Double-strand break repair
MTE1 Functions with MPH1 in Double-Strand Break Repair
... ABSTRACT Double-strand DNA breaks occur upon exposure of cells to ionizing radiation and certain chemical agents or indirectly through replication fork collapse at DNA damage ...unrepaired, ...
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Double-Strand Break Repair by Non-homologous End-Joining
... of double strand break repair (DSBR) which is largely conserved from yeast to ...the repair of radiation-induced double-strand breaks ...for repair of ionising ...
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Differential Usage of Alternative Pathways of Double-Strand Break Repair in Drosophila
... conversion repair, the frequency of mitotic crossing over in the germ line indicates the relative prevalence of repair by double Holliday junction (DHJ) formation ...synthesis-dependent strand ...
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Evidence for conservative (two-progeny) DNA double-strand break repair.
... Intramolecular double-strand break repair in the RecE pathway (in a recBC sbcA strain): As our aim is in demonstration of intramolecular recombination and, therefore, cons[r] ...
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Coordination of DNA Ends During Double-Strand-Break Repair in Bacteriophage T4
... of double-strand-break repair (DSBR) proposes that each end of a double-strand break (DSB) is repaired independently by initiating extensive semiconser- vative DNA ...
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Update on DNA-Double Strand Break Repair Defects in Combined Primary Immunodeficiency
... of lymphoid tumours. Immunodeficiency may lead to frequent sinopulmonary infections that in conjunction with recurrent aspiration, lead to chronic lung disease [ 37 ]. Interstitial lung disease, including lymphoid ...
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DNA Double Strand Break Repair and its Association with Inherited Predispositions to Breast Cancer
... DNA repair mechanisms that include DNA mismatch repair, nucleotide excision repair, base excision repair and DNA double strand break ...
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The Roles of REV3 and RAD57 in Double-Strand-Break-Repair-Induced Mutagenesis of Saccharomyces cerevisiae
... of intact yeast cells treated with alkali cations. J. Bacteriol. 153: comments and suggestions on the manuscript. We also thank D. 163–168. Schild, A. Morrison, and R. Keil for providing plasmids, H. Tran and Ivanov, E. ...
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Regulation of DNA Double-Strand Break Repair by
... ribonucleoprotein U-like 1 (hnRNPUL1) as an RNA binding protein that specifically associated with 307 DDSR1, is recruited to sites of double-strand breaks and is important for end resection during 308 ...
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Drosophila ATR in Double-Strand Break Repair
... detect repair defects in grp or lok single ...HR repair of DSBs generated by P-element excision in different tissues, throughout ...SDSA repair, but there is at present no evidence that these ...
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Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
... to repair chro- mosomal SSBs induced by IR [this work and ( 54 ...in repair of IR-induced SSBs implicates reduced PNKP-dependent DNA phosphatase activity in the development of ...
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Distinct functions of BRCA1 and BRCA2 in double strand break repair
... Indeed, to our knowledge, a ‘protein complex’ that contains BRCA1, BRCA2 and RAD51 has yet to be isolated. More- over, it should be emphasized that most of the proteins that have been shown to interact with BRCA1 fail to ...
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DNA synthesis errors associated with double-strand-break repair.
... In contrast to the spontaneous revertants that were found equally on both chromosomes, it is remarkable that nearly all the revertants were on the chromosome that had th[r] ...
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The Effect of Gap Length on Double-Strand Break Repair in Drosophila
... Figure 1B shows the detailed mating scheme and lists eight types of offspring classified according to the mark- ers on chromosome 2. Gap formation and repair occur in the germ cells of males and are detected among ...
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A Genetic Screen For DNA Double-Strand Break Repair Mutations in Drosophila
... DNA double-strand break (DSB) repair has been greatly facilitated by the use of rare- cutting endonucleases, which induce a break precisely at their cut sites that can be strategically ...
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Functional Analysis of Maize RAD51 in Meiosis and Double-Strand Break Repair
... rad51 double mutants are euploid and exhibit near-normal rates of meiotic ...rad51 double mutant embryos are extremely susceptible to radiation-induced DSBs demonstrates a conserved role for RAD51 in the ...
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The role of homologous recombination in mitotic and meiotic double-strand break repair
... the double mutant no aggravation of this phenotype was ...the double mutant in two of the assays performed, several explanations are ...the double mutant leads to additive ...the double mutant ...
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Genetic Requirements for the Single-Strand Annealing Pathway of Double-Strand Break Repair in Saccharomyces cerevisiae
... A densitometric analysis of these data showed that in the wild-type strain (Figure 5a) the whole recombina- tion product (deletion plus gene conversion) repre- sented alm[r] ...
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Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms.
... DNA double stranded breaks (DSBs) are one of the most deleterious types of DNA ...DSB repair if longer microhomologies are present, the majority of DSBs were repaired using the highly error-prone SD-MMEJ ...
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Genetic and physical analysis of double-strand break repair and recombination in Saccharomyces cerevisiae.
... LACZ gene on a centromere-containing plasmid such that no functional @-galactosidase was produced. This construction also includes another promoterless copy of LACZ, containi[r] ...
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