Double-fixed dose combination
Fixed-dose combinations in type 2 diabetes – role of the canagliflozin metformin combination
... randomized, double-blind, placebo and active control period and a double-blind active control ...stable dose of metformin of at least 1,500 mg or more with an HbA 1c greater than ...
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Efficacy of tiotropium–olodaterol fixed-dose combination in COPD
... and double-blind design, their external validity might be limited due to a (highly) selected COPD patient population that is not representative of the full spectrum of COPD patients seen in clinical ...
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MONTELUKAST AND LEVOCETERIZINE FIXED DOSE COMBINATION-AN EVIDENCE REVIEW
... irrational combination of Montelukast and ...randomized, double- blind, parallel, active controlled, comparative four week trial in 70 patients with allergic rhinitis (AR) concluded that the mean change of ...
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Cost-effectiveness analysis of a fixed-dose combination of indacaterol and glycopyrronium as maintenance treatment for COPD
... This study was conducted from the perspective of the third-party payer; therefore, we included only direct costs in our analysis. Costs associated with COPD maintenance, exacerbation, and drugs were obtained from NHI ...
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DEVELOPMENT AND OPTIMIZATION OF FIXED DOSE ANTIHYPERTENSIVE COMBINATION DRUGS USING DOUBLE LAYER SUSTAINED RELEASE MICROSPHERE TECHNOLOGY
... form double-walledmicrospheres, two polymer solutions are briefly mixed before adding to the aqueous non-solvent ...hypertension, combination therapy is ...withlow dose combination is being ...
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Capillary electrophoresis for the assay of fixed dose combination tablets of artesunate and amodiaquine
... is uncharged (eluted in the EOF at 0% SDS concentration), partitions through hydrophobic interactions and is eluted late. Selectivity was adjusted by varying the SDS concen- tration. Increasing SDS concentration has ...
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Design of Experiments for Coating Process of Valsartan and Pravastatin Fixed-dose Combination Tablet
... Inc., Richmond Hill, Canada) until the predefined loss on drying (LOD) of approximately 1.5% w/w. Dry granulates were screened (Quadro Comil197S, Quadro Engineering, Canada) using a 990 μm screen at 1,200 rpm. ...
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SIMULTANEOUS ESTIMATION OF VALSARTAN AND HYDROCHLOROTHIAZIDE IN FIXED DOSE COMBINATION IN UV SPECTROPHOTOMETRY
... JASCO double beam UV/Visible spectrophotometer (Model V-530) was used with slit width fixed at 2nm, equipped with spectra manager software (Version ...
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Critical appraisal of a fixed combination of esomeprazole and low dose aspirin in risk reduction
... prospective, double-blind, randomized, controlled study of 170 ...low dose and were expected to require continuous treatment with low dose aspirin were randomly assigned to treatment with ...
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Spotlight on valsartan–sacubitril fixed-dose combination for heart failure: the evidence to date
... neprilysin inhibitor sacubitril with the ARB valsartan rep- resents an attempt to further improve the bad prognosis of HF, reducing the risk of cardiovascular death and hospital- ization rate linked to HF. Sacubitril was ...
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Fixed-dose combination of sitagliptin and metformin for the treatment of type 2 diabetes
... of combination therapy with sitagliptin and ...parallel-group, double-blind study of 1,091 patients with T2DM who were inadequately controlled on diet and exercise alone (A1C of ...
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SIMULTANEOUS DETERMINATION OF SALBUTAMOL AND AMBROXOL IN FIXED DOSE COMBINATION BY SPECTROPHOTOMETRY
... Instrumentation: For the present study JASCO double beam UV/Visible spectrophotometer(Model V-630) was used with slit width fixed at 1.5nm ,equipped with spectra manager software (Version 1.5). Pair of 1-cm ...
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Amlodipine and valsartan as components of a rational and effective fixed-dose combination
... 8-week, double-blind, active-treatment period (Study 1:amlodipine in daily doses of ...in combination, or placebo; Study 2: amlodipine in a daily dose of 10 mg, valsartan in daily doses of 160 or 320 ...
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Profile of a fixed-dose combination of tiotropium/olodaterol and its potential in the treatment of COPD
... randomized, double-blind, five-arm, parallel group studies randomizing a total of 5,163 COPD patients across the spectrum of disease severity from GOLD stage 2 to GOLD stage 4 at more than 500 trial sites in ...
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REVIEW ON THE FIXED DOSE COMBINATION DRUGS AND THEIR INCOMPATIBILITIES
... Bilayer tablet: The purpose of this dosage form was to develop a stable formulation of Antihypertensive drugs of the Telmisartan and Hydrochlorothiazide immediate release bilayer tablet and to study the dissolution ...
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Efficacy of fixed dose amlodipine and losartan combination compared with amlodipine monotherapy in stage 2 hypertension: a randomized, double blind, multicenter study
... multi-center, double-blind, randomized study, adult patients (n = 148) with stage 2 hypertension were randomized to amlodipine 5 mg/losartan 50 mg or amlodipine 5 ...the combination group ...the ...
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Formulation and Development of Fixed Dose Combination of Artemether and Lumefantrine Tablets for the Treatment of Malaria.
... Malaria causes about 400-900 million cases of fever and approximately 2-3 million deaths annually which represents one death every 15 seconds. The vast majority of cases occur in children under 5 years pregnant women are ...
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THERAPEUTIC EFFICACY OF HYDROCHLOROTHIAZIDE WITH LOSARTAN AS A FIXED DOSE COMBINATION BY LC-MS/MS
... a fixed dose combined drug in treatment of ...received fixed dose and single dose product based on the randomization code in each clinical ...of fixed dose combining drug ...
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Safety and effectiveness of a fixed-dose combination of olmesartan, amlodipine, and hydrochlorothiazide in clinical practice
... The following five dose levels of the olmesartan/ amlodipine/HCT FDC tablet were used: 20/5/12.5 mg, 40/5/12.5 mg, 40/5/25 mg, 40/10/12.5 mg, and 40/10/25 mg. Up- or down-titration of the FDC tablet dose ...
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Aclidinium bromide/formoterol fixed-dose combination therapy for COPD: the evidence to date
... formoterol combination on isolated human bronchial ...the combination model indicated a synergistic action at the low doses of aclidinium and formoterol in inducing smooth muscle relaxation in ...
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