DNA metabolism
Studying essential DNA metabolism proteins in Xenopus egg extract
... Furthermore, DNA repair is more complex in higher eukaryotes given the presence of additional essential genes such as BRCA2 and BRCA1, which regulate several aspects of HR (Liu and West, 2002, Thorslund and West, ...
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Overlapping Functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 Nucleases in DNA Metabolism
... MRE11 functions in several aspects of DNA metabolism, including meiotic recombination, double-strand break repair, and telomere maintenance. Although the purified protein exhibits 3⬘ to 5⬘ exonuclease and ...
11
The effect of cytotoxic drugs on the DNA metabolism and proliferation of lymphoblasts
... lymphocyte metabolism It is possible that the spleen lymphocytes were more sensitive to the preparation procedure than the peripheral lymphocytes and were damaged in seme way that was not obviously detectable ...
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DNA METABOLISM DURING PACHYTENE IN RELATION TO CROSSING OVER
... Analyses of DNA synthesis in the diploid hybrid show that normal DNA replication occurs during the premeiotic S phase and during zygotene but only a little synthesis can be detec[r] ...
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Conditional mutations in the yeast DNA primase genes affect different aspects of DNA metabolism and interactions in the DNA polymerase alpha-primase complex.
... Different pril and pri2 conditional mutants of Saccharomyces cereuisiae altered, respectively, in the small (p48) and large (p58) subunits of DNA primase, show an en[r] ...
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Genetic Analysis of Yeast RPA1 Reveals Its Multiple Functions in DNA Metabolism
... HO-cleaved DNA but much less product DNA. Over time the HO-cleaved DNA in the rfa1-t11 mutant disappeared, consistent with the cleaved DNA being degraded and the cells dying as was observed on ...
17
LPP-1 Infection of the Blue-Green Alga Plectonema boryanum
... Viral Deoxyribonucleic Acid Synthesis and Host Deoxyribonucleic Acid Breakdown Received for publication 1 September 1970 Host and viral deoxyribonucleic acid DNA metabolism in LPP-1-infe[r] ...
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THE EFFECTS OF MUTAGEN-SENSITIVE MUTANTS OF DROSOPHILA MELANOGASTER IN NONMUTAGENIZED CELLS
... Further evidence sug- gesting an overlap in the control of these two aspects of DNA metabolism has come from the finding that mutants at the mz&-201 and mus-102 l[r] ...
15
In vivo effects of recBC DNase, exonuclease I, and DNA polymerases of Escherichia coli on the infectivity of native and single-stranded DNA of bacteriophage T7.
... WACKERNAGEL* Abteilung Biologie, Lehrstuhl Biologie der Mikroorganismen, Ruhr-Universitat, 4630 Bochum, Germany The effect of several enzymes of the DNA metabolism of Escherichia coli on[r] ...
7
Ligase-Defective Bacteriophage T4 I. Effects on Mutation Rates
... An genes affecting DNA metabolism have recently rII+ revertant of a gene 30-rII double mutant been reported 4 to enhance the reversion rates should therefore be at a selective disadvanta[r] ...
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Of Mouse And Methyl: An Investigation Of Methyl Donors, Methylation And Methyltransferases In The Pfc
... In the current study, we found that perinatal HF diet can alter nuclear DNMT activity at 8 weeks of age. It should be recognized that the current assay utilized measured activity off all present DNMTs. Methods to ...
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Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia
... studied, and it continues to evolve. Advances in understanding of chromatin structure, histone modification, transcriptional activity, DNA methylation gene mutation, have lead to an integrated approach to the role ...
10
Genetic Analyses of Schizosaccharomyces pombe dna2+ Reveal That Dna2 Plays an Essential Role in Okazaki Fragment Metabolism
... The dna2 ⴙ gene product is essential, but not required for initiation and elongation stages of DNA replication during germination of spores: We investigated whether S. pombe dna2 ⫹ is essential for cell viability ...
13
MYC driven accumulation of 2 hydroxyglutarate is associated with breast cancer prognosis
... 1-carbon metabolism and altering the availability of the universal methyl donor SAM and the methyltransferase inhibitor ...of DNA hypermethylation at loci that encode these ...
16
Reconstruction of a Global Transcriptional Regulatory Network for Control of Lipid Metabolism in Yeast by Using Chromatin Immunoprecipitation with Lambda Exonuclease Digestion
... the DNA binding of five Saccharomyces cerevisiae transcription factors involved in lipid metabolism, Ino2, Ino4, Hap1, Oaf1, and Pip2, in response to four different environmental conditions in chemostat ...
15
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone
... glutamine metabolism in mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) PDA sensitizes cell lines and tumors to ß-lapachone (ß-lap, clinical form ...glutamine metabolism in mutant KRAS, NQO1 ...
12
Preceding exercise and postprandial hypertriglyceridemia: effects on lymphocyte cell DNA damage and vascular inflammation
... postprandial DNA damage, further work is required to explore the signifi- cance, if any, of such ...radical-induced DNA damage can have deleterious con- sequences to normal cell function and prompts a state ...
12
Mmf1p Couples Amino Acid Metabolism to Mitochondrial DNA Maintenance in Saccharomyces cerevisiae
... cellular metabolism, 2AA is generated by pyridoxal 5=-phosphate (PLP)-dependent ␣ ,  -eliminase enzymes as an intermediate in the conversion of amino acids to pyruvate (3, 4, ...
13
Sirtuins in metabolism, DNA repair and cancer
... In addition to its critical roles in glucose metabolism, SIRT1 is also convinced to regulate lipid homeostasis. During fasting, SIRT1 deacetylates and destabilizes sterol regulatory element binding protein 1 ...
14
Computational Modelling Folate Metabolism and DNA Methylation: Implications for Understanding Health and Ageing
... folate metabolism tend to have rate laws where the velocity of a reaction assumes mass action kinetics or is based on an enzyme kinetic law ...folate metabolism, where the parameters were derived from a ...
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