DNA Damage Repair
β2-spectrin depletion impairs DNA damage repair
... regulation, DNA repair, and TGF-β signaling [11, 14, ...in DNA damage repair by the homologous recombination (HR) pathway in response to various exogenous ...
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Targeting deficient DNA damage repair in gastric cancer.
... One treatment combination of particular interest is with immunotherapy. Immunotherapy represents a significant breakthrough in oncology and has shown promise in gastric cancer. One of the current challenges of ...
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The role of ChlR1 in DNA replication, DNA damage repair and cohesion establishment
... in DNA damage repair and cancer development is the association of FHL2 with BRCA1 ...in DNA damage ...oxidative DNA damage and double strand break repair through HR ...
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DNA damage repair in ovarian cancer: unlocking the heterogeneity
... In vitro studies have found an association between MMR deficiency and resistance to platinum agents and DNA methylating agents such as 6-thioguanine, due to an in- activation of MMR driven apoptosis in ovarian ...
12
Review on DNA damage, repair and DNA sequencing
... of DNA damage affects of the double helix; that is, the bases themselves are chemically ...RNA, DNA usually lacks tertiary and therefore damage or disturbance does not occur at that ...level. ...
6
The function of CUX1 in oxidative DNA damage repair is needed to prevent premature senescence of mouse embryo fibroblasts
... Using 8-oxoG cleavage assays with purified proteins, we previously showed that various combinations of Cut repeats and the Cut homeodomain (CR1CR2, CR3HD and CR2CR3HD) are able to stimulate the glycosylase activity of ...
14
DNA Damage, Repair, and Cancer Metabolism.
... and DNA damage/DNA repair in cancer has yet to be appreciably ...connecting DNA damage and repair mechanisms with cell metabolism through three principal ...impact ...
8
Chromatin structure and DNA damage repair
... UV irradiation not only causes an increase of H2A ubiqui- tination, but also induces a temporary H3 and H4 ubiqui- tination [89]. A complex containing UV-DDB and CUL4A was required for this ubiquitination. H3 and H4 ...
13
DNA damage induces nuclear translocation of parkin
... in DNA damage repair, I examined whether parkin associated with damaged ...when DNA was damaged by UV irradiation ...with damage DNA also occurred in human brain tissues with ...
9
Effect of Repeated Injection of Cadmium on Bax/Bcl-2 mRNA Level in Stomach of Rats
... of DNA damage repair, suppuration of apoptosis, and induction of oxidative stress, the formation of reactive oxygen species (ROS), interference with anti- oxidative enzymes, inhibition of DNA ...
8
Advances in using PARP inhibitors to treat cancer
... if DNA damage is selec- tively increased in tumor compared to normal tissues, such as the gastrointestinal mucosa or bone ...harbor DNA repair defects. Simulta- neous dysfunction of two ...
5
Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC -deficient cells
... the DNA lesion-forming potential and repair or tolerance ...of DNA adducts is that IPMS is able to form a carbonium ion (S N 1) while the reactivity of nPMS occurs via a bimolecular nucleophilic ...
14
<p>Digital Immune-Related Gene Expression Signatures In High-Grade Serous Ovarian Carcinoma: Developing Prediction Models For Platinum Response</p>
... is DNA damage, different DNA-damage repair systems stand in the focus of research for the prediction of platinum response, 5,30 including nucleotide excision repair, mis- match ...
13
Stationary Phase Persisters to Ofloxacin Sustain DNA Damage and Require Repair Systems Only during Recovery
... less damage than their dying ...antibiotic-induced damage that is indistinguishable from that of ...required DNA repair for survival and that repair machinery was unnecessary until the ...
11
The Homologous Recombination Repair Pathway is Associated with Resistance to Radiotherapy in Nasopharyngeal Carcinoma
... of DNA lesions, which in replicating cells often results in deleterious DNA double-strand breaks (DSBs) ...in DNA damage repair in nonprolifera- ting cells, thus inhibiting NHEJ is ...
12
Mismatch Repair Mutants in Yeast Are Not Defective in Transcription-Coupled DNA Repair of UV-Induced DNA Damage
... coli mis- match repair mutants, we found that mutations in yeast mismatch repair genes had no discernable effect upon either transcription-coupled repair or global nucleotide [r] ...
9
A New Epistasis Group for the Repair of DNA Damage in Bacteriophage T4: Replication Repair
... The increased UV sensitivity caused by amA453 is additive to that caused by mutations in both the T4 excision repair (denV) and recombination repair (uvsWXY) systems, suggesting[r] ...
13
Repair of Topoisomerase-Mediated DNA Damage in Bacteriophage T4
... that repair from the topo site tional repair about fourfold with either the topo site or requires the same recombinational repair proteins as the I-TevI site, suggesting a role for this protein in ...
10
ANTIOXIDANT CAPACITY OF THE METHANOLIC EXTRACT OF SOLANUM TORVUM LEAVES
... damages. [2] Solanum torvum is a small shrub commonly known as ‘Turkey berry’. It is widely distributed in India, Pakistan, Malayan, China, Philippines, Thailand and tropical America. [3,4] Its edible fruits are used as ...
8
Walter, Joachim (2003): Dynamics of DNA-repair factors and chromosomes studied by laser-UVA-microirradiation and laser-photobleaching. Dissertation, LMU München: Fakultät für Biologie
... the damage introduced by this method is - at least presently - less well characterized than that introduced by “classical” irradiation methods as ionizing irradiation or UV ...unspecific damage and ...
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