DNA damage, mutation and other effects
A Review of Probable Effects of Antioxidants on DNA Damage
... neutralizing effects against ROS and DNA damage but some studies are controversial; so, determining the effective dosage needs further studies ...
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Effects of The BCR-ABLl Oncogene on DNA Damage and Repair
... in DNA damage or impairs DNA repair ...these effects are modest and there is not a consensus as to the critical DNA repair mechanisms affected by BCR-ABL ...after DNA ...
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ALS associated mutation FUS R521C causes DNA damage and RNA splicing defects
... FUS mutation (FUS-R521C mice), we found that mutant FUS proteins formed a stable complex with WT FUS proteins and interfered with the normal interactions between FUS and histone deacetylase 1 ...of DNA dam- ...
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ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects
... FUS mutation (FUS-R521C mice), we found that mutant FUS proteins formed a stable complex with WT FUS proteins and interfered with the normal interactions between FUS and histone deacetylase 1 ...of DNA dam- ...
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DNA Damage Effects of A Polyamide-CBI Conjugate in SV40 Virions
... SV40 DNA replication via encapsidated viral DNA damage, 1-CBI was tested for similar activity in terms of virus ...days. Effects on virus production were assessed by plaque formation assay, a ...
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Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers
... BRCA2 mutation carriers demonstrate age-associated deregulation of epithelial cell proportions compared to ...BRCA2 mutation carriers following sorting via CD49f and EpCAM ...subtle effects on ...
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Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53
... missense mutation occurred in a small subunit of DNA primase (Prim1) in the piy ...for DNA replication. However, this missense mutation does not affect cell proliferation, suggesting that this ...
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The Effects of Variable Mutation Rates Across Sites on the Phylogenetic Estimation of Effective Population Size or Mutation Rate of DNA Sequences
... Under the neutral Wright-Fisher model without re- combination and population subdivision, we study the effects of multiple hits due to mutation rate heterogene- ity among s[r] ...
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Singular v Dual inhibition of SNF2L and its isoform, SNF2LT, have similar effects on DNA Damage but opposite effects on the DNA Damage Response, Cancer Cell Growth Arrest and Apoptosis
... inhibition, DNA damage, a DNA damage response, and phosphorylation of checkpoint proteins and marked ...similar effects to the knockdown of its parental molecule, SNF2L, of inducing ...
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The Protective Effects of Melatonin on the Monocrotophos and Quinalphos Induced Oxidative DNA Damage in Rats
... of DNA damage are expressed as damage index calculated as #0 + #1 + #2 + #3 + #4/ # of cell scored where # is the total number of nuclei ...oxidative DNA damage in rat tissues and ...
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A Point Mutation in the Aspergillus nidulans sonBNup98 Nuclear Pore Complex Gene Causes Conditional DNA Damage Sensitivity
... a mutation encoding a single amino acid substitution within the Aspergillus nidulans SONBn Nup98 NPC protein ...this mutation causes marked DNA damage sensitivity at ...2 DNA ...
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Synergistic Effects of Andrographolide on DNA Damage Repair Mechanism and Apoptosis in Breast Cancer Cells
... cytotoxic effects of andrographolide in MDA-MB-231 cells with and without ...of DNA damage repair response proteins including FANCJ, FANCD2, RAD51, pRPA32 and ...of DNA damage repair ...
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Preceding exercise and postprandial hypertriglyceridemia: effects on lymphocyte cell DNA damage and vascular inflammation
... the effects of PHTG, and especially exercise, persist for several hours after the initial exposure so including further postprandial measures (beyond 6 h) and possibly into the following days, may provide deeper ...
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A novel mutation in DNA topoisomerase I of yeast causes DNA damage and RAD9-dependent cell cycle arrest.
... Extracts from a strain express- ing wild-type TOPI (NLY 107) fully convert the super- coiled substrate plasmid to the relaxed form, whereas extracts from the isogenic topl[r] ...
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DNA Damage and Mutation Caused by Vital Biomolecules, Water, Nitric Oxide, and Hypochlorous Acid
... cause DNA damage. Without complete repair, mutations will occur by DNA replication, and the accumulation of mutations may cause ...the DNA of cells at the chronic in‰ammation site is exposed ...
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Modulation of the p53 response: Effects of DNA damage and MDM2 overexpression
... irradiation damage such as UV and X- ray, cellular responses are thought to reflect the degree of damage ...Frank damage assessment determines apoptosis when cellular damage is beyond feasible ...
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Effects of cryopreservation on mitochondrial function and DNA damage of bovine sperm
... that DNA damage increased during incubation up to 24h using the SCSA ...in DNA damage of bovine sperm before cryopreservation during an incubation time of ...cause DNA damage, ...
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Effects of trypsin on cellular, chromosomal and DNA damage induced by X rays
... Culture: methods and applications.(ed. London: Academic Press. The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells. Association of globin ribonucleic acid[r] ...
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The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair
... tail DNA) in glioblastoma stem-like cells treated with protons in comparison to 320 kV X-rays, particularly at 20–48 h post-irradiation, which was associated with a higher level of apoptosis [ 33 ...
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Geant4-DNA simulation of DNA damage caused by direct and indirect radiation effects and comparison with biological data.
... the DNA molecule and the probability of detecting nuclear foci after targeted microbeam irradiation of cells with protons and alpha particles of different ...a DNA target model induced by direct and ...
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