DNA damage response (DDR)
Host DNA Damage Response Factors Localize to Merkel Cell Polyomavirus DNA Replication Sites To Support Efficient Viral DNA Replication
... host DNA damage response (DDR) and MCPyV ...ATR-mediated DDR pathways accumulate in MCPyV large T antigen (LT)-positive nuclear foci in cells infected with native MCPyV ...episomal ...
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Scorpins in the DNA Damage Response
... The DNA damage response (DDR) is an attractive target for anti-cancer treatments due to the increased genotoxic stress that malignant cells experience[1] ...the damage are limited to a ...
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Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes
... are simple privileged molecules, and, although various chalcones have anti-cancer activities, some of their molecular targets have not been fully validated [29]. Therefore, an improved understanding of their mechanisms ...
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The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF kappaB activation
... the DNA damage response (DDR) is also known to result in the activation of the NF-κB signaling pathway, a phenomenon known as nucleus to cytoplasm or “inside-out” NF-κB signaling [26–28], ...
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DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway
... the DNA damage response (DDR) for the cellular resistance to ICLs ...the DNA repair factors including HR proteins BRCA2 (FANCD1), BRIP1 (FANCJ), PALB2 (FANCN), RAD51C (FANCO), RAD51 ...
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Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... programmed response triggered in normal cells experiencing various types of stimuli, including telomere erosion [1-3], DNA damage [4], induction of oncogenes [5] and oxidative stress ...in ...
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Age-related dysfunction of the DNA damage response in intestinal stem cells
... occurring DNA damage are removed by the DNA damage response ...This response induces DNA repair and apoptosis; therefore, its dysregulation leads to accumulation of ...
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DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
... that DNA damage response (DDR) signaling is a key mechanism linking DNA damage accumulation, cell senescence, and organism ...aging. DDR activation in senescent cells ...
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The Smc complexes in DNA damage response
... cellular DNA damage ...in DNA repair and their cell cycle regulation by posttranslational modifications, such as acetylation, phosphorylation, and ...promote DNA repair and genomic stability ...
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Activation of the DNA Damage Response Is a Conserved Function of HIV 1 and HIV 2 Vpr That Is Independent of SLX4 Recruitment
... the DNA damage re- sponse by Vpr. While we found activation of the DNA damage response to be conserved, our results suggest that SLX4 recruit- ment by Vpr is not conserved by HIV-1, ...
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Roles of Ubiquitination and SUMOylation in DNA Damage Response
... Notably, each ubiquitin contains seven lysine residues. Addition of a ubiquitin to a prior ubiqui- tin molecule can be linked through each of seven lysine residues in ubiquitin, or through a head-to- toe ligation, ...
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Bocavirus Infection Induces a DNA Damage Response That Facilitates Viral DNA Replication and Mediates Cell Death
... The DDR that is induced during simian virus 40 (SV40) infection has been suggested to be activated by the large T antigen via Bub1 binding ...ATM-mediated DDR upon HPV infection of dif- ferentiated ...
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A Synthetic Circuit For Control Of The Bacterial Dna Damage Response Without Dna Damage
... which DNA photoproducts may lead to cell death, and the timeframe in which DNA repair must occur for an adequate response, are incompletely ...UV-induced DNA damage from activation of ...
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Development and clinical applications of cancer immunotherapy against PD-1 signaling pathway
... the DNA damage response (DDR) pathway, and such DDR variants have also been dis- covered in numerous tumors ...unfavorable response to immune checkpoint ...
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Evidence for a pre-malignant cell line in a skin biopsy from a patient with Nijmegen breakage syndrome
... the DNA damage response (DDR) net- work, which is, amongst others, involved in cell cycle checkpoint control, telomere maintenance, and ...defective DDR show a highly in- creased cancer ...
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Emerging roles of telomeric chromatin alterations in cancer
... from DNA damage response and from DNA repair ...of DNA repair pathways, resulting in telomeric ...R-loops, DDR, and maintenance of telomere length ...
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Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells
... diacetate; DDR: DNA damage-response; DDS: drug delivery systems; DEF: radiation dose enhancement factor; DMPK: drug metabolism and pharmacokinetic; DMSO: dimethyl sulfoxide; DOTA: ...
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checkpoint following DNA damage by doxorubicin during transient mitotic arrest
... but DNA damage can cause genomic instability by inducing mutations within chromosomal ...against DNA damage. During the checkpoint process, cells recognize DNA damage and stop ...
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p16 and ARF: activation of teenage proteins in old age
... in response to DNA damage (21, ...to DNA damage as a major factor inducing senescence: (a) telomere shortening induces senes- cence by activation of the DNA-damage ...
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Phosphatases in the cellular response to DNA damage
... cellular response to DNA damage. The DNA damage response network is composed of a large number of proteins with different functions that detect and signal the presence of ...
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