Discoidin domain
Spatial localisation of Discoidin Domain Receptor 2 (DDR2) signalling is dependent on its collagen binding and kinase activity.
... Discoidin Domain Receptor 2 (DDR2) is a collagen-binding receptor tyrosine kinase that initiates delayed and sustained tyrosine phosphorylation signalling. To understand the molecular basis of this unique ...
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Functional analysis of conserved aromatic amino acids in the discoidin domain of Paenibacillus β-1,3-glucanase
... a discoidin domain (DS domain), present in both eukaryotic and prokaryotic proteins with a wide variety of functions, exists at the ...DS domain in terms of its structure and function, this ...
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Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway
... Effector T cell migration through the tissue extracellular matrix (ECM) is an important step of the adaptive immune response and in the development of inflammatory diseases. However, the mechanisms involved in this ...
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Engineered Discoidin Domain from Factor VIII Binds αvβ3 Integrin with Antibody like Affinity
... the discoidin domain family, the three binding spikes demonstrate diversity as result of the range of ligands that the family can bind ...individual discoidin domain is only known to bind to a ...
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The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair
... repair. Discoidin domain receptors (DDRs) are a novel class of receptor tyrosine kinases that bind to several collagens and stimulate matrix metalloproteinase (MMP) production, but little is known about ...
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N-Glycosylation of the Discoidin Domain Receptor Is Required for Axon Regeneration in Caenorhabditis elegans
... We next asked at what point SVH-11 acts in the JNK pathway during axon regeneration. Overexpression of mlk-1 suppressed the regeneration defect observed in svh- 11(gk819558) and svh-11(km86) mutants (Figure 3, A and C ...
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Type I collagen aging impairs discoidin domain receptor 2-mediated tumor cell growth suppression
... The tyrosine phosphatase SHP-2, a specific downstream effector of DDR2 [29], is more phosphorylated in the presence of adult collagen when compared with the old one. This highly correlates with the differential ...
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ALK and ROS1 as targeted therapy paradigms and clinical implications to overcome crizotinib resistance
... Extensive translational studies have demonstrated that lung cancer is no longer a single disease, and the “all-in-one-way” approach is no longer applicable. To date, more than ten cancer driver genes have been identified ...
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Development of imatinibmesylate-induced interstitial lung disease 2 weeks after discontinuation of the treatment: a case report
... BAL: Bronchoalveolar lavage; DDR: Discoidin domain receptors; DLST: Drug lymphocyte-stimulating test; GIST: Gastrointestinal stromal tumor; HRCT: High-resolution computed tomography; ILD[r] ...
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Structural and functional analysis of muskelin.
... A number of natural disease-causing mutations in the kelch-repeat proteins RAG-2 and gigaxonin involve non-conservative substitutions of single residues within the kelch repeats. These are thought to disrupt the ...
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DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study
... The migration ability of urothelial carcinoma corresponding to dismal prognosis had not been fully investigated. The interaction of extracellular collagen with a unique transmembrane receptor tyrosine kinase, ...
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Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance
... ALK, anaplastic lymphoma kinase; BCR–ABLi, BCR–ABL inhibitor; BRAFi, BRAF inhibitor; CHK1, checkpoint kinase 1; DDR2, discoidin domain-containing receptor 2; EGFRi, EGFR inhibitor; EGFR,[r] ...
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A Krylov Space Based Finite Element Time Domain Method for Broadband Frequency Domain Solutions
... time domain approach for frequency domain ...time domain data, by which the corresponding frequency domain solutions of a wide range can be obtained with negligible computational costs once ...
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Domain and Time Domain Approaches in Forecasting Techniques
... Frequency Domain and Time Domain ...time domain analysis. There is duality between the frequency domain and time domain approaches to the time series ...
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The structure of the quality of clinical practice guidelines with the items and overall assessment in AGREE II: a regression analysis
... Development), Domain 4 (Clarity of Presentation), Domain 5 (Applicability), and Domain 6 (Editorial Independence) were found to have a significant influence on the overall ...assessment. ...
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Domain Adaptation for Medical Text Translation using Web Resources
... on domain focused web-crawling ...out- domain data from the crawled data, we not only explore text-to-topic classifier, but also propose an alternative filtering approach combined the existing one ...
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Development, reliability and validity of the Chichewa WHOQOL BREF in adults in lilongwe, Malawi
... Psychological domain (which has a higher mean score and is skewed towards 100) due to anecdotal evidence of an ‘it is well with my soul’ syndrome in ...transport—Environment domain) the scoring may be ...
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Automatic Domain Partitioning for Multi Domain Learning
... the domain labels in the dataset are ...automatic domain partitioning approach that aims at providing better domain identi- ties for ...the domain distance be- tween data instances , and then ...
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Domain Independent Captioning of Domain Specific Images
... ages with 27,450 labeled objects, in order to learn only 20 object classes. Since training visual recog- nition systems is such a burden, “general-domain” image captioning datasets are limited by the current ...
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Applications of reconstituted inflammasomes in a cell-free system to drug discovery and elucidation of the pathogenesis of autoinflammatory diseases
... PYD domain of AIM2 interacts with the HIN-200 domain of AIM2 loosely upon being incubated with no ...HIN-200 domain of AIM2, then the PYD domain of AIM2 apart from the HIN-200 domain of ...
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