DNA damage binding protein
In silico characterization of a novel pathogenic deletion mutation identified in XPA gene in a Pakistani family with severe xeroderma pigmentosum
... by DNA sequencing revealed a novel deletion mutation ...terminates protein and result into a truncated product of 222 amino acid (aa) residues instead of 273 ...mutated protein with binding ...
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Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage
... UV-damaged DNA, cisplatin-modified DNA, as well as single-stranded DNA with high affinities ...damaged-DNA binding activity of DDB2 has been implicated in its nucleotide excision repair ...
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binding to p53 on the p21 WAF1/CIP1 promoter blocks transcription resulting in cell death
... that DNA-PK CS and p53 form a protein-protein complex ...four DNA damage ...a DNA-PK CS /p53 protein complex that was not detected following doxorubicin treatment or IR ...
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Silibinin enhances the repair of ultraviolet B-induced DNA damage by activating p53-dependent nucleotide excision repair mechanism in human dermal fibroblasts
... the DNA strand at the 3′ extreme of DNA damage, and XPG binding stabilizes the pre-incision complex and it is essential for 5′ end cleavage by the ERCC1/XPF endonuclease [11, ...the ...
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Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53 binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus induced DNA damage response
... to DNA damage, localizes to HPV rep- lication compartments, inside nuclear foci, whose size directly increases together with virus productive replica- tion ...viral DNA, suggesting the enrollment of ...
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A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein
... vitro DNA transfection reagent (FroggaBio) with a DNA-to-PolyJet ratio of ...EBV protein BBLF2/3 was detected through its myc tag with anti-c-myc monoclonal antibody 9E10 (Santa Cruz Biotechnology; ...
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Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A X during mouse preimplantation development in the absence of DNA damage
... We have found that levels of γ H2A.X are sustained in the embryo in the absence of induced DNA damage. This is in line with previous reports documenting phosphorylation of H2A.X independent of DNA ...
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Ran Binding Protein 9 (RanBP9) is a novel mediator of cellular DNA damage response in lung cancer cells
... RanBP9 is found in both the nucleus and the cytoplasm and a recent report identified different regions of the protein that might be involved in its nuclear localization [34]. However, the molecular mechanisms ...
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Candida albicans RFX2 Encodes a DNA Binding Protein Involved in DNA Damage Responses, Morphogenesis, and Virulence
... chromosomal DNA was removed by treatment with DNase I and removal reagents provided in the RiboPure-Yeast ...genomic DNA contamination was con- trolled by including the constitutively expressed housekeeping ...
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Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection
... E1B55K protein was identified as a binding partner ...No binding of GST or GST-PRMT1 to E1B55K proteins was ...Nuclear DNA is stained with ...
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Genetic Evidence of a Role for ATM in Functional Interaction between Human T-Cell Leukemia Virus Type 1 Tax and p53
... Tax protein subverts p53 ...cellular DNA damage (86), and it cannot bind to the human homologue of the Drosophila disc large tumor suppressor pro- tein, ...hDlg. Binding of hDlg (49, 90), ...
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Promyelocytic leukaemia protein isoform II and mild heat stress compromise human adenovirus type 5 gene expression
... late protein expression was very well reflected at the RNA level since the L3 hexon, L1 IIIa and L2 penton were expressed at approximate 50, 10 and 50 fold lower levels ...Ad5 DNA replication during the ...
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Adenovirus Type 5 DNA Binding Protein Stimulates Binding of DNA Polymerase to the Replication Origin
... Enhanced binding of Pol correlates with enhanced stimula- tion of ...Pol binding? To address this issue we compared templates TD50 and T50, showing the two outermost situations in stimulation, in an EMSA ...
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Studies of the Silencing of Baculovirus DNA Binding Protein
... The reduction in capsid and polyhedrin proteins suggested that virus assembly may be affected by the suppression of DBP. Thus, electron microscopy (EM) studies were performed. Cells transfected with either GFP or DBP ...
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Multiple regions within EBNA1 can link DNAs.
... acting DNA-linking activity exist within ...a DNA with five GAL4-binding sites linked by 15 m l of a crude extract of ...linked DNA was determined), and the disappearance of unbound DNA ...
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Thrombin activates a Y box–binding protein (DNA binding protein B) in endothelial cells
... new DNA-bind- ing activity was detected by EMSA. The protein that was revealed by incubation with alkaline phosphatase exhibited the same electrophoretic mobility and DNA- binding properties ...
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DNA-binding protein associated with herpes simplex virus DNA polymerase.
... Again, the protein was eluted by a gradient of 0 to 0.4 M KCI, and the fractions indicated by the solid horizontal line which were found to contain ICSP 34, 35 were pooled, dialyzed, and[r] ...
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Review on DNA damage, repair and DNA sequencing
... UV damage, alkylation/methylation, X-ray damage and oxidative damage are examples of induced ...Spontaneous damage can include the loss of a base, deamination, sugar ring puckering and ...
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Mechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124.
... (DNA binding buffer) for 50 min on ...of protein A-Sepharose beads in NET buffer (50 mM Tris z HCl [pH ...in DNA binding buffer before addition to the T antigen-DNA ...
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Monoclonal Antibodies against the Minimal DNA-Binding Domain in the Carboxyl-Terminal Region of Human Immunodeficiency Virus Type 1 Integrase
... MAb binding on in vitro activities of ...MAb binding on HIVIN activities was measured relative to the result obtained in a reaction with MAb reactive to the hexahistidine tag (100% ...
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