DNA methylation ,cancer
Integrated analysis of genome-wide DNA methylation and gene expression profiles identifies potential novel biomarkers of rectal cancer
... DNA methylation was regarded as the promising biomarker for rectal cancer ...optimal methylation biomarkers with ideal diagnostic performance for rectal cancer are still ...rectal ...
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The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study
... between DNA methylation at the ALOXE3 gene and 8-isoprostane concentrations might reflect the fact that both depend on the level of OS in ...of DNA methylation at the ALOXE3 gene and lung and ...
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Vitamin D, DNA methylation, and breast cancer
... breast cancer (852 cases, 1026 from subcohort, including 41 additional cases): ratio of hazard ratios and 95% confidence ...and methylation on the 5-year risk of postmenopausal breast cancer (852 ...
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DNA Methylation in Colorectal Cancer: A brief Review
... factors, DNA methylation is one of the most important factors that is thought to occur during the early stages of oncogenic ...genome DNA methylation which brings about heritable and ...
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Original Article Semaphorin-3F functions as a tumor suppressor in colorectal cancer due to regulation by DNA methylation
... unclear. DNA methylation plays an important role in ...island methylation of tumor suppressor gene resulted in inactivation of the gene transcription has become an important part of cancer ...
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DNA methylation changes following DNA damage in prostate cancer cells
... While DNA methylation profiles in prostate cancer cells with divergent response to RT were stable on a genome-wide scale following a single dose of RT, a small subset of genes displayed altered CpG ...
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DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer
... to DNA double-strand break repair [21, 22] might highlight this protein as an interesting target for potential cancer ther- ...targeting DNA double-strand break ...by methylation loss has gene ...
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Downregulation and DNA methylation of ECRG4 in gastric cancer
... Esophageal cancer-related gene 4 (ECRG4) is a novel candidate tumor suppressor ...gastric cancer and high- lighted the role of DNA hypermethylation at the promoter in silencing the ECRG4 ...gastric ...
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DNA methylation signatures for breast cancer classification and prognosis
... bisulfiteconverted DNA. These studies provided the initial proof of principle that DNA methy la tion patterns are different between tissue types and between tumors and normal surrounding ...the DNA ...
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DNA methylation epigenotypes in breast cancer molecular subtypes
... profiling, DNA methyla- tion profiling is considered to allow the molecular classi- fication of human malignancies and monitoring cancer progression based on a tumor-specific methylation sig- nature ...
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Ovarian cancer detection by DNA methylation in cervical scrapings
... Ovarian Cancer Study (AOCS)–tissue dataset was analyzed using the Human- Methylation450 BeadChip (Illumina, San Diego, CA, USA) and deposited in the NCBI’s Gene Expression Omnibus (GEO) with accession number ...
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Pan-cancer patterns of DNA methylation
... of DNA methylation DNA methylation usually occurs at cytosine-guanine (CpG) dinucleotides, where DNA methyltransferases (DNMTs) catalyze the transfer of a methyl group to pos- ition 5 ...
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DNA methylation profile of the DKK2 gene as a biomarker in patients with colorectal cancer
... the methylation of the DKK2 gene is a good indicator for tumor detection, the next step would be the presence of this marker in a biological sample with the objective of assisting in the early detection of tumoral ...
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Role of DNA methylation in head and neck cancer
... global methylation profiling, and detailed analysis of downstream DNA repair genes regulated by promoter methylation may provide new insight into the ...differential methylation are RASSF1A, ...
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Epimutations, Inheritance and Causes of Aberrant DNA Methylation in Cancer
... to methylation based on CpG island size, GC content, CpG frequency, chromosomal location or promoter ...the methylation state of several CpG islands in cells over-expressing ...to methylation, but a ...
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Deciphering DNA methylation signatures of pancreatic cancer and pancreatitis
... increased DNA methylation levels in all PT specimens ( n = 56), com- pared to the normal pancreas (n = ...scoring DNA methylation in more than one gene was highly predictive of PT: nine of 11 ...
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The SMART App: an interactive web application for comprehensive DNA methylation analysis and visualization
... [17], DNA methylation (Human- Methylation450k; Primary Solid Tumor and Solid Nor- mal Tissue), somatic mutation (Gene-level non-silent mutation), copy number variation (Gene-level GISTIC2 thresholded), ...
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Altered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer
... the DNA sequence, and involves DNA methylation, histone acetylation and chromatin remodeling ...[20]. DNA methylation is important in various biological processes, such as genomic ...
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Comparison of methylation patterns of E6 gene promoter region in the low-risk and high-risk human papillomavirus
... ing methylation of genome involved in different as- pects is ...cervical cancer progression ...in DNA methylation is not fully under- ...
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<p>Increased expression of TMED2 is an unfavorable prognostic factor in patients with breast cancer</p>
... breast cancer compared to the normal mammary tissues (Figure ...breast cancer sample, we analyzed the DNA copy number and DNA methylation level of breast cancer and normal breast ...
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