DNA Viruses
CDK9 inhibitor FIT 039 prevents replication of multiple DNA viruses
... a potential public health risk. Here, we explored the use of compounds that inhibit or interfere with the action of essential host factors to prevent virus replication. In particular, we focused on the cyclin-dependent ...
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A Hypothesis for DNA Viruses as the Origin of Eukaryotic Replication Proteins
... DNA viruses, however, also possess a full set of independent DNA replication and repair proteins that include members of family A and B DNA Pols ...T4 DNA Pol was to DNA Pols ...
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A broadly applicable method to characterize large DNA viruses and adenoviruses based on the DNA polymerase gene
... culturable viruses (in estab- lished cell lines or readily available primary ...to viruses that are associated with an important ...of viruses are either unculturable, difficult to culture or are not ...
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DNA from Dust: Comparative Genomics of Large DNA Viruses in Field Surveillance Samples
... These viruses were collected from vaccinated hosts that acquired naturally circulating field strains of MDV-1, in the absence of a disease ...all DNA identity, and despite strong evidence of purifying ...
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Evolution of DNA ligases of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes: a case of hidden complexity
... large DNA viruses of eukaryotes (NCLDV), namely, Pox- viridae, Asfarviridae, Iridoviridae, and Phycodnaviridae, share a set of conserved genes with functions implicated in replication, transcription and ...
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Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses
... of viruses comprises the negative- strand RNA ...the viruses repli- cated efficiently, as is demonstrated by the synthesis of viral nucleocapsid proteins ...RNA viruses (exem- plified by SARS-CoV) ...
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Hidden evolutionary complexity of Nucleo Cytoplasmic Large DNA viruses of eukaryotes
... the DNA polymerase (DNAP) and the primase-helicase, are central and indispensable to replication and are shared by all viruses of this class (it has been claimed that the primase-helicase was missing in ...
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Host Noncoding Retrotransposons Induced by DNA Viruses: a SINE of Infection?
... how DNA virus infection may lead to their induction, and describe how novel gene regulatory and immune-related functions of these ncRNAs may impact the viral life ...
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Identification of an l-Rhamnose Synthetic Pathway in Two Nucleocytoplasmic Large DNA Viruses
... most viruses, which use the host ER/Golgi system for glycosylation of their surface proteins and whose glycan structure and composition are completely dependent on their host cells ...
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A New Family of DNA Viruses Causing Disease in Crustaceans from Diverse Aquatic Biomes
... crustacean viruses is similar to that of ...large DNA viruses (NCLDVs), these viruses complete their morphogenesis in the host cell nu- cleus rather than in the ...crustacean viruses ...
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Metagenomic Next Generation Sequencing for Identification and Quantitation of Transplant Related DNA Viruses
... with DNA viruses are frequent causes of morbidity and mor- tality in transplant ...double-stranded DNA (dsDNA) viruses (adenovirus [ADV], BK virus [BKV], cytomegalovirus [CMV], Epstein-Barr ...
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New DNA Viruses Identified in Patients with Acute Viral Infection Syndrome
... undescribed DNA viruses were also detected, a parvovirus and two viruses related to TT virus ...TTV-like viruses highly divergent from both the TTV and TTV-like minivirus ...human ...
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Metagenomic analysis of double-stranded DNA viruses in healthy adults
... of viruses was detected in healthy ...human DNA viruses (Figure 2A). The double-stranded DNA (dsDNA) viruses included members of the virus families Herpesviridae , Papillomaviridae , ...
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Widely Conserved Recombination Patterns among Single-Stranded DNA Viruses
... single-stranded DNA (ssDNA) virus ...against viruses expressing recombinant proteins is a major determinant of nonrandom recombination breakpoint distributions observable in most ssDNA virus ...
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Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?
... As obligate intracellular parasites, viruses have evolved a myriad of strategies to manipulate the host cell environment to one that is conducive for virus replication. Research over recent decades has identified ...
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Common Origin of Four Diverse Families of Large Eukaryotic DNA Viruses
... all viruses within this clade are obvious candidates for ancestral origin but, additionally, other genes identified as synapomorphies of the NCLDV clade are also, according to the parsimony principle, likely to ...
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The RNA Epitranscriptome of DNA Viruses
... T he flow of information orchestrated in myriad molecular events affords the cell with opportunities to maintain a steady state in response to diverse intracellular and extracellular signals. As an intermediate molecule ...
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High Variety of Known and New RNA and DNA Viruses of Diverse Origins in Untreated Sewage
... ss- DNA genomes showed ⬎ 19% Rep protein identities to Rep pro- teins in the Geminiviridae versus ⬍15% identities to those in the Circoviridae and Nanoviridae (see Table S12 in the supplemental ...these ...
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Adenosine triphosphatases of thermophilic archaeal double-stranded DNA viruses
... viral DNA delivery into the host ...viral DNA injection into the host and its subsequent release is derived from studies on tailed bac- teriophages, although a few archaeal viral studies have been performed ...
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DNA viruses associated with diseases of marine and anadromous fish
... Flfigel et al... Reno et al.[r] ...
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