Diagnostic biomarkers
Circulating microRNAs as potential diagnostic biomarkers for osteoporosis
... Osteoporosis is the most common age-related bone disease worldwide and is usually clinically asymptomatic until the first fracture happens. MicroRNAs are critical molecular regulators in bone remodelling processes and ...
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Flexible combination of multiple diagnostic biomarkers to improve diagnostic accuracy
... multiple biomarkers in vari- ous fields, including genotype classification [15], medical diagnosis [16], and treatment selection ...the biomarkers are flexibly combined into one single diag- nostic score so ...
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Plasma Antibody Profiles as Diagnostic Biomarkers for Tuberculosis
... TB diagnostic methods are subjective, inefficient, or not ...sputum-based diagnostic methods (smear microscopy and culture) practiced in countries where TB is ...
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Prostasomes as a source of diagnostic biomarkers for prostate cancer
... Analysis of isolated prostasomes has additional advantages over the analysis of their originating PCa cells, which may also be isolated from blood or urine. First, EVs are extremely stable, and RNA within their lumen can ...
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Biofluid lipidome: a source for potential diagnostic biomarkers
... shotgun lipidomic workflow wherein all lipid precur- sor ions are fragmented without any prior selection thereby increasing the possibility of identifying multiple lipid species [79]. Elevated levels of triglycerides ...
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Identification of serum microRNAs as diagnostic biomarkers for schizophrenia
... ROC curves of the 3 miRNAs were constructed to fur- ther evaluate their diagnostic values. As shown in Fig. 2 and Table 3, miR-432a-5p has the best discriminatory performance with an AUC of 0.764 (95% CI: ...
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A multiplex immunoassay for the non invasive detection of bladder cancer
... derive diagnostic signa- tures that show promise for the accurate detection of BCa in voided urine samples ...14 biomarkers were significantly altered in BCa compared to controls ...10-biomarker ...
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Diagnostic significance of microRNAs as novel biomarkers for bladder cancer: a meta analysis of ten articles
... poor diagnostic performance with an AUC value of 0.74, while the diagnostic accuracy of multiple-miRNA assays is significantly higher with an AUC of ...curate biomarkers for ...the diagnostic ...
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Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers
... Besides from its specific protein, exosomes also carry a select set of functional circulating nucleic acids such as mRNAs, miRNAs, LncRNAs and DNA [81]. Exosomes are the main source of circulating miRNAs. So far, a great ...
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Review Article Diagnostic and Prognostic Biomarkers in Pancreatic Carcinoma
... sensitive diagnostic biomarkers as screening tools is crucial in detecting preinvasive pancreatic ...protein-based biomarkers have been extensively ...including biomarkers from blood, tissue ...
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Prognostic scores and biomarkers for pediatric community-acquired pneumonia: how far have we come?
... incorporate biomarkers in risk stratification because they are good predictors of disease severity and outcome, irrespective of age ...of biomarkers was initially more established in geriatric CAP, they ...
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TIMP 2/IGFBP7 predicts acute kidney injury in out of hospital cardiac arrest survivors
... All patients with myocardial ischaemia as the sus- pected cause of cardiac arrest were transferred to the catheter laboratory for coronary angiography and revas- cularization when indicated prior to admission to the ICU. ...
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Development and external validation of a faecal immunochemical test-based prediction model for colorectal cancer detection in symptomatic patients
... We also analysed the discriminatory ability of the COLONPREDICT score for AN and SCL detection in symptomatic patients. The AUC of the model was 0.83 (0.80–0.85) and 0.82 (0.80–0.84), respectively. The ana- lysis of the ...
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Clinical utility of diagnostic guidelines and putative biomarkers in lymphangioleiomyomatosis
... ERS diagnostic criteria amongst respiratory physicians could reduce the use of lung biopsy in suspected LAM and this could be improved further by incorporating VEGF-D measurement into the diagnostic ...
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The role of novel biomarkers in childhood idiopathic nephrotic syndrome: a narrative review of published evidence
... ideal diagnostic steps to identify these histo- logical subtypes, reports indicate that serum and urinary biomarkers are now being utilized in the investigation of childhood idiopathic nephrotic ...the ...
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Cell cycle regulatory markers in melanoma: New strategies in diagnosis and treatment
... The other overexpressed marker in melanoma is insulin- like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), which binds to its targeted RNA to regulate its expression. In the study of Pryor et al, IMP3, ...
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Drug-induced interstitial lung disease in the treatment of malignant lymphoma as a potential diagnostic marker: a comparison of serum Krebs von Lungen-6 and thymus and activation-regulated chemokine/CC chemokine ligand 17
... Purpose: Cure-oriented treatment of malignant lymphoma (ML) is possible even in an advanced stage; however, the progression of drug-induced interstitial lung disease (DILD) sometimes accounts for poor clinical outcomes. ...
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Extracellular nucleic acids and their potential as diagnostic, prognostic and predictive biomarkers
... cancer biomarkers should be accurately detectable in a readily accessible body fluid, such as serum, saliva or urine, permitting minimally-invasive procedures and ongoing/ sequential monitoring of the course of ...
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The DiPEP (Diagnosis of PE in Pregnancy) biomarker study: An observational cohort study augmented with additional cases to determine the diagnostic utility of biomarkers for suspected venous thromboembolism during pregnancy and puerperium
... that biomarkers will have the same sen- sitivity in PE and DVT and empirical studies of D-dimer have shown similar sensitivity in DVT and PE (Stein et al, ...
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A comparison of current serum biomarkers as diagnostic indicators of mitochondrial diseases
... analysis, as it was reported that a parametric correla- tion test (Pearson) was used for the severe group and then compared to a nonparametric correlation test (Spearman) for asymptomatic, mild and moderate severity ...
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