and insulin action, thus recapitulating abnormalities observed in type 2 ...peripheral insulin action and ...of insulin resistance and type ...
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Treating dual defects in diabetes: Insulin resistance and insulin secretion
... of insulin sensitizers is particularly important because they address the problems of metabolic insulin resistance and reduce insulin ...basal insulin plus a secretague, the rapid-acting ...
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The insulin receptor and the molecular mechanism of insulin action
... Tyrosine kinase activity ofthe insulin receptor of patients with Type A extreme insulin resistance: studies with circulating mononuclear cells and cultured lymphocytes. Decreased insulin[r] ...
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Mechanism of Action of Indomethacin in Tubular Defects
... The finding of an increased rate of excretion of urinary prostaglandins, mainly PGE2, in patients with several tubular defects has led some investi- gators to ascribe to prostaglandins a[r] ...
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Multiple lipolysis defects in the insulin resistance (metabolic) syndrome
... the insulin resistance (or metabolic) syndrome and the abnormalities in free fatty acid metabolism associated with this disorder, the regulation of lipolysis in isolated subcutaneous adipocytes was investigated in ...
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Effects of Autoantibodies to the Insulin Receptor on Isolated Adipocytes: STUDIES OF INSULIN BINDING AND INSULIN ACTION
... the insulin receptor have been detected in the sera of several patients with the Type B syndrome of insulin resistance and acanthosis ...the insulin receptor in isolated rat ...the ...
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Insulin onset, peak and duration of action
... Basal insulin Basal insulin Basal insulin Basal insulin ---- twice a day might be needed … twice a day might be needed … twice a day might be needed … twice a day might be needed … A single ...
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Insulin transport across capillaries is rate limiting for insulin action in dogs
... eady-state were much less than plasma insulin during this period (P > 0.3). The concentration difference be- na insulin increased to 51±2 AU/ml but lymph tween plasma and lymph insuli[r] ...
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Insulin Binding to Monocytes and Insulin Action in Human Obesity, Starvation, and Refeeding
... and insulin action in vivo was examined in 14 obese subjects during the postabsorptive state and after starvation and ...to insulin was evaluated with the euglycemic insulin clamp ...plasma ...
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Insulin secretory defects in polycystic ovary syndrome Relationship to insulin sensitivity and family history of non insulin dependent diabetes mellitus
... function was evaluated during a frequently sampled intravenous glucose tolerance test, by a low dose graded glucose infusion, and by the ability of the beta cell to be entrained by an oscillatory glucose infusion. PCOS ...
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Mechanisms of Insulin Action and Na+/H+ Exchanger
... These results indicate that EIPA inhibited phos- phorylation of the insulin receptor as well as inhibited the Na+/H+ exchanger and that 3H-2-DG uptake in adipocytes[r] ...
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