Dopamine transporter
Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
... While the current study has strengths, including a restricted age range and the assessment of executive func- tion using multiple indices while children were not taking psychostimulant medication, its results should be ...
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Development of High Resolution Melting (HRM) Methods to Detect Dopamine Transporter (DAT) Gene (SLC6A3) (rs27072) Polymorphisms in Human
... employs dsDNA intercalating dye and its analysis is based on the form of thermodynamics difference between DNA fragments. HRM methods also are rapid, simple and efficient technique since the PCR amplification and HRM ...
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The Role of Functional Dopamine Transporter SPECT Imaging in Parkinsonian Syndromes, Part 2
... he dopamine transporter is a sodium chloride– dependent transmembrane protein localized to the presynaptic nigro- striatal cell ...of dopamine transporters (DaT) with specific tracers gives a guide ...
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Dopamine transporter changes after unilateral deep brain stimulation in progressive Parkinson's disease: a case report
... reducing dopamine transporter ...striatal dopamine transporter binding during one year of follow-up after unilateral DBS at the subthalamic ...disease, dopamine transporter, ...
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Advanced brain dopamine transporter imaging in mice using small-animal SPECT/CT
... striatal dopamine transporter function in rats by in vivo beta-[123I]-CIT pinhole ...of dopamine and serotonin transporters with [123I]beta-CIT: pharmacological characterization of brain uptake in ...
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Replication of an Association of a Promoter Polymorphism of the Dopamine Transporter Gene and Attention Deficit Hyperactivity Disorder
... The dopamine transporter is the main site of action of stimulant medications, which provide a marked and rapid reduction in the level of ADHD ...the dopamine transporter gene ...
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Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor
... of dopamine neuron number and optical density measurement of dopamine fiber loss were carried out at 1 week after treatment, using immunostaining for dopamine transporter (DAT) and tyrosine ...
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Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder
... 19. Hebebrand J, Dempfle A, Saar K, Thiele H, Herpertz-Dahlmann B, Linder M, Kiefl H, Remschmidt H, Hemminger U, Warnke A, Knölker U, Heiser P, Friedel S, Hinney A, Schäfer H, Nürnberg P, Konrad K: A genome-wide scan for ...
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Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption
... Introduction: Regulated neurotransmitter actions in the mammalian central nervous system determine brain function and control peripheral organs and behavior. Although drug-seeking behaviors, including alcohol ...
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Homozygous loss of function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism dystonia
... Genetic variants of the SLC6A3 gene that encodes the human dopamine transporter (DAT) have been linked to a variety of neuropsychiatric disorders, particularly attention deficit hyperactivity disorder. In ...
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Dopamine transporter 1 (DAT1) rs40184 single nucleotide polymorphism is not associated with the Malaysian major depressive disorder subjects
... the dopamine transporter in the aetiology of the disorder, future studies must be conducted to screen for the role of other SNPs in the gene using larger sample size both at the individual and haplotype ...
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Association between Dopamine Transporter Gene (DAT1) Polymorphisms and Eating Disorders with Binge Eating Behavior
... Objectives: Dyshomeostasis of the dopaminergic system is implicated in the pathophysiology of eating disorders (EDs). We have previously reported an association between 3'-UTR VNTR (three prime untranslated region ...
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Dopamine transporter imaging with [18F]FE-PE2I PET and [123I]FP-CIT SPECT—a clinical comparison
... Dopamine transporter (DAT) imaging is a key support- ing diagnostic examination to distinguish patients with idiopathic parkinsonism (PS) (e.g., Parkinson’s disease, multisystem atrophy, progressive ...
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Dopamine D3 receptor and GSK3β signaling mediate deficits in novel object recognition memory within dopamine transporter knockdown mice
... Keywords: Novel object recognition (NOR), Dopamine, Dopamine D3 receptor, Glycogen synthase kinase 3 (GSK3), Medial prefrontal cortex (mPFC), Dopamine transporter knockdown (DAT-KD).. © [r] ...
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The presence of both serotonin 1A receptor (HTR1A) and dopamine transporter (DAT1) gene variants increase the risk of borderline personality disorder
... genes (Torgersen, 2000; Torgersen et al., 2000; Joyce et al., 2006, 2009; Distel et al., 2008a) including genes relating to serotonergic and dopaminergic neurotransmission. The dopaminergic system is involved in ...
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The diagnostic accuracy of dopamine transporter SPECT imaging to detect nigrostriatal cell loss in patients with Parkinson’s disease or clinically uncertain parkinsonism: a systematic review
... standard. Dopamine transporter single-photon emission computed tomography (DAT SPECT) imaging might have the potential (high diagnostic accuracy and practical to use) to act as reference standard in ...
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No difference in striatal dopamine transporter availability between active smokers, ex-smokers and non-smokers using [123I]FP-CIT (DaTSCAN) and SPECT
... The dopamine transporter (DAT) provides the primary mechanism through which dopamine is cleared from the extracellular fluid after its release from the presynaptic ...of dopamine by DAT) and ...
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Missense dopamine transporter mutations associate with adult parkinsonism and ADHD
... sodium-coupled dopamine transporter (DAT) controls dopamine homeostasis, but its contribution to disease remains poorly ...reduced dopamine uptake capacity but preserved membrane targeting, ...
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Lack of Association between Polymorphisms of the Dopamine Receptor D4 and Dopamine Transporter Genes and Personality Traits in a Korean Population
... the dopamine neurotransmitter ...between dopamine receptor D4 (DRD4) exon III and dopamine transporter (DAT1) polymorphisms and personality ...
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Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model
... Anomalous dopamine release associated with a human dopamine transporter coding ...of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux ...
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