Disc degeneration
Biologic Treatment of Mild and Moderate Intervertebral Disc Degeneration
... Disc degeneration is the most common cause of back pain in adults and has enormous socioeconomic ...moderate disc degeneration, where a potential for regeneration still ...intervertebral ...
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The effects of human Wharton’s jelly cell transplantation on the intervertebral disc in a canine disc degeneration model
... IVD degeneration- related diseases before the ...induce disc degeneration, an 18-gauge needle was inserted at the center of the disc through the annulus fibrosus (AF) into the ...single ...
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Disc degeneration implies low back pain
... Disc degeneration is ...of disc degeneration and monitor them over time for disc-signal ...new disc degeneration over a 5-year ...average degeneration rate λ 1 ≅ ...
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Stem cell horizons in intervertebral disc degeneration
... Intervertebral disc degeneration remains a pervasive and intractable disease arising from a combination of aging and stress on the back and ...intervertebral disc, and the diffi culty of obtaining ...
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Landscape of RNAs in human lumbar disc degeneration
... Accumulating evidence indicates noncoding RNAs (ncRNAs) fine-tune gene expression with mysterious machinery. We conducted a combination of mRNA, miRNA, circRNA, LncRNA microarray analyses on 10 adults’ lumbar discs. ...
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Different spinal subtypes with varying characteristics of lumbar disc degeneration at specific level with age: a study based on an asymptomatic population
... However, several limitations still exist in our study. First, because of the nonuniform population distribution of the Chinese participants, the sample size for type IV spine is small. Second, the purpose of our study ...
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VEGF vascularization pathway in human intervertebral disc does not change during the disc degeneration process
... across disc degeneration grades showed that membrane and soluble forms of this receptor, together with other components of classic vascularization pathways, are constitutively expressed across human ...
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The role of interleukin 1 in the pathogenesis of human Intervertebral disc degeneration
... characterize disc degeneration, namely, decreased matrix synthesis and increased production of MMPs and ADAMTS-4 ...human disc cells cultured in 3D ...
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Transplantation of human Wharton’s jelly-derived mesenchymal stem cells highly expressing TGFβ receptors in a rabbit model of disc degeneration
... of disc degeneration, all rabbits were euthanized with carbon dioxide inhalation and the L1–L6 vertebral bodies from all rabbits were fixed in 4 % ...
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Short Link N promotes disc repair in a rabbit model of disc degeneration
... The degeneration of the intervertebral disc (IVD) is characterized by proteolytic degradation of the extracellular matrix, and its repair requires the production of an extracellular matrix with a high ...
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Correlation between intervertebral disc degeneration, paraspinal muscle atrophy, and lumbar facet joints degeneration in patients with lumbar disc herniation
... Several recent studies have investigated the biomech- anics and microstructures of the multifidus muscles in patients with LDH [5, 6]. An association between multi- fidus muscle degeneration and chronic low back ...
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Morphology of intervertebral disc ruptures evaluated by vacuum phenomenon using multi detector computed tomography: association with lumbar disc degeneration and canal stenosis
... This study describes the assessment of IVD ruptures by the presence of intradiscal VPs using CT-imaging. This two-part classification can comprehensively present the shape and axial distribution of VPs within IVDs, with ...
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Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration
... showing disc degeneration, but the morphology of these cells was no different from that of the cells normally found ...NP disc cells can indeed behave as phagocytes and undertake phagocytosis, at ...
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Histological analysis of surgical lumbar intervertebral disc tissue provides evidence for an association between disc degeneration and increased body mass index
... intervertebral disc prolapse has ...herniated disc material with clinical ...vertebral disc compartments in the process of disc degeneration and ...observed disc alterations, ...
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A Dose–response relationship between severity of disc degeneration and intervertebral disc height in the lumbosacral spine
... severe disc degeneration, thus limiting the generalizability of our ...grade-5 disc degeneration, which has a hallmark fea- ture of a collapsed disc space, could have been driving the ...
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Original Article A porcine model of lumbar disc degeneration induced by superficial layer of annular injury
... lumbar disc degeneration induced by superficial layer of annular injury that closely mimicked human disc ...adjacent disc was injured by a ...injury. Disc appearance was visualized by ...
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Minimal invasive annulotomy for induction of disc degeneration and implantation of poly (lactic-co-glycolic acid) (PLGA) plugs for annular repair in a rabbit model
... So far, annular injury is one of the most common surgi- cal modalities in various animal models of disc degenera- tion [4]. Previous studies have used several diffuse annular incisions, including a cruciate, ...
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Cervical disc degeneration and neck pain
... intervertebral disc has long been considered a common source of neck ...the disc itself has not been clearly defined so far, and its diagnosis and treatment has always been ...cervical disc has a ...
5
Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant
... Lumbar disc degeneration (LDD) is associated with both genetic and environmental factors and affects many people ...intervertebral disc cells of human subjects carrying the A allele of ...
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The role of interleukin 1 in the pathogenesis of human intervertebral disc degeneration
... characterize disc degeneration, namely, decreased matrix synthesis and increased production of MMPs and ADAMTS-4 ...human disc cells cultured in 3D ...
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