DNA double-strand break (DSB)
Evaluation of Ameliorative Potential of Vitamins E and C on DNA Double Strand Break (DSB) in Patients Undergoing Computed Tomography (CT): A Clinical Study
... of DNA double strand break (DSB) caused by CT ...of DSB was performed using γ-H2AX method as a sensitive ...the DSB (<3%, P ...
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Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.
... Unrepaired DNA double- strand breaks (DSB) are the principal lesions that determine responses in tumours and normal tissues, following treatment with radiation and/or several cytotoxic agents ...
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Tying the loose ends together in DNA double strand break repair with 53BP1
... including DNA double-stranded breaks (DSBs), through the activation of DNA damage response signaling ...during DNA replication, or through immunoglobulin heavy chain (IgH) rearrangements in B ...
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Evidence for conservative (two-progeny) DNA double-strand break repair.
... Intramolecular double-strand break repair in the RecE pathway (in a recBC sbcA strain): As our aim is in demonstration of intramolecular recombination and, therefore, cons[r] ...
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The Relative Biologic Effectiveness versus Linear Energy Transfer Curve as a Cell Trait
... the DNA double strand break (dsb) repair pathway; and the context is cellular stress responsing to DNA damage by both external stimuli and internal redox ...of DNA ...
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Regulation of DNA Double-Strand Break Repair by
... Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in. 780[r] ...
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Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51.
... Synthetic sensitivity of haploid 5-932 mutants to DNA damage: Our observations show that dominant-nega- tive alleles of RAD52 similarly suppressed the W and MMS sensitivi[r] ...
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Coordination of DNA Ends During Double-Strand-Break Repair in Bacteriophage T4
... of DSB ends during repair: The coconversion assay was modi- fied to address whether the two ends of a DSB are coordinated during repair as suggested by the Szostak et ...the break are repaired ...
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Meiotic Recombination Involving Heterozygous Large Insertions in Saccharomyces cerevisiae: Formation and Repair of Large, Unpaired DNA Loops
... ble-strand break (DSB) and repair of that break with matched templates can lead to gene conversion or resto- sequences derived from the homologous chromosome ration of Mendelian segregation ...
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DNA-PK Deficiency in Alzheimer's Disease
... of DNA repair systems such as base excision repair (BER), nucleotide excision repair (NER), single strand break repair (SSBR), and double strand break repair ...various ...
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Original Article Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan
... of DNA double strand break, showed that its expression was significantly increased in foci of BilIN, IPNB and invasive carcinoma as well as in non-neoplastic biliary epithelial cells of the ...
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Strand Invasion and DNA Synthesis From the Two 3′ Ends of a Double-Strand Break in Mammalian Cells
... of DNA ends in recombination has Adair et ...free DNA ends, such as those generated of homology, suggesting strand invasion and the prim- by the reversal of a replication fork, or when a replica- ing ...
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Erythropoiesis: insights into pathophysiology and treatments in 2017
... DNMT1: DNA-methyl transferase 1; DSB: Double strand break; EPO: Erythropoietin; EPO-R: Erythropoietin receptor; ERFE: Erythroferrone; GvHD: Graft-versus-host disease; HAMP: Hepcidin ...
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Transcription and Double-Strand Breaks Induce Similar Mitotic Recombination Events in Saccharomyces cerevisiae
... of double-strand-break (DSB)-induced recombination and sponta- neous recombination under low- and high-transcription conditions in ...and double mutations, consistent with the actual ...
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The Drosophila spn-D Gene Encodes a RAD51C-Like Protein That Is Required Exclusively During Meiosis
... in double-strand DNA break (DSB) repair enzymes, such as spn-B, activate a meiotic checkpoint leading to dorsal-ventral patterning defects in the egg and an abnormal appearance of the ...
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Capture of DNA Sequences at Double-Strand Breaks in Mammalian Chromosomes
... study double-strand break (DSB)-induced mutations in mammalian chromosomes, we transfected thymidine kinase (tk)-deficient mouse fibroblasts with a DNA substrate containing a ...
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DNA synthesis errors associated with double-strand-break repair.
... In contrast to the spontaneous revertants that were found equally on both chromosomes, it is remarkable that nearly all the revertants were on the chromosome that had th[r] ...
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HOW MANY PROCESSED PSEUDOGENES ARE ACCUMULATED IN A GENE FAMILY?
... This observation suggests that a staggered double-strand break is created at the target site in the DNA, with subsequent replication creating duplicated repeats th[r] ...
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Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti tumor effects of the poly (ADP ribose) polymerase (PARP) inhibitor olaparib in triple negative breast cancer cells
... In summary, findings from the current investigation demonstrated that TNBC cells have different responses to olaparib and SAHA alone or in combination. Combination therapy with selective PARP and HDAC inhibitors may be ...
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DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens
... the DNA damage response (DDR), which controls the lesion detection and DNA ...correct double-strand breaks (DSB), single-strand breaks, mismatches and others, or when the damage ...
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