Demethylase activity
UTX demethylase activity is required for satellite cell–mediated muscle regeneration
... H3K27 demethylase activity, suggesting an enzyme-independent role for UTX in development and thereby challenging the need for active H3K27 demethylation in ...H3K27 demethylase activity, as ...
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Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster
... histone demethylase activity of JMJD2A-C was assessed using the fluorogenic JMJD assay kit (BPS Bio- science, San Diego, CA) according to the manufacturer’s ...substrate, demethylase enzyme and ...
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Histone Demethylase Activity of Utx Is Essential for Viability and Regulation of HOX Gene Expression in Drosophila
... Figure 1 Utx demethylase activity is critical for viability and HOX gene reg- ulation. (A) Top: view of the genomic region harboring Utx and fl anking genes with coding (orange boxes) and noncoding exons ...
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In vitro effect of mitragynine on activity of drug metabolizing enzymes, n-demethylase and glutathione s-transferase in streptozotocin-induced diabetic rats
... CYP3A4 activity is twice in women than ...more activity in female than ...high activity in ...cytochrome activity in diabetic male and female rat hepatocytes and may be due to increase ...
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The Histone Demethylase KDM5 Is Essential for Larval Growth in Drosophila
... the demethylase activity of KDM5 primarily results in transcriptional ...enzymatic activity to disease ini- tiation and progression remains ...vitro demethylase activity, this is not ...
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Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis
... catalytic activity of PHF8 is required for HR repair, forced expression of PHF8/H247A could not restore BLM accumulation as PHF8/WT did, in PHF8-depleted cells (Figure ...the demethylase activity is ...
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Biochemical Characterization of Detoxifying Enzymes in Dimethoate Resistant Strains of Melon Aphid, Aphis gossypii(Hemiptera: Aphididae)
... esterase activity conferred resistance to malathion (OP) in Tetranychus kanzawai [54] and ...CarE activity and 11-fold elevated ac- tivity towards α -NA and β -NA, 12-fold for α -NB and 10-fold for α -NPr ...
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Histone Demethylase JMJD2A Regulates Kaposi's Sarcoma-Associated Herpesvirus Replication and Is Targeted by a Viral Transcriptional Factor
... Among the KSHV-encoded viral proteins studied, K-bZIP was found to be an interacting partner of JMJD2A. The inter- action can be detected at the endogenous level and confirmed by colocalization studies. Significantly, ...
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H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis
... The regulation of JMJD3 but not UTX expression dur- ing chondrogenesis suggests that JMJD3 plays the major role, and individually targeting each enzyme using siRNA showed that both regulated chondrogenic gene expression, ...
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EFFECT OF ORTHOSIPHO STAMIEUS AD TIOSPORA CRISPA O AMIOPYRIE METABOLISM I RATS
... enzyme activity of aminopyrine -demethylase using freshly isolated perfused ...N-demethylase activity was observed in the normal old female SD rats treated with 500 mg/kg ...
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Genome-wide identification and expression analysis of DNA demethylase family in cotton
... There are two possibilities for the deletion of methyl- ated cytosine, one caused by improper manipulation during DNA replication and the other by DNA demethylase activity. DNA demethylase contains a ...
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Original Article Epigenetic modulation by lysine-specific demethylase 1 induces gastric cancer metastasis
... Since it has been characterized by other sch- olars that LSD1 is required for Snail-mediated EMT and transcriptional repression of E-cad- herin in mesenchymal cancer cells [22-24], we speculated that LSD1 could promote ...
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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting
... histone demethylase, lysine-specific demethylase 1 (LSD1) in 2004 [43], challenged this notion and proved lysine methylation is dynamically ...LSD1 activity is highly context ...
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Original Article Upregulation of PSMD10 caused by the JMJD2A histone demethylase
... histone demethylase JMJD2A/ KDM4A and its interaction partner, the ETV1 transcription factor, in LNCaP prostate cancer ...histone demethylase by small molecule drugs may be effective to curtail the ...
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Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy
... Abstract: Acute myeloid leukemia (AML) is a clonal disorder of myeloid progenitors characterized by the acquisition of chromosomal abnormalities, somatic mutations, and epigenetic changes that determine a consistent ...
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Histone recognition and nuclear receptor co activator functions of Drosophila Cara Mitad, a homolog of the N terminal portion of mammalian MLL2 and MLL3
... Proteins that co-purify with the MLL2 include ASH2, RBBP5 (RBQ3), DPY30, WDR5, adaptor protein ASC2, PTIP, PA1 and histone demethylase UTX (Cho et al., 2007; Issaeva et al., 2007; Lee, S. et al., 2008; Mo et al., ...
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The histone demethylase PHF8 promotes prostate cancer cell growth by activating the oncomiR miR-125b
... To investigate the potential role of the histone demethylase PHF8 in human PCa, we first profiled the expression pat- tern of PHF8 in human normal prostate tissues and cancer tissues. We analyzed 19 normal tissues ...
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Identification and characterization of trimethylamine N oxide (TMAO) demethylase and TMAO permease in Methylocella silvestris BL2
... This is the peer reviewed version of the following article Zhu, Yijun , Jameson, Eleanor, Parslow, Rosemary A., Lidbury, Ian, Fu, Tiantian, Dafforn, Timothy R., Schäfer, Hendrik and Chen, Yin. (2014) Identification and ...
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H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming
... Previous studies have promoted mouse cloning efficiency by overexpression H3K9 demethylase (Matoba et al., 2014; Liu et al., 2016). Here, we validated this approach in cloned cattle production and showed an ∼ 15% ...
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Alterations in the predicted regulatory and coding regions of the sterol 14alpha-demethylase gene (CYP51) confer decreased azole sensitivity in the oilseed rape pathogen Pyrenopeziza brassicae
... CYP51, which results in decreased binding affinity for azoles, and also reduces enzyme activity (Kelly et al., 1999). The failure of PbCYP51 with G460S to complement yeast CYP51 suggests similar alterations in ...
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