DNA damage-binding protein 1
Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection
... a DNA damage response (DDR), seen as the phosphorylation of a number of well-characterized ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) substrates ...cellular DNA or perhaps ...
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Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A X during mouse preimplantation development in the absence of DNA damage
... the DNA damage response as well as its putative role in assembly of embryonic chromatin, we started by analysing its distribution in the preim- plantation mouse ...of DNA damage in freshly ...
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Structural alteration of DNA induced by viral protein R of HIV 1 triggers the DNA damage response
... the protein synthesis, WGE was diluted in 3× vol- ume of StA binding Buffer (50 mM Tris–Cl [pH ...NaCl, 1 mM EDTA, 1% NP40, ...StA binding buffer, and eluted by 1×SA elution ...
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Drosophila Damaged DNA-Binding Protein 1 Is an Essential Factor for Development
... damaged DNA-binding protein (DDB) com- tants) are selectively defective in global genomic repair plex, which is a heterodimeric protein composed (GGR; Hwang et ...of DNA lesions (2002) ...
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In silico characterization of a novel pathogenic deletion mutation identified in XPA gene in a Pakistani family with severe xeroderma pigmentosum
... Replication protein A (RPA), Exci- sion repair cross complementing group 1(ERCC1), DNA damage-binding protein 2 (DDB2), transcription factor II H (TFIIH) and as well as to UV- or ...
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Candida albicans RFX2 Encodes a DNA Binding Protein Involved in DNA Damage Responses, Morphogenesis, and Virulence
... hour. Following incubation, the cells were vacuum filtered through prewet 20- mm-diameter polycarbonate filters with 10- m pore size (Millipore, Billerica, MA) mounted on a filter manifold (Millipore, Bedford, MA). ...
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Human papillomavirus type 16 E6 and E7 oncoproteins interact with the nuclear p53 binding protein 1 in an in vitro reconstructed 3D epithelium: new insights for the virus induced DNA damage response
... HPV16 DNA detection was performed onto the normal and HPV16 positive 3D tissues as described by Peh et ...HPV16 DNA probe (cloned in pBR322 vector, kindly obtained by the Karolinska Institute, International ...
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A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein
... For protein and peptide identification, RAW files were submitted for database searching using X! TANDEM (version ...UniProt/Swiss-Prot protein database FASTA ...
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Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage
... mechanism that is used by the chemotherapy drugs to eliminate cancer cells. Many of the chemotherapy drugs are also DNA-damaging agents, and they function by inducing apoptosis. Stoyanova et al. demonstrated that ...
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Genetic Evidence of a Role for ATM in Functional Interaction between Human T-Cell Leukemia Virus Type 1 Tax and p53
... Tax protein subverts p53 ...cellular DNA damage (86), and it cannot bind to the human homologue of the Drosophila disc large tumor suppressor pro- tein, ...hDlg. Binding of hDlg (49, 90), ...
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Prediction on DNA Binding Sequence in Deep Learning Approach
... of DNA- binding proteins only from primary sequences utilizes two stages of convolutional neutral network to detect the function domains of protein sequences, and the long short-term memory neural ...
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Silibinin enhances the repair of ultraviolet B-induced DNA damage by activating p53-dependent nucleotide excision repair mechanism in human dermal fibroblasts
... Expression of the NER factors and other DNA damage repair regulators (p53, p21 and GADD45α) was analyzed by immunofluorescence using a confocal microscope. Briefly, NHDFs were seeded onto coverslips, and ...
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Genome sequence and description of Timonella senegalensis gen. nov., sp. nov., a new member of the suborder Micrococcinae
... All key proteins and protein complexes known to be important in aerobic complexes are present in the genome of T. senegalensis , including genes re- sponsible for the synthesis of terminal cyto- chrome or quinol ...
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Cloning and expression of an equine herpesvirus 1 origin-binding protein.
... In order to confirm that the C-terminal DNA-binding domain of EHV-1 OBP was mediating the same sequencespecific binding as the wild-type protein, in vitro-expressed del 1-499 was used to[r] ...
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The human T transcription factor: A study of genetics and function
... shorter protein products could result from protein degradation, although protease inhibitors were included in the transcription/translation ...the protein degradation hypothesis. T he synthetic hum ...
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The DNA Binding Domain of a Papillomavirus E2 Protein Programs a Chimeric Nuclease To Cleave Integrated Human Papillomavirus DNA in HeLa Cervical Carcinoma Cells
... E2 protein can be used to direct nuclease domains to induce site-specific DNA double-strand breaks at E2 BSs in cervical cancer ...of DNA double- strand ...the protein or varying the exact ...
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Azithromycin suppresses interleukin-12p40 expression in lipopolysaccharide and interferon-γ stimulated macrophages
... end-labeled DNA probes instead of radioactive probes. Nuclear protein (4 μ g) was incubated with labeled probes for 20 min at room ...end-labeled DNA was detected according to the manufacturer’s ...
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Reversal of glycoxidative damage of DNA and protein by antioxidants
... In the present study, the effect of some commonly used natural compounds (eugenol, melatonin, mannitol, sodium acetate and sodium azide) was checked on the process of glycation of proteins. The amount of glycation ...
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Adenovirus DNA-binding protein forms a multimeric protein complex with double-stranded DNA and enhances binding of nuclear factor I.
... 1 0022-538X/90/010379-08$02.00/0 Copyright C 1990, American Society for Microbiology Adenovirus DNA-Binding Protein Forms a Multimeric Protein Complex with Double-Stranded DNA and Enhanc[r] ...
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Hepatitis C Virus Indirectly Disrupts DNA Damage Induced p53 Responses by Activating Protein Kinase R
... core protein in HepG2/miR-122 cells electroporated with genome-length HCV RNA (JFH1-QL) or a nonreplicating control RNA (JFH1/GND) and treated 72 h later with 100 M etoposide (ETOP) or DMSO for 2 ...core ...
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