dose-finding study
Methylene blue for malaria in Africa: results from a dose finding study in combination with chloroquine
... uncontrolled dose-finding study on the combination MB-CQ was performed in 435 young children with uncomplicated falciparum malaria in Burkina Faso (CQ monotherapy had a > 50% clinical failure rate ...
5
<p>Randomized dose-finding study of batefenterol via dry powder inhaler in patients with COPD</p>
... This study aimed to determine the minimal, optimally effec- tive dose of batefenterol, with an acceptable safety profile, in patients with stable COPD to take forward to Phase III develop- ...post- ...
15
How to design a dose-finding study using the continual reassessment method.
... Although first proposed nearly 30 years ago, the uptake of the CRM in mainstream clinical research has been un- fortunately slow [3–5, 16]. Garrett-Mayer [17] published a tutorial paper on the CRM, which described the ...
15
A pilot dose finding study of pioglitazone in autistic children
... at study entry were re- quired to be stable on such interventions (continuous participation during the preceding 3 months) and to not electively initiate new or modify ongoing interventions for the duration of the ...
14
Oral intake of phenylbutyrate with or without vitamin D3upregulates the cathelicidin LL-37 in human macrophages: a dose finding study for treatment of tuberculosis
... The study was supported by icddr,b, ‘ the Swedish Agency for Research Cooperation with Developing Countries (Sida/SAREC Agreement support; grant 384, SWE-2008-065) ’ ; ‘ The Swedish Research Council, (grant 58X- ...
8
An open-label, sequential, dose-finding study of peginesatide for the maintenance treatment of anemia in chronic hemodialysis patients
... first dose of peginesatide, each patient’s sub- sequent doses were adjusted using predetermined guidelines (Additional file 2: Table S2) to maintain Hb within ...last dose (unless they were en- rolled in a ...
10
Evaluation of Mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study
... follow study protocol, were preg- nant or lactating and had any medical condition which in the opinion of the investigator might interfere with the subject's ability in the ...
7
<p>A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia</p>
... Figure 3 Clinical response. (A) Waterfall plot of the maximal percentage reduction from baseline of the sum of longest diameters of target lesions for both dose-escalation and expansion phases. (B) Spider plot of ...
13
A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies.
... The design of this first-in-man study attempted to optimise the integration of the safety data, pharmacokinetics and pharmacody- namics. The concurrent assessment of various administration schedules, selected ...
8
The ED50 and ED95 of oxytocin infusion rate for maintaining uterine tone during elective caesarean delivery: a dose finding study
... this study, sealed, opaque enve- lopes were prepared using the Microsoft Excel RAND function to determine study subject ...the study prepared an oxytocin infusion according to the randomization ...
6
Interferon beta-1a for the maintenance of remission in patients with Crohn's disease: results of a phase II dose-finding study
... The most common AEs observed, such as influenza-like symptoms, headache and injection-site reactions, were more frequent in the IFN beta-1a treatment groups than in the placebo group. However, these AEs are among the ...
10
Impact of rivaroxaban on stent thrombosis and secondary prevention of cardiovascular events in acute coronary syndrome
... etexilate Dose Finding Study in Patients with Acute Coronary Syndromes; APPRAiSe-2, Apixaban for Prevention of Acute Ischemic Events; ATLAS, A Randomized, Double-Blind, Placebo-Controlled, ...
7
Cardiovascular outcomes during treatment with dabigatran: comprehensive analysis of individual subject data by treatment
... Ingelheim Study in Thrombosis; PETRO, Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrillation; RE- DEEM, RandomizEd Dabigatran Etexilate ...
17
PubMedCentral-PMC4892992.pdf
... a dose-finding study of a new derivative of thalidomide for older adults with acute myeloid ...a dose with the DLT rate of ...proposed dose-assignment algorithm would have worked if ...
16
What makes re-finding information difficult? A study of email re-finding
... example finding a password from within an ...involve finding more than one item and often require the user to process or collate information in order to solve the ...a study of the factors that ...
12
Cancer incidence in the population exposed to dioxin after the "Seveso accident": twenty years of follow-up
... The study sponsors had no role in the study design; in data analysis and interpretation; in the writing of the manuscript; or in the decision to submit the manu- ...
11
Adjuvant therapies for Parkinson’s disease: critical evaluation of safinamide
... controlled study investigated the pressor response to oral tyramine under fasting conditions after the administration of SAF at therapeutic (100 mg/d) and supratherapeutic (350 mg/d) dosing regimens in healthy ...
10
Population pharmacokinetics of vancomycin in obesity: finding the optimal dose for (morbidly) obese individuals
... PK study, which could the- oretically interfere with the ...our study were, besides being obese, otherwise healthy individuals with adequate renal ...
15
A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies
... The model-based approaches such as CRM and the mod- ified CRMs are widely used in single-agent dose-finding clinical trials. However, parametric modeling of F( · ) may be problematical when there is little ...
13
Solifenacin/tamsulosin fixed-dose combination therapy to treat lower urinary tract symptoms in patients with benign prostatic hyperplasia
... were 0.4/6 or 0.4/9 mg. The two primary efficacy variables were the total IPSS and the Total Urgency and Frequency Score (TUFS). According to the study results, the 0.4/6 mg FDC was superior to placebo and ...
10