DNA Breaks
Neutrophil derived microRNAs put the (DNA) breaks on intestinal mucosal healing
... double-strand DNA breaks (DSBs) in intestinal epithelial cells by shuttling microRNA-containing microparticles ...on DNA damage. Neutrophil-derived micro- particles alone induced DNA damage ...
5
The Activation of ATR in Response to Double-Stranded DNA Breaks
... DNA replication is a delicate, spatially and temporally coordinated process where the sequential assembly of factors onto DNA ensures that the genome of each cell is faithfully replicated once per cell ...
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ALTERATIONS OF ADP-RIBOSYLATION AND DNA-BREAKS IN AGING BRAIN CELLS
... provoke DNA damage or strand breaks produced an activation of the ADP- ribosyl polymerase ...of DNA breaks of the cellular fractions, suggest that the neurons are more susceptible to the ...
5
Multiple Pathways Suppress Telomere Addition to DNA Breaks in the Drosophila Germline
... sperm DNA even in the presence of abundant maternal deposition of capping compo- nents (our unpublished data); and second, DNA repair, par- ticularly end joining, is highly active during the early embryonic ...
13
Predicting double strand DNA breaks using epigenome marks or DNA at kilobase resolution
... of DNA motifs and DNA shape ...resulting DNA repair mecha- nisms have been shown to be linked to epigenome marks, including H3K4me1/2/3 and chromatin accessibility ...of DNA-repair proteins at ...
14
Human cytomegalovirus UL76 induces chromosome aberrations
... induces DNA breaks in proportion to its protein levels, and marginally subverts mitotic fidelity by inducing aberrant spindles and super- numerary centrosomes relative to control ...
10
Evaluation of DNA Integrity of Cryopreserved Boer Goat (Capra hircus) Sperm Using Comet Assay at Various pH Conditions
... double-strand DNA breaks (neutral comet assay) were significantly higher than single-strand DNA breaks (alkaline comet ...double-strand DNA breaks compare to the single- strand ...
6
DNA Damage-Inducible and RAD52-Independent Repair of DNA Double-Strand Breaks in Saccharomyces cerevisiae
... pendent experiments are plotted. Figures 4–6 compare, respectively, chromosomal bands, PFGE migration profiles, and estimates of the numbers of DSBs produced in chromosomes from RAD52/ the spatial separation of ...
15
“Breaking news” from spermatids
... to DNA damage and DNA double-strand breaks (DSBs) are observed ...minated DNA adopts a completely different topology as the somatic-like DNA supercoiling is lost and planar toroids are ...
5
The Role of the Ku70 vWA Domain in the Response to DNA Double Strand Breaks
... Ku70 wild-type (WT), Ku70 S155A/D156A or empty pMSCV either untreated (control) or immediately after IR (0h), 2h or 6h following IR treatment. For all samples, FAR (fraction of activity released) was averaged from 3 ...
220
Biological responses of white sea bream (Diplodus sargus, Linnaeus 1758) and sardine (Sardine pilchardus, Walbaum 1792) exposed to heavy metal contaminated water
... of DNA breaks in comet assay indicates either elevated damage rate or repair approach (Collins et ...that DNA damage reached the highest percentages in El Max site followed by Bahary area and the ...
7
DNA-PK Deficiency in Alzheimer's Disease
... Reduced DNA repair ability has been reported in AD ...double-strand DNA breaks (DSB) is non-homologous end joining (NHEJ) that requires DNA-dependent protein kinase (DNA-PK) ...
6
The Large Subunit of Replication Factor C (Rfclp/Cdc44p) Is Required for DNA Replication and DNA Repair in Saccharomyces cerevisiae
... induced single-stranded DNA breaks at the restrictive temperature is consistent with the hypothesis that Cdc44p plays a role in the DNA excision repair pathway.. DISCUSS[r] ...
14
EXTRACTION OF URSOLIC ACID FROM OCIMUM SANCTUM: MODULATORY EFFECT OF URSOLIC ACID ON HYDROGEN PEROXIDE INDUCED DNA DAMAGE IN HUMAN LYMPHOCYTES
... of DNA strand breaks by FADU is based on partial denaturation (unwinding) of double-stranded DNA under controlled alkaline and temperature ...conditions. DNA strand breaks are sites ...
10
Exposure to ultraviolet radiation causes apoptosis in developing sea urchin embryos
... on DNA, as observed through the accumulation of CPD photoproducts, and the positive TUNEL assay, which indicates the occurrence of DNA strand breaks caused by ROS (Imlay and Linn, 1988; Pourzand and ...
7
Molecular Mechanisms of H. pylori Induced DNA Double-Strand Breaks
... and DNA-unwinding activities as well as DNA-binding and DNA end-bridging properties ...pathway, DNA-dependent protein kinase (DNA-PK), which consists of DNA-PK catalytic subunit ...
30
Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease
... oxidative DNA damage [25]. Notably, increased levels of DNA damage in aging brains are associated with the reduced expression of essential genes, including genes involved in neuronal plasticity ...Neuronal ...
18
Advances in using PARP inhibitors to treat cancer
... in DNA damage that is repaired by a variety of mechan- isms, including base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER), single strand annealing (SSA), homologous recombination ...
5
Increased single strand breaks in DNA of lymphocytes from diabetic subjects
... glycohemoglobin values above or below 9%. The group with glycohemoglobin values of 12.9 +/- 2.4% (mean +/- SD), but not the group with glycohemoglobin values of 7.4 +/- 1.5%, showed accelerated unwinding of lymphocyte ...
5
Effects of TiO2 and Co3O4 Nanoparticles on Cell Cycle of a Pulmonary Cell Line (A549)
... Regulation of the cell cycle involves processes crucial to cell survival, including the detection and repair of genetic damage to ensure that damaged or incomplete DNA is not passed on to daughter cells. The ...
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