Dopamine D2
![Synthesis and evaluation in rats of homologous series of [18F]-labeled dopamine D2/3 receptor agonists based on the 2-aminomethylchroman scaffold as potential PET tracers](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
Synthesis and evaluation in rats of homologous series of [18F]-labeled dopamine D2/3 receptor agonists based on the 2-aminomethylchroman scaffold as potential PET tracers
... 23. Mewshaw RE, Kavanagh J, Stack G, Marquis KL, Shi X, Kagan MZ, et al. New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity ...
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THE INHIBITORY EFFECT OF ASCORBIC ACID ON APOMORPHINE-INDUCED LICKING BEHAVIOR IS MEDIATED BY DOPAMINE D2 RECEPTOR MECHANISMS IN RAT
... in dopamine receptor function has been ...mixed dopamine D1/D2 receptor agonist; apomorphine in ...the dopamine D1 receptor antagonist SCH 23390 or the dopamine D2 receptor ...
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Effects of Ovariectomy and 17β Estradiol Replacement on Dopamine D2 Receptors in Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight
... of dopamine D2 receptors in the regula- tion of food intake and body ...that D2 receptor KO mice showed reduced food intake and body weight along with an increased basal energy expenditure level ...
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Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?
... with dopamine release mea- sured indirectly by displacement of radio ligands of dopamine D2 receptors in this brain area 21 ...that dopamine-dependent encoding of reward-anticipatory Table 1 ...
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Agonist signalling properties of radiotracers used for imaging of dopamine D2/3 receptors
... beta-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic ...of dopamine D2/3 receptors in their high-affinity ...
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The expression profile of Dopamine D2 receptor, MGMT and VEGF in different histological subtypes of pituitary adenomas: a study of 197 cases and indications for the medical therapy
... Currently, first-line clinical medication for PAs gener- ally consists of dopamine agonists (DAs), somatostatin analogs (SSAs) or combinations [4]. Recently, some rou- tine chemotherapeutics such as Temozolomide ...
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Relationship between calorie intake, physical activity, and dopamine D2 receptor Taq1A gene polymorphism in normal-weight, overweight, and obese students of the faculty of medicine of university of Sumatera Utara
... and dopamine D2 receptor Taq1A (DRD2 Taq1A) gene polymorphism in normal- weight, overweight, and obese students of the Faculty of Medicine of University of Sumatera, ...
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Role of dopamine D2 receptors in ischemia/reperfusion induced apoptosis of cultured neonatal rat cardiomyocytes
... Here we investigated the effects of both dopamine D2 receptors agonist (bromocriptine) and antagonist (haloperidol) on apoptosis of cultured neonatal rat ventricular myocytes induced by [r] ...
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Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia
... GFP (Fig. 1 e-j, Additional file 2: Figure S2). Significant transgene expression was observed in the soma (D2R s Fig. 1 Experimental design and model validation. a Experimental timeline showing LID-inducing L-DOPA ...
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Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
... dopamine system and the tuberoinfundibular pathway, respec- tively 1–6 . Many “typical” or first-generation antipsychotics (FGAs) exhibit a relatively narrow therapeutic window with respect to these “on-target” ...
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Modulatory Effects of Dopamine D2 Receptors on Spreading Depression in Rat Somatosensory Neocortex
... 2 dopamine receptor agonist quinpirole (10, 20, 50, 100, 200 micro mol/l; n: 6 for each concentration) was inves- tigated on KCl-induced negative depolarization shifts in the neocortical ...
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Dopamine D2 receptor functional selectivity as a mechanism of atypical antipsychotic drug action
... efficacy and side effect profile. Clinicians observed that the typical APDs failed to effectively reduce positive symptoms in 30-60% of diagnosed patients, while having no effect on negative symptoms and cognitive ...
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Dopamine D2 receptors in the pathophysiology of insulin resistance
... Hoewel hoog vet voeding over het algemeen overgewicht en insuline resistentie veroorzaakt in knaagdieren, kunnen individuele dieren van eenzelfde stam toch heel verschillend reageren. Aan de hand van de gewichtstoename ...
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Knocking Down the DRD2 by shRNA Expressing Plasmids in the Nucleus Accumbens Prevented the Disrupting Effect of Apomorphine on Prepulse Inhibition in Rat
... by dopamine agonists is not ...against dopamine D2 receptor genes (DRD2) in the nucleus accumbens, here, we studied the effect of apomorphine on PPI in D2 down-regulated ...
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Thesis
... the dopamine D2 receptor (D2R), the primary target for antipsychotic drugs, to 17 human ...with D2- selective drug, quinpirole, and the D2R endogenous ligand, ...that dopamine and quinpirole ...
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BIOCHEMICAL, NEUROCHEMICAL AND BEHAVIOURAL RESPONSES FOLLOWING ADMINISTRATION OF 6-FLUORO-3-(PIPERIDIN-4-YL) BENZO[D] ISOXAZOLE DERIVATIVES AND ANTIPSYCHOTIC DRUGS IN MICE
... with dopamine D2 receptor with lesser affinity and serotonin 5HT2a receptors with comparably higher affinity as possible drug molecules with fewer propensities to cause ...
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Development of a peptide targeting dopamine transporter to improve ADHD-like deficits
... between dopamine D2 recep- tor (D2R) and dopamine transporter (DAT) provides a new way to modulate the activities of DAT and dopa- mine ...extracellular dopamine level ...
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Contribution of BDNF and DRD2 genetic polymorphisms to continued opioid use in patients receiving methadone treatment for opioid use disorder: an observational study
... the dopamine receptor D2 (DRD2) gene plays a major role in opioid use disorders because of its involvement in the reward–dependence pathway ...of dopamine D2 receptors, which are involved in ...
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<p>Once-Monthly Subcutaneously Administered Risperidone in the Treatment of Schizophrenia: Patient Considerations</p>
... Population pharmacokinetics and prediction of dopamine D2 receptor occupancy after multiple doses of RBP-7000, a new sustained-release formulation of risperidone, in schizophrenia patien[r] ...
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Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance
... of dopamine, such as the control of motor behavior [7] or dopamine-mediated reward pro- cesses in nucleus accumbens [8], a concomitant stimula- tion of D1 and D2 receptors is required, a phenomenon ...
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