Four dimensional analysis of kinetochore and spindle
The spindle checkpoint monitors kinetochore spindle microtubule
... mitotic spindle axis indicates that kinetochores are competent to bind ...single spindle pole, as well as the absence of separation of the marked sister centromeres, suggests monotelic kinetochore ...
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Kinetochore dynamics and their attachment to the mitotic spindle
... 1.4. Kinetochore dynamics 1.4 Kinetochore dynamics A powerful way to understand kinetochore structure in relation to force generation and attachment state, is to investigate their dynamic behaviour ...
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Electron cryotomography analysis of Dam1C/DASH at the kinetochore–spindle interface in situ
... the spindle pole body, but not those nearby, recruited checkpoint proteins (Gillett et ...the spindle remnant’s short kMTs have mostly complete ...and kinetochore conformation and composition merits ...
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Kinetochore generated pushing forces separate centrosomes during bipolar spindle assembly
... to spindle bipolarity by using poleward MT fl ux to push centrosomes ...This kinetochore-dependent spindle assembly pathway cooperates with aurora A, as inactivation of both poleward MT fl ux and ...
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The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle
... Sikirzhytski V, Magidson V, Steinman JB, He J, Le Berre M, Tikhonenko I, Ault JG, McEwen BF, Chen JK, Sui H, Piel M, Kapoor TM, Khodjakov A. 2014. Direct kinetochore-spindle pole connections are not ...
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The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond
... of kinetochore microtubules [52] but tension between sister-kinetochores was reduced, provid- ing the strongest evidence so far for presence of a 'tension- only'-checkpoint in mammalian ...the spindle ...
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The Spindle Checkpoint of the Yeast Saccharomyces cerevisiae Requires Kinetochore Function and Maps to the CBF3 Domain
... that kinetochore does not assure that 100% of the protein is ...every kinetochore is affected in a tion cannot ...the kinetochore indirectly affects the kinetochores are affected in the cse4 ...the ...
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Saccharomyces cerevisiae BUB2 Prevents Mitotic Exit in Response to Both Spindle and Kinetochore Damage
... The spindle assembly checkpoint-mediated mitotic arrest depends on proteins that signal the presence of one or more unattached kinetochores and prevents the onset of anaphase in the presence of kinetochore ...
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APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment
... the Spindle Assembly Checkpoint (SAC) that monitors kinetochore attachment to the mitotic ...last kinetochore attaches to the spindle is important to understand how cells maintain genomic ...
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Tethering Sister Centromeres to Each Other Suggests the Spindle Checkpoint Detects Stretch within the Kinetochore
... the spindle checkpoint does not monitor the distance between sister ...the spindle checkpoint and thus that some of the cells in this strain would enter anaphase more slowly than the control strain ...
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Spindle and kinetochore associated complex subunit 1 regulates the proliferation of oral adenosquamous carcinoma CAL-27 cells in vitro
... mitotic spindle is a complex mechanical apparatus required for the accurate segregation of sister chromosomes during ...mitosis. Spindle and kinetochore associated complex subunit 1 (SKA1) is a ...
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Two Complexes of Spindle Checkpoint Proteins Containing Cdc20 and Mad2 Assemble during Mitosis Independently of the Kinetochore in Saccharomyces cerevisiae
... the kinetochore in the formation of MCC and Mad2-Cdc20 for three important ...the spindle checkpoint function in our ndc10-1 mutant strains ...is kinetochore dependent and it was not tested ...the ...
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Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.
... MAD1 kinetochore recruitment, this should prevent centrosomal accumulation following NDGA ...no kinetochore or centrosomal accumulation was evident ...MAD1 kinetochore localisation at unaligned ...
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Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.
... MAD1 kinetochore recruitment should prevent its centrosomal accumulation following NDGA ...no kinetochore or centrosomal MAD1 accumulation was evident ...MAD1 kinetochore localisation in ...
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Cell Cycle Arrest in cdc20 Mutants of Saccharomyces cerevisiae Is Independent of Ndc10p and Kinetochore Function but Requires a Subset of Spindle Checkpoint Genes
... The spindle checkpoint ensures accurate chromosome segregation by inhibiting anaphase onset in response to altered microtubule function and impaired kinetochore ...the kinetochore protein encoded by ...
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Thein, Kerstin (2008): Functional characterization of the mitotic-spindle and kinetochore associated protein astrin. Dissertation, LMU München: Fakultät für Biologie
... inactivation. Cells depleted of astrin exhibit premature separase activity but the APC/C is still inhibited, since securin and cyclin B1 are stable (Figure 36). By comparing the effects of astrin depletion with the ...
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Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins
... all four components of the NDC80 linker complex, three components of MIND and SPC105 (Figure 10b, Additional data file ...the spindle assembly checkpoint in yeast or human cells (Figure ...simple ...
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Molecular analysis of core kinetochore composition and assembly in Drosophila melanogaster
... NDC80 kinetochore complexes together with known kinetochore associated proteins such as dynein/dynactin, spindle assembly checkpoint components and heterochromatin ...eight kinetochore complex ...
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Four-dimensional Mathematical Data Visualization via Embodied Four-dimensional Space Display System
... Key words: 4-D mathematical data, 4-D Euclidean space, 4-D visualization, 4-D interaction 1. Introduction We draw diagrams of space information and measure- ment results within a 2-D plane or 3-D space. In primary ed- ...
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Bifurcations in four dimensional switched systems
... These phenomena and bifurcation theory are extremely important in understanding the qualitative change in the dynamical behavior that appears on the surface of discontinuity. In smooth systems these topics are especially ...
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