DNA double-strand breaks
The Role of Long Non Coding RNAs in the Repair of DNA Double Strand Breaks
... DNA double strand breaks (DSBs) are abrasions caused in both strands of the DNA duplex following exposure to both exogenous and endogenous ...words: DNA repair, homologous ...
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Combined Interactions of Plant Homeodomain and Chromodomain Regulate NuA4 Activity at DNA Double-Strand Breaks
... DNA double-strand breaks (DSBs) represent one of the most threatening lesions to the integrity of genomes. Histone modification complexes such as NuA4 and chromatin remod- eling complexes such ...
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Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks
... of DNA double-strand breaks (DSBs) in Saccharomyces cerevisiae implying that MMS somehow induces DSBs in ...causes DNA fragmenta- ...that DNA fragmentation following MMS treat- ...
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Dna Double Strand Breaks Suppress Expression Of The Rag Recombinase: Mechanisms And Consequences
... that DNA double strand breaks (DSBs) induced by a variety of genotoxic agents have a similar effect in suppressing mRNA expression of Rag1 and ...
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H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues
... DNA double-strand breaks (DSBs) are the most dangerous lesions induced by a variety of treatments including ionizing radiation (IR), radiomimetic drugs, and lasers’ ...
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The Homologous Chromosome Is an Effective Template for the Repair of Mitotic DNA Double-Strand Breaks in Drosophila
... of DNA double-strand breaks in mammalian chro- Takata, ...of DNA double-strand break repair have 225–294 in The Genetics and Biology of Drosophila, ...
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DNA Double-Strand Breaks and Telomeres Play Important Roles in Trypanosoma brucei Antigenic Variation
... Plasmodium, DNA recombination-mediated gene conversion is a major pathway for surface antigen switching in these ...of DNA recombination in antigenic variation has been greatly ...that DNA ...
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Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease
... which DNA damage increases with age and is exacerbated by multiple neurological disorders, including Alzheimer ’ s disease ...detect DNA double strand breaks (DSBs), the most severe ...
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The Role of the Ku70 vWA Domain in the Response to DNA Double Strand Breaks
... the double mutant D192A/D195R, ...the DNA repair defect conferred by the Ku70 D192A/D195R ...genomic DNA from Ku70 - / - MEFs expressing Ku70 wild-type (WT), ...
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Molecular Mechanisms of H. pylori Induced DNA Double-Strand Breaks
... and DNA-unwinding activities as well as DNA-binding and DNA end-bridging properties ...pathway, DNA-dependent protein kinase (DNA-PK), which consists of DNA-PK catalytic subunit ...
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Repair of endonuclease and transposon induced DNA double strand breaks by host factors in Arabidopsis
... Germinal utilization of Ds-induced DSB repair pathways is locus-dependent As described above, Ds transposition-induced DSB in transgenic line CSDG21 might be repaired by both NHEJ and HR[r] ...
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DNA Damage-Inducible and RAD52-Independent Repair of DNA Double-Strand Breaks in Saccharomyces cerevisiae
... intensities of individual chromosomal bands that result At low doses, chromosomes were clearly more frag- from the production of bleomycin-induced DSBs. Intact mented in rad52/rad52 cells than in the wild-type cells ...
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Hypersensitivity of ataxia telangiectasia cells to DNA double strand breaks
... ese DNA dam aging agents induce both interc hang es and breakage in chromo somes (see review in C hapter ...ent DNA synthesis did not cause c hrom osom al breakage (Nichols ...in DNA may lead to a ...
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Saccharomyces cerevisiae RAD52 alleles temperature-sensitive for the repair of DNA double-strand breaks.
... Our basic finding, summarized in Figure 7, is that alleles conferring a temperature- sensitive ability to repair double strand DNA breaks do not necessarily confer similar l[r] ...
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Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks
... specific DNA damage and HRR processes following exposure to vosaroxin or ...doxorubicin. DNA in G2 / M phase is shown on the left, with the replication fork advancing during S phase to the ...potential ...
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Induction and rejoining of DNA double-strand breaks in human cells after exposure to ionising radiation: an experimental and modelling approach
... with breaks distributed in the genome uniformly, independently of each ...the DNA fragment size distribution after breaks have been distributed randomly and uniformly in an originally intact molecule ...
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Predictive significance of DNA damage and repair biomarkers in triple-negative breast cancer patients treated with neoadjuvant chemotherapy: An exploratory analysis
... of DNA double-strand breaks (DSBs) ...orchestrates DNA repair ...endogenous DNA damages arising upon oncogene-induced replication stress ...
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Advances in using PARP inhibitors to treat cancer
... radiation-induced DNA damage in patients without known defects in DDR is either possible or ...of DNA damage by the addition of a PARP inhibitor to a topoisomerase I poison has been demonstrated in tumor ...
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Evaluation of DNA Integrity of Cryopreserved Boer Goat (Capra hircus) Sperm Using Comet Assay at Various pH Conditions
... is DNA damage on the sperm which has been identified during the freezing and thawing ...sperm DNA integrity ...differentiate DNA single- and double-strand ...the DNA integrity of ...
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Review on DNA damage, repair and DNA sequencing
... in DNA methylation (hypermethylation and hypomethylation) and histone modification,[11] changes in chromosomal architecture (caused by inappropriate expression of proteins such as HMGA2 or HMGA1)[12] and changes ...
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