Dihydropyrimidine dehydrogenase
ASSOCIATION OF DIHYDROPYRIMIDINE DEHYDROGENASE GENE POLYMORPHISM WITH TOXICITY OF 5 FLUROURACIL IN COLORECTAL CANCER IN KHARTOUM STATE
... The activity of dihydropyrimidine dehydrogenase enzyme (DPD) varies widely, with most of the variability arising from genetic polymorphisms in the DPYD gene. Patients who are partially or totally deficient ...
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Clinical significance of the thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase mRNA expressions in hepatocellular carcinoma patients receiving 5-fluorouracil-based transarterial chemoembolization treatment
... Purpose: To determine whether 5-fluorouracil (5-FU) sensitivity is associated with the mRNA expressions of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and[r] ...
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Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas
... Because dihydropyrimidine dehydrogenase (DPD) was reported to be involved in 5-FU metabolism to block DNA damage, we compared the survival rate with 5-FU treatment and the level of DPD expression in 15 ...
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Severe toxicity to capecitabine due to a new variant at a donor splicing site in the dihydropyrimidine dehydrogenase <em>(DPYD)</em> gene
... for dihydropyrimidine dehydrogenase (DPYD) deficiency is encouraged before start of treatment, but the genetic variants that are commonly analyzed often fail to explain toxicities seen in clinical ...
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Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers
... The fluoropyrimidine anticancer drugs 5-fluorouracil (5-FU) and its oral prodrug capecitabine are commonly used in the treatment of solid tumours, including early and advanced breast, colorectal, gastric and head-and-neck ...
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Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5 fluorouracil toxicity
... Dihydropyrimidine dehydrogenase (DPD) deficiency con- stitutes an inborn error in pyrimidine metabolism associ- ated with thymine-uraciluria in pediatric patients and an increased risk of toxicity in cancer ...
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Familial deficiency of dihydropyrimidine dehydrogenase Biochemical basis for familial pyrimidinemia and severe 5 fluorouracil induced toxicity
... for dihydropyrimidine dehydrogenase in peripheral blood mononuclear cells, we demonstrated complete deficiency of enzyme activity in the patient and partial deficiency of enzyme activity in her father and ...
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High expression of intra-tumoral dihydropyrimidine dehydrogenase is a negative prognostic factor in patients treated with adjuvant 5-fluorouracil based chemotherapy following resection of pancreatic adenocarcinoma
... In conclusion, the present study demonstrates that high intra-tumoral expression of DPD is associated with reduced survival following postoperative 5-fluorouracil with folinic acid adjuv[r] ...
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Original Article Correlations between expression levels of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase, and efficacy of 5-fluorouracil-based chemotherapy for advanced colorectal cancer
... Abstract: The efficacy of 5-fluorouracil (5-FU)-based chemotherapy for colorectal cancer (CRC) widely varies among patients; therefore, it is difficult to accurately predict chemotherapeutic responses. Some recent ...
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Pyrimidine base degradation in cultured murine C 1300 neuroblastoma cells and in situ tumors
... Dihydropyrimidine dehydrogenase DPD, the initial, rate-limiting step in pyrimidine degradation, was studied in two cell lines of murine neuroblastoma MNB-T1 and MNB-T2 that were derived [r] ...
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Analysis of Pyrimidine Catabolism in Drosophila melanogaster Using Epistatic Interactions With Mutations of Pyrimidine Biosynthesis and β-Alanine Metabolism
... The biochemical pathway for pyrimidine catabolism links the pathways for pyrimidine biosynthesis and salvage with b-alanine metabolism, providing an array of epistatic interactions with which to analyze mu- tations of ...
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OPRT Is a Potential Predictive Factor for the Response to S 1 in Gastric Cancer
... phosphorylase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase using quantitative re- verse-transcriptase polymerase chain ...and dihydropyrimidine dehydrogenase ...
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Index Catalog // Carolina Digital Repository
... Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fl[r] ...
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MOLECULAR MARKERS FOR CAPECITABINE THERAPY: A REVIEW
... Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients tre[r] ...
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Synthesis and in-vitro screening of novel dihydropyrimidine derivatives as potential calcium channel blockers
... effects. Dihydropyrimidine derivatives are widely used for the variety of pharmacological actions [3,4] and are screened for diverse range of biological activities such as calcium channel blocker [5,6], ...
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Essentiality of Succinate Dehydrogenase in Mycobacterium smegmatis and Its Role in the Generation of the Membrane Potential Under Hypoxia
... Members of the genus Mycobacterium harbor two copies of the succinate dehydrogenase operon designated sdh1 and sdh2, but the reasons for this remain unclear. In this communication, we report that the sdh operons ...
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Biochemical and ultrastructural study of Blastocystis hominis
... Despite the presence of large numbers of mitochondria, activities of the mitochondrial enzymes pyruvate dehydrogenase complex, a-ketoglutarate dehydrogenase complex, isocitrate dehydroge[r] ...
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The Respiratory and Glycolytic Enzymes of Sea Urchin Eggs
... Activity corresponding to phosphoglucomutase, phosphohexoisomerase, aldolase, triosephosphate dehydrogenase, enolase and lactic dehydrogenase has been demonstrated in homogenates prepare[r] ...
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Michael hydratase alcohol dehydrogenase or just alcohol dehydrogenase?
... alcohol dehydrogenase (MhyADH) from Alicycliphilus denitrificans was previously identified as a bi-functional enzyme performing a hydration of α , β -unsaturated ketones and subsequent oxidation of the formed ...
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EFFECTS OF SUBSTRATES ON GENE-CONTROLLED ENZYME ACTIVITIES IN CULTURED EMBRYONIC CELLS OF DROSOPHILA
... Since the levels of xanthine dehydrogenase and alkaline phosphatase are not affected, since the increases and decreases in alcohol dehydrogenase are changes in specific activ[r] ...
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