DNA mismatch repair defects
DNA repair defects and implications for immunotherapy
... When DNA repair fails, this damage can lead to carcinogenesis and tumor genomic ...germline defects in DNA repair ...these defects may also portend particular vulnerabilities of ...
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Defective mismatch repair and DNA damage sensing in human cells
... of DNA repair to cellular survival following DNA ...the repair of DNA carboxymethylation damage, a potential endogenous form of DNA damage, using a panel of cell lines with ...
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Mismatch repair gene defects in sporadic colorectal cancer enhance immune surveillance
... This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and ...
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Two main mutational processes operate in the absence of DNA mismatch repair
... 2.3. Two mutational signatures derived from classified MMRd tumours We sought to redefine MMRd-associated SNV signatures using a pooled TCGA mutation dataset from whole exome sequencing of 146 samples of colorectal, ...
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The Role of DNA Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells
... that mismatch repair (MMR) mediates the cytotoxic effects of DNA damaging agents by exerting a futile repair pathway which leads to double strand breaks ...to DNA alkylation is reduced ...
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DNA mismatch repair gene MLH1 induces apoptosis in prostate cancer cells
... [10]. Defects in MLH1 have been documented in various cultured prostate cell ...reduced DNA repair activity as compared to the MMR proficient Hela ...
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DNA Polymerases as Potential Therapeutic Targets for Cancers Deficient in the DNA Mismatch Repair Proteins MSH2 or MLH1
... gene defects (Hartwell et ...and DNA polymerases also exist in human tumor cells and can be exploited to specifically target cells carrying these underlying gene ...oxidized DNA lesions may, in part ...
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A Role for DNA Mismatch Repair Protein Msh2 in Error-Prone Double-Strand-Break Repair in Mammalian Chromosomes
... the repair of double-strand DNA breaks. Mutat. for human DNA mismatch-repair gene ...Deficient DNA mismatch repair: a common Yang, Q, ...The mismatch ...
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Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans
... DISCUSSION Transmission of an organism’s genetic material through mitosis is extremely accu- rate due to the activity of a number of systems that detect the introduction of incorrect nucleotides during DNA ...
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Prognostic impact of mismatch repair genes germline defects in colorectal cancer patients: are all mutations equal?
... Multiplex ligation-dependent probe amplification (MLPA) analysis Cases who tested negative for the mutational analyses were investigated for the presence of genomic rearrangements, including the deletion or duplication ...
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Role of DNA Mismatch Repair and Double-Strand Break Repair in Genome Stability and Antifungal Drug Resistance in Candida albicans
... when DNA repair pathways are eliminated, we constructed yeast strains bearing deletions in six genes involved in mismatch repair (MSH2 and PMS1) or double-strand break repair (MRE11, ...
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Maternal Effect for DNA Mismatch Repair in the Mouse
... was observed. To determine the consequences of maternal DMR deficiency on genetic stability, we analyzed F 1 progeny from Pms2 ⫺ / ⫺ female mice mated with wild-type males. Our analysis indicates that MSI in the female ...
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Evolutionary consequences of DNA mismatch inhibited repair opportunity.
... T h e natural selection attributable to the interaction between mismatch in- hibited repair opportunities associated with nucleotide sequence heterozygosity and increased le[r] ...
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Frequent mismatch-repair defects link prostate cancer to Lynch syndrome
... and mismatch-repair status, and the cumulative risk of prostate cancer was ...respective mismatch repair protein in 69 % of the tumors, though a MSI-high phenotype was restricted to 13 % of ...
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Mismatch Repair Mutants in Yeast Are Not Defective in Transcription-Coupled DNA Repair of UV-Induced DNA Damage
... coli mis- match repair mutants, we found that mutations in yeast mismatch repair genes had no discernable effect upon either transcription-coupled repair or global nucleotide [r] ...
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Endonuclease-independent DNA Mismatch Repair Processes on the Lagging Strand
... MMR repair efficiency by taking into account the oligo transformation efficiency, which is determined by the extracted fraction of the population with the control mutation at the control mismatch site, and ...
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Endonuclease activities of MutLα and its homologs in DNA mismatch repair.
... of DNA onto the structural model of the ...the DNA within a distance from each other that allows the carboxylate side chain of the aspartate residue in the first position of the motif to activate catalysis ...
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Studying The Role Of DNA Mismatch Repair In Brain Cancer Malignancy
... the DNA. During imprecise repair of the DNA insertion and deletions mutations are introduced [7] ...the DNA to be cut at the target locations by the Cas protein, and the two extreme ends of ...
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Mismatch Repair Processing of DNA Damage Causes Replication Stress
... that repair across Me G lesions might interrupt replication fork progression, uncoupling the DNA polymerase from the replicative helicase resulting in ssDNA stretches (Byun, Pacek et ...cellular DNA ...
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Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer
... with mismatch repair defects in prostate cancer Daniel Nava Rodrigues, 1,2 Pasquale Rescigno, 1,2,3 David Liu, 4,5 Wei Yuan, 1 Suzanne Carreira, 1 Maryou ...
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