DNA single strand breaks
The generation of DNA single-strand breaks during the reduction of chromate by ascorbic acid and/or glutathione in vitro.
... With relatively high amounts of chromate (500 PM) however, the combina- tion of AsA and GSH exhibited a slightly protective influence on the generation of strand breaks; the cleavage obs[r] ...
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Increased single strand breaks in DNA of lymphocytes from diabetic subjects
... of DNA single strand ...lymphocyte DNA when compared to controls (P less than ...in DNA lesions, whose impact on long-term complications deserves to be ...
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Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
... both DNA single- strand breaks (SSBs) and DNA double-strand breaks (DSBs); lesions that can trigger neurodegeneration and neurodevelopmental dysfunction, ...the DNA ...
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A. Recombination initiated by single-strand breaks
... The Strange world of Bionanomachines Very remarkably, many of nanomachines will always perform their functions automatically, after they are isolated and purified, provided the environment is not too hard. They must not ...
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Effects of DNA Double-Strand and Single-Strand Breaks on Intrachromosomal Recombination Events in Cell-Cycle-Arrested Yeast Cells
... In DNA DSBs may be involved in these DEL recombina- strain AGY 26A (w/o M13ori) on galactose only a nonsig- tion events ( Galli and Schiestl ...on DNA damage, repair and recombination pro- galactose, did ...
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Regulation of telomere addition at DNA double-strand breaks
... of DNA damage response factors in the absence of checkpoint activation or end fusion) is reminiscent of observations reported recently in which many different mammalian cell lines, usually those possessing ...
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DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II
... Spain DNA double strand breaks (DSBs) are the most cytotoxic lesions of those occurring in the DNA and can lead to cell death or result in genome mutagenesis and chromosomal ...survival, ...
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Genome‐wide detection of induced DNA double strand breaks
... the histone modifications at radiation‐induced DSB sites detected in all three passages were analyzed. Neither the position of the DSB sites around the transcription start site nor a specific histone modification was ...
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Capture of DNA Sequences at Double-Strand Breaks in Mammalian Chromosomes
... positioned 1.5 kb apart are indicated. These primers were Cell lines that, on the basis of Southern blotting analysis, used to amplify tk sequences from cells that had undergone appeared to contain a single ...
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Hypersensitivity of ataxia telangiectasia cells to DNA double strand breaks
... of DNA lesions (Taylor ...two single strand breaks) induced by BamH I since t he staggered ends m ay facilitate the linking up of broken strand of DNA (Costa and Bryant ...
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Efficient Repair of DNA Breaks in Drosophila: Evidence for Single-Strand Annealing and Competition With Other Repair Pathways
... Although DNA breaks are eventually resealed by all Breaks induced by mobilization of P-element transpo- of these pathways, some restore the original sequence sons in the developing germ line of ...
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Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
... The DIvA system allows not only precise knowledge of the position of all AsiSI-induced DSBs but also their exact number within each cell. This permits comparison of the number of do- mains linearly depicted on the genome ...
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Accumulation of Werner protein at DNA double-strand breaks in human cells
... of DNA helicases with an exonuclease ...several DNA repair processes, but the actual functions of WRN in living cells remain ...of DNA damage produced locally in the nucleus of human ...
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Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease
... Immunostained cultures were imaged with a high-con- tent ArrayScan system (Thermo Fisher Scientific) and a 40x objective, yielding 1024 × 1024 pixels per image. For each well, 15–20 images were obtained from different ...
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Coupling DNA Damage and Repair: an Essential Safeguard during Programmed DNA Double- Strand Breaks?
... of coupling prDSB formation and repair within a single protein during programmed meiotic 308 recombination. 313[r] ...
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Hypoxia Sensitive Metal β-Ketoiminate Complexes Showing Induced Single Strand DNA Breaks and Cancer Cell Death by Apoptosis
... cellular DNA was also assessed. The complexes failed to induce double strand DNA break or DNA crosslinking but induced significant levels of single DNA strand ...
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Hypoxia-Sensitive Metal β-Ketoiminate Complexes Showing Induced Single Strand DNA Breaks and Cancer Cell Death by Apoptosis
... cellular DNA was also assessed. The complexes failed to induce double strand DNA break or DNA crosslinking but induced significant levels of single DNA strand ...
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Hypoxia-Sensitive Metal β-Ketoiminate Complexes Showing Induced Single Strand DNA Breaks and Cancer Cell Death by Apoptosis
... Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a ...
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November 1972 KFK In Vitro Repair 01 Single-strand Breaks in l'-irradiated DNA by Polynucleotide. A. Jacobs, A. Bopp, U.
... With increasing concentrations of polynucleotidc ligase up to 100 per cent of the single-strand breaks of the 3'OH-5'P DNA can be joined, whereas in irradiated DNA up to 40 per cent of a[r] ...
The Homologous Chromosome Is an Effective Template for the Repair of Mitotic DNA Double-Strand Breaks in Drosophila
... a single DSB at the element in the presence of transposase, presumably either terminus would be sufficient to initiate the SSA as the result of GC templated from the homolog that ...
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