Deubiquitinating enzyme
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
... identified deubiquitinating enzyme CYLD in osteoclastogenesis and found that mice with a genetic deficiency of CYLD had aberrant osteoclast differentiation and developed severe ...
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In Vivo Structure/Function Analysis of the Drosophila fat facets Deubiquitinating Enzyme Gene
... a deubiquitinating enzyme required for patterning the developing compound ...complex. Deubiquitinating enzymes are a large group of proteins that cleave ubiquitin-protein ...of ...
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Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor
... In this study we focused on Usp12, a deubiquitinating enzyme identified in an siRNA screen as a positive regulator of AR. Usp12 has three reported targets; histones H2B, H2A (23), and nonactivated Notch ...
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The Epstein-Barr Virus (EBV) Deubiquitinating Enzyme BPLF1 Reduces EBV Ribonucleotide Reductase Activity
... encoded deubiquitinating enzyme (DUB) is strictly conserved across the Herpes- ...exhibits deubiquitinating (DUB) activity that is lost upon mutation of the active-site ...EBV deubiquitinating ...
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The Rad6/18 Ubiquitin Complex Interacts with the Epstein-Barr Virus Deubiquitinating Enzyme, BPLF1, and Contributes to Virus Infectivity
... a deubiquitinating enzyme to target an E3 ligase, which could serve as a means of regulating the function of target proteins in a cell cycle-dependent fashion ...
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Ion mobility mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5
... Many proteins exhibit conformation flexibility as part of their biological function, whether through the presence of a series of well-defined states, or by the existence of intrinsic disorder. Ion mobility spectrometry, ...
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The deubiquitinating enzyme USP17 is associated with non- small cell lung cancer (NSCLC) recurrence and metastasis
... USP17 is a cell cycle regulated deubiquitinating enzyme that is highly expressed in tumor-derived cell lines and has an established role in cell proliferation and chemotaxis. This is the first study to ...
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The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein
... Background: Myeloid cell leukaemia 1 (MCL1) is a pro-survival Bcl-2 family protein that plays important roles in cell survival, proliferation, differentiation and tumourigenesis. MCL1 is a fast-turnover protein that is ...
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An OTU deubiquitinating enzyme in Eimeria tenella interacts with Eimeria tenella virus RDRP
... A linkage-specific deubiquitination assay was performed as follows: recombinant Et-OTU WT or 10 μM Et- OTU C239A , 10 μM Et-OTU D236A or 10 μM Et-OTU H351A was diluted to 5 μM in deubiquitinase (DUB) dilution buffer (25 ...
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Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway
... Our data confirms that Usp12 controls the levels of pAkt in PC cells by deubiquitinating and stabilising two Akt phosphatases PHLPP and PHLPPL. Depleting Usp12 results in increased pAkt and as such predisposes Akt ...
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The Papain-Like Protease from the Severe Acute Respiratory Syndrome Coronavirus Is a Deubiquitinating Enzyme
... the enzyme recognizes its sub- strate(s) are presently ...the enzyme is found within nsp3, the largest replicase subunit encoded by ...the enzyme in the free form exists in a conformation which is ...
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The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation
... When the tumors were separated into UCHL1 high and low expres- sion groups, tumors of the high UCHL1 group expressed significantly higher mRNA levels of differentiation markers such as G[r] ...
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The Translesion Polymerase Pol η Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1
... Expression of short hairpin RNA (shRNA) against BPLF1 and infection with an EBV knockout (KO) virus in which BPLF1 is not expressed result in decreased EBV genome copy numbers and infectivity (15). Similar findings have ...
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The deubiquitinating enzyme USP25 binds tankyrase and regulates trafficking of the facilitative glucose transporter GLUT4 in adipocytes
... Key to whole body glucose homeostasis is the ability of fat and muscle cells to sequester the facilitative glucose transporter GLUT4 in an intracellular compartment from where it can be mobilized in response to insulin. ...
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Targeting deubiquitinating enzyme USP26 by microRNA-203 regulates Snail1’s pro-metastatic functions in esophageal cancer
... One of the most important and well-characterized transcription factors required for EMT progression is SNAI1, which encodes Snail1. Expression of Snail1 was found to be positively correlated to metastatic progres- sion ...
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The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility
... Deubiquitinating enzymes are now emerging as potential therapeutic targets that control many cellular processes, but few have been demonstrated to control cell motility. Here, we show that ubiquitin-specific ...
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The deubiquitinating enzyme UBPY is required for Lysosomal Biogenesis and productive autophagy in drosophila
... Deubiquitinating enzymes (DUBs) remove ubiquitin monomers or polymers from ubiquiti- nated proteins and thereby serve as key regulators of ubiquitin-dependent processes [13, 14]. A hundred DUBs have been ...
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Deubiquitinating enzyme USP37 regulating oncogenic function of 14-3-3
... 14-3-3 is a family of highly conserved protein that is involved in a number of cellular processes. In this study, we identified that the high expression of 14-3- 3γ in various cancer cell lines correlates with the ...
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Molecular Characterization and Analysis of the acrB Gene of Aspergillus nidulans: A Gene Identified by Genetic Interaction As a Component of the Regulatory Network That Includes the CreB Deubiquitination Enzyme
... Mutations in the acrB gene, which were originally selected through their resistance to acriflavine, also result in reduced growth on a range of sole carbon sources, including fructose, cellobiose, raffinose, and starch, ...
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Original Article USP7 promotes tumorigenesis in breast cancer and enhances MRI detection
... the deubiquitinating enzyme, USP7 is high expression in breast cancer and positive associate with lymph node metastasis and a poor ...through deubiquitinating Snail, thereby stabilize Snail, and ...
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