Differences in genome-wide association studies
GENOME-WIDE ASSOCIATION STUDIES IN PHARMACOGENOMICS
... inter-individual differences in drug response, but for certain drugs, this can even be higher ...individual differences of treatment efficacy and adverse ...
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On Considering Epistasis in genome Wide Association Studies.
... pilot genome-wide association study of Extrapulmonary Tuberculosis In the fifth chapter, I perform a GWAS analysis on the same population sample used in the candidate gene analysis of the previous ...
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Genome-wide Association Studies in Maize and Sorghum
... allelic differences impact the degree to which populations inter-mate, it will surely have an impact on allele frequencies in other areas of the genome and impact the amount of gene flow from one population ...
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Genetics of migraine in the age of genome-wide association studies
... with genome-wide significance and none of the implicated genes has been a candidate in previous genetic ...the association at rs10166942 (TRPM8) for the first time implicates a gene in a pain related ...
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Q&A: Promise and pitfalls of genome-wide association studies
... can genome-wide association studies (GWAS) make it possible to identify the predisposing genes in multifactorial diseases? This approach is driven by the new technologies that allow tens or ...
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Enrichment of statistical power for genome-wide association studies
... Spurious association can also be caused by differences in relatedness between pairs of individuals. This effect can be reduced using a general linear model (GLM) to estimate the proportion of genes ...
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Genome-wide association studies of childhood bone health
... Long-term goals are that 70% of the children undergoing the recommended interventions will show at least a 10 percentile increase in bone mineral density after participating in the program for 1 year. Further, 20% of the ...
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Genome-wide association studies of multiple keratinocyte cancers
... reach genome-wide significance (lowest p-value was ...to differences in the imputation quality thresholds between the Harvard cohorts and the RS and FHS, we may have missed GWAS ...
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Genome wide association studies on HIV susceptibility, pathogenesis and pharmacogenomics
... these studies, variants in the HLA-region and the coreceptor CCR5 were the most consistent and with the largest ef- fect ...observed differences in HIV-1 infection and dis- ease progression in the ...
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Commercially Available Outbred Mice for Genome-Wide Association Studies
... Abstract Genome-wide association studies using commercially available outbred mice can detect genes involved in phenotypes of biomedical ...to differences between colonies. However, ...
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Breast cancer genome-wide association studies: there is strength in numbers
... multistage studies and they require large amounts of ...some differences were found between different ...sample-size differences or genetic heterogeneity in the setting of different genotyping ...
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Genome-wide association studies with metabolomics
... Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nat Protoc 2011, 6:1060-1083. 38. Nicholson G, Rantalainen M, Li JV, ...
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Genome-Wide Association Studies of Asthma
... Large sample sizes are required to ensure suffi- cient statistical power, and collaborative studies on samples from a large number of cohorts have pro- vided new insights about the genetic bases of com- mon ...
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Genome wide association studies in neurology
... Correspondence to: Lan Tan. Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, China. Email: [email protected]; Jin-Tai Yu. Department ...
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Genome wide association studies in asthma
... 37.. approaches used to identify genetic loci associated with asthma diagnosis. See also.. DOI: 10.1002/9780470015902.a0021458 and DOI: 10.1002/9780470015902.a0021995.[r] ...
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Genome wide association studies: a primer
... Key ethical issues under current debate include the need for new approaches to informed consent for large-scale genetic studies and consideration of the legal issues relating to confidentiality and use of gen- etic ...
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Genome-Wide Association Studies in Glioma.
... After identification through fine-mapping rs55705857 represents the likely causal variant at the 8q24.21 glioma risk locus (28,34). Jenkins et al. (28) and Enciso-Mora et al. (34) suggest that the association ...
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Genome-wide association studies in asthma
... in cases and controls with very stringent statistical thresholds, e.g. See Figure 1 for an overview of 37.. approaches used to identify genetic loci associated with asthma diagnosis. See[r] ...
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Genome-Wide Association Studies of Allergic Diseases
... genetics, Genome-Wide Association Study, polymorphisms INTRODUCTION The genome is the set of all genes, regulatory se- quences and other information included in the non- coding ...Human ...
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Statistical Methods for Genome Wide Association Studies
... of the disease’. Reich and Lander [26] formulated the hypothesis as ’if the num- ber of loci contributing to disease risk is moderate, then a few disease alleles should account for a large proportion of the genetic ...
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