dopaminergic neuron
The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation
... the idea that Uncx4.1 is primarily acting during a short, critical window of differentiation of mDA neurons. Accordingly, the numbers of mDA neurons is unaffected at adult stages when Uncx4.1 was conditionally inacti- ...
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Neuroprotective Effects of Tetramethylpyrazine against Dopaminergic Neuron Injury in a Rat Model of Parkinson's Disease Induced by MPTP
... against dopaminergic neuron injury in a rat model of Park- inson's disease induced by MPTP and to elucidate probable molecular ...MPTP-induced dopaminergic neurons damage, reflected by improvement of ...
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Silencing of the Pink1 Gene Expression by Conditional RNAi Does Not Induce Dopaminergic Neuron Death in Mice
... Figure 3. Silencing of the PINK1 gene expression does not cause dopaminergic neuron death. (A) The striatal contents of the neurotrans- mitter dopamine (DA) and its me- tabolites DOPAC and HVA were measured ...
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Suppressed microRNA-96 inhibits iNOS expression and dopaminergic neuron apoptosis through inactivating the MAPK signaling pathway by targeting CACNG5 in mice with Parkinson’s disease
... be determined (Guan et al. 2016). There ’ s evidence dem- onstrating that CACNG5 is expressed in brain tissues, and the mutation of CACNG5 is associated with schizophrenia (Guan et al. 2016), and CACNG5 is also involved ...
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Dual role for Drosophila lethal of scute in CNS midline precursor formation and dopaminergic neuron and motoneuron cell fate
... of dopaminergic neurons, there has been intensive analysis of the regulatory factors that control their development in vertebrates and ...in dopaminergic neuron differentiation conserved between ...
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Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration
... the dopaminergic neuron degeneration that underlies Parkinson’s disease ...accelerated dopaminergic cell and axonal loss compared with parkin-deficient animals, which showed none, and RET-deficient ...
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Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson’s disease
... Parkinson’s disease (PD), clinically manifested with resting tremor, dyskinesia/akinesia, posture instability, rigidity, and other motor symptoms [1], results from a preferential dysfunction/loss of the substantia nigra ...
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ANALYZING THE EFFECT OF BETA BOSWELLIC ACID (BBA) TO DOPAMINERGIC NEURON DIFFERENTIATION OF TRANSGENE EXPRESSING MOUSE EMBRYONIC STEM CELLS
... produce dopaminergic cells an the other hand it has been attempted to treat the Parkinson's disease through culturing the embryonic stem cells expressing Nurr1 / GPX1 the result of which is discussed as ...
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Transcriptional control of midbrain dopaminergic neuron development
... DA neuron markers and the generation of ectopic DA neurons (Kele et ...mDA neuron development will come from the identification of its transcriptional targets and cofactors in both mDA progenitors and ...
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The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities
... In contrast to the extensive analysis of R1441G, R1441C, and G2019S TG mice, no LRRK2 TG rodent model with the I2020T mutation has ever been reported. G2019S and I2020T, despite being mutations affecting neighboring ...
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Involvement of dopamine D2 receptor in the diurnal changes of tuberoinfundibular dopaminergic neuron activity and prolactin secretion in female rats
... technical limitations, the time-dependent changes in TIDA neuron activity can only be determined using dif- ferent groups of rats sacrificed at different time points, but not in individual rats. It is possible ...
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A Wnt1 regulated Frizzled-1/β-Cateninsignaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
... DA neuron exposure to either SD or 6-OHDA significantly down-regulated Fzd- 1 but not Fzd-2 or Fzd-6, while a slight reduction was observed for Fzd-3, but no diference for Fzd-8 and Fzd- 9 mRNAs (Figure 4A), ...
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α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation
... reactive astrocytes by downregulating phosphorylation of Erk1/2 and p38 MAPKs. Erk1/2 [14] and p38 [15] MAPK pathways were originally identified as signaling cascades activated by pro-inflammatory stimuli and cellular ...
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Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson’s Disease
... A large variety of ligands and receptors are involved in Wnt signal transduction. Additionally, the cell tissue specificity of Wnt/Fzd interactions and the target genes implicated in a particular cellular context, ...
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Aron, Liviu (2010): Genetic analysis of dopaminergic neuron survival: GDNF/Ret signaling and the Parkinson’s disease-associated gene DJ-1. Dissertation, LMU München: Fakultät für Biologie
... To investigate whether DJ-1 interacts with the Ras/ERK pathway, I used constitutively active versions of Ras and the MAPK ERK/rolled (rl), which impair eye development by promoting excessive proliferation and altered ...
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Gabapentin regulates dopaminergic neuron firing and theta oscillation in the ventral tegmental area to reverse depression-like behavior in chronic neuropathic pain state
... impact the functions of midbrain DA system. In this study, a neuropathic pain model [spare nerve injury (SNI)] was used to induce chronic pain stimulus as a long-time nociception to evoke depression-like behaviors. We ...
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Original Article Nicotinamide mononucleotide adenylyltransferase 1 ameliorates dopaminergic neuron death via attenuating apoptosis and oxidation in MPTP-treated mice
... Compared with the mice from the vehicle group, the mice from the MPTP group manifested PD symptoms such as decreased body weight and reduced autonomic activity. The rotarod test was used to evaluate the motor ...
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Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2
... Next, we wanted to investigate the phenotype of the remaining cell accumulation in the Ngn2 mutants in more detail. The proliferative marker Ki67 (data not shown) and BrdU labeling at E13.5 showed that proliferation was ...
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Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells
... mDA neuron fate speci- fication during foetal ...mDA neuron lineage markers have greatly facilitated the assessment of 'authentic' mDA neural phe- notype that can be derived from ES ...mDA neuron ...
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Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation
... ALDH1A1-positive DA neurons exhibit a conserved topographic dis- tribution in human SNpc and show reduction of ALDH1A1 expression in PD. (A) Representative bright-field image shows ALDH1A1 staining (purple) in SNpc ...
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