DJ-1
Novel association of DJ-1 with HER3 potentiates HER3 activation and signaling in cancer
... identified DJ-1/PARK7 (Parkinson Protein 7) as a novel interaction partner of HER3 and demonstrated the potential of DJ-1 as a biomarker for anti-HER3 cancer ...therapy. DJ-1 ...
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The effects of DJ-1 and A20 family members on inflammation and oxidative response
... of DJ-1, it has been known that DJ-1 possesses an extra carboxy-terminal alpha helix not seen in the related PfpI family of ...of DJ-1 actually exists in human ...that ...
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Original Article Nucleus DJ-1/Park7 acts as a favorable prognostic factor and involves mucin secretion in invasive breast carcinoma in Chinese population
... expressed DJ-1/Park7 in cytoplasm and nucle- us as an internal control of ...nucleus DJ-1/Park7 was performed by light microscopy at × 400 ...≥ 1% tumor cells with nuclear staining ...
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Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1 −/− mice
... in DJ-1−/− mice following repeated, serial systemic low- dose LPS administration could be attributed to upregulation of anti-oxidant responses as a developmental consequence of DJ-1 ...or ...
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DJ-1 Deficiency Protects Hepatic Steatosis by Enhancing Fatty Acid Oxidation in Mice
... Obesity and T2DM are closely related to NAFLD and which are the main risk factors of it [21]. NAFLD is defined as liver diseases with hepatic excess lipid accumulation, especially TG, due to non-alcoholic causes. When ...
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Distinct Mechanisms of Pathogenic DJ-1 Mutations in Mitochondrial Quality Control
... first DJ-1-binding proteins (DJBP) to be identified, the DJBP (Niki et ...of DJ-1 mutations on the DJ-1/DJBP interaction, or other binding partners, and the pathophysiological ...
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DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes
... of DJ-1 in blood cells, it may be possible to determine the extent of MWCNT ...in DJ-1 protein expression, regardless of the cytotoxic activity of intracellular ...in DJ-1 mRNA ...
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Methylation status of DJ 1 in leukocyte DNA of Parkinson’s disease patients
... of DJ-1 has been ...of DJ-1 in the peripheral blood between PD and NC groups and determine whether DNA methylation of DJ-1 in peripheral blood could represent the reduced ...
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DJ-1 can inhibit microtubule associated protein 1 B formed aggregates
... of DJ-1 can enhance the death of proteasome inhibitor-treated Neuro2A cells [25], so we attempted to assess whether DJ-1 deficiency may affect the proteasome ...of DJ-1 KD cells ...
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Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation
... in DJ-1 KO mice compared to WT ...and DJ-1 KO mice except that of MCP-1 and CCL5, which are not related to neutrophil infiltration (Supplementary Figure ...in DJ-1 KO mice ...
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Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma
... both DJ-1 and PTEN in SSCC tissue versus adjacent non-cancerous ...of DJ-1 was mainly in SSCCs and less frequently in adjacent non-cancerous tissues, whereas PTEN staining of adjacent ...
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CPX Targeting DJ-1 Triggers ROS-induced Cell Death and Protective Autophagy in Colorectal Cancer
... of DJ-1. Loss of DJ-1 protein results in the mitochondrial dysfunction, which leads to the accumulation of ROS, thus inhibiting cell proliferation and inducing ...of DJ-1 ...
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Parkin, PINK1, and DJ 1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
... and DJ-1 in human brain ...and DJ-1 (Figure 1I), suggesting that Parkin, PINK1, and DJ-1 form a complex in ...and DJ-1 were identified (Supplemental Table ...and ...
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Studies of DJ-1, Parkin and Alpha-Synuclein Give Insights into Plausible Mechanisms for Parkinson's Disease Pathogenesis.
... of DJ-1 protein shows that the L166P mutation occurs in helix 7, which is one of the helices in the dimer interface of DJ-1 ...E163K DJ-1 dimerizes under native conditions, size ...
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Original Article Quercetin improves rat brain function after ischemia by regulating DJ-1/Nrf2
... group, DJ-1 and Nrf2 protein levels in brain tis- sues of the IR group were markedly ...group, DJ-1 and Nrf2 protein expression in brain tissues of the Quer treat- ment group was further en- ...
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Overexpression of DJ-1 correlates with aggressive clinicopathological characteristics and poor prognosis in malignant tumors: a meta-analysis
... of DJ-1, sample size in each groups, age and gender of patients, end point, the source of hazard ratio (HR) (univariate or multivariate analysis), HR and correspond- ing 95% confidence interval (CI), ...
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DJ-1 promotes survival of human colon cancer cells under hypoxia by modulating HIF-1α expression through the PI3K-AKT pathway
... Nucleoproteins were extracted using a Nucleoprotein Extraction Kit (Sangon Biotech). Protein concentrations were determined according to the Bradford method using BCA assay reagent (Beyotime, Beijing, China). Samples (25 ...
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Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients
... fraction DJ-1 levels in PD and NPC: ...of DJ-1 high molecular weight complex and total DJ-1 was normalized to CoxIV level and indicated in percentage to NPC ...
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Absence of Dopaminergic Neuronal Degeneration and Oxidative Damage in Aged DJ-1-deficient Mice
... of DJ- 1 protein are significantly increased in PD brains and cer- ebrospinal fluids, and DJ-1 is oxidatively damaged in the brains of patients with sporadic PD ...that DJ-1 ...
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L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL
... Figure 1 Subcellular distribution of wild-type DJ-1 and DJ-1(L166P) in ...(control), DJ-1-Myc or DJ-1(L166P)-Myc along with Mito-EGFP were subjected to ...
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