dorsal-horn
TWIK Related Spinal Cord K+ Channel Expression Is Increased in the Spinal Dorsal Horn after Spinal Nerve Ligation
... spinal dorsal horn of spinal nerve ligation (SNL) ...ipsilateral dorsal horn (C) ...spinal dorsal horn ...the dorsal horn (dot-line) was significantly higher than ...
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Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord
... BrdU labeling and detection by immunocytochemistry Pregnant female mice derived from timed matings between Lmx1b or Rnx or Drg11 heterozygous mice were given a single intraperitoneal injection of BrdU (5 mg/ml solution ...
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The role of Cx36 and Cx43 in 4‐aminopyridine‐induced rhythmic activity in the spinal nociceptive dorsal horn: an electrophysiological study in vitro
... Previously, we characterized a novel form of rhythmic activity that is manifested within nociceptive circuitry of neonatal rat substantia gelatinosa (SG) in vitro and is reliant on the chemical and electrical ...
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Periaqueductal grey EP3 receptors facilitate spinal nociception in arthritic secondary hypersensitivity
... strength produces LTP at C-fiber synapses only when descending controls are disrupted (Liu et al., 1998). C-nociceptive drive from the primary injury site may affect the spinal processing of A-nociceptor inputs from the ...
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Periaqueductal grey cyclooxygenase dependent facilitation of C nociceptive drive and encoding in dorsal horn neurons in the rat
... alters dorsal horn neuronal activity (Carlsson et ...spinal dorsal horn, to provide further insights into the neuronal mechanisms under- lying differential control of A- and C-fibre-evoked ...
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Analgesic effect of percutaneously absorbed non steroidal anti inflammatory drugs: an experimental study in a rat acute inflammation model
... Histological findings were analyzed using 25 rats (n = 5 per group). Paws were treated with treated or control sheets immediately after 10% yeast suspension injection. Two sheets were adhered on the dorsal and ...
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Monocytes expressing CX3CR1 orchestrate the development of vincristine induced pain
... cancer chemotherapy-induced neuropathies provide evidence for the development of mechanical and cold allodynia and some delayed loss of intraepidermal nerve fibers in the plantar skin of the rat hind paw (14) but neither ...
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Original Article Involvement of P2X7 receptors and downstream ERK pathways in chronic inflammatory pain
... spinal dorsal horn of nerve injuries [15, ...of dorsal horn neurons and dorsal horn tissue remodeling, which is the main cause of chronic pain mainte- nance ...
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Diabetes induced microvascular complications at the level of the spinal cord: a contributing factor in diabetic neuropathic pain
... animal. Dorsal horn spinal cords (Lamina I–V) were imaged with the confocal microscope as described above, and vessels were identified through CD31 and IB 4 ...
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Reverse transcription quantitative real time polymerase chain reaction reference genes in the spared nerve injury model of neuropathic pain: validation and literature search
... the dorsal root ganglion (DRG) or the sec- ondary neurons in the dorsal horn projecting into the brain, glial cells also react dramatically to a peripheral nerve injury like ...
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Immediate effects of spinal manipulation on thermal pain sensitivity: an experimental study
... Our second purpose was to investigate whether SMT hypoalgesia differed from physical activity for first pain response or temporal summation. This purpose adds to the existing literature because previous studies of SMT ...
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VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis
... the dorsal horn 8 and 11 days following induction of inflammatory arthritis ...the dorsal horn in (e-f) non-inflamed control, (g-j) day eight and (k-l) day 11 following induction of articular ...
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Phosphorylation state–dependent modulation of spinal glycine receptors alleviates inflammatory pain
... density of α3GlyRs (6). To this end, we prepared lumbar spinal cord slices from VGAT::ChR2 BAC transgenic mice (29), which permit selective activation of inhibitory neurons through short pulses of blue light (30). In ...
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The role of Cx36 and Cx43 in 4‐aminopyridine‐induced rhythmic activity in the spinal nociceptive dorsal horn: an electrophysiological study in vitro
... Previously, we characterized a novel form of rhythmic activity that is manifested within nociceptive circuitry of neonatal rat substantia gelatinosa (SG) in vitro and is reliant on the chemical and electrical ...
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Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents
... Effect of exogenous leptin on behavioral and cellular changes. (A–D) Intrathecal leptin (50 μ g) treatment in naive rats, given once daily for 7 days, induced thermal hyperalgesia (A) and mechanical allodynia (B) on day ...
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Semaphorin 5B is a repellent cue for sensory afferents projecting into the developing spinal cord
... the dorsal root ganglia neurons first reach the embryonic spinal cord at the dorsolateral ...longitudinal dorsal funiculus during a stereotyped waiting period of approximately 48 ...and dorsal ...
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Biology and therapy of fibromyalgia: pain in fibromyalgia syndrome
... that dorsal horn glia cells might have an important role in producing and maintaining abnormal pain sensitivity ...the dorsal horn and also enhance the hyper-excitability of the dorsal ...
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Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret
... the dorsal horn, suggesting that Nrtn acts as a diffusible guidance cue for mechanoreceptive afferent ...superficial dorsal horn by electroporation, Ret + afferents fail to invade the region ...
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Original Article Bilirubin in cerebrospinal fluid reduces nociceptive sensation through inhibition of synaptic activity of neurons in spinal cord
... spinal dorsal horn can be inhibit- ed by general ...spinal dorsal horn that closely relates to the nociceptive sensory transmission needs fur- ther ...
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Targeting the D series resolvin receptor system for the treatment of osteoarthritic pain
... ipsilateral dorsal horn of the lumbar spi- nal cord (L3–L5) on day 14 (A) and day 35 (B) in MIA-treated rats compared with saline-treated ...eral dorsal horn of the lumbar spinal cord (L3–L5) ...
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