Doxorubicin resistance
Original Article Identification of gene expression profiles associated with doxorubicin resistance in paired doxorubicin-resistant and doxorubicin-sensitive osteosarcoma cell lines
... multidrug resistance in OS, many methods targeting key molecules or signal transduction pathways have been established, including siRNA, small bioactive molecules, and extracts based on Chinese ...drug ...
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Factors Secreted by Human Neuroblastoma Mediate Doxorubicin Resistance by Activating STAT3 and Inhibiting Apoptosis
... of doxorubicin (Fig. 6B) and in- hibition of doxorubicin-induced DNA fragmenta- tion ...of doxorubicin- induced toxicity and inhibition of ...
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A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells
... 28. Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, Driggers EM, Zhang J, Bailey ST, Sharpless NE, Hayes DN, Patel NM, Janne ...
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miR-145 sensitizes breast cancer to doxorubicin by targeting multidrug resistance-associated protein-1
... in doxorubicin resistant MCF-7 cells (MCF-7/ADR) compared with parental MCF-7 cells (Figure 1C and ...MCF-7 doxorubicin resistance and the data showed: a) miR-145 expression level increased a little ...
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Alterations of ionic membrane permeabilities in multidrug resistant neuroblastoma x glioma hybrid cells
... drug resistance is accompanied by several alterations in ionic membrane ...drug resistance (see Introduction), one can ask whether the V-ATPase contributes in some way to doxorubicin ...to ...
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Attenuation of STAT3 Phosphorylation Promotes Apoptosis and Chemosensitivity in Human Osteosarcoma Induced by Raddeanin A
... increased doxorubicin toxicity by increasing its cellular uptake, ablating efflux and downregulating MDR1 in drug-resistant cells with attenuation of STAT3 ...of doxorubicin resistance in ...
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Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors
... of doxorubicin in JC tumors, which were fully refractory to the ...and doxorubicin was more effective than the combination of ZA and ...of doxorubicin resistance in NZ-treated animals was ...
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Drug Resistance in Lung Cancer
... and doxorubicin (Kelley et al, ...cisplatin resistance often, but not always show increased MT expression, suggesting that an increased MT expression alone may not be the sole mediator of cisplatin ...and ...
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Histone deacetylase 1 induced by neddylation inhibition contributes to drug resistance in acute myelogenous leukemia
... promoted doxorubicin resistance of HL-60, K562, and primary bone marrow cells (BMCs) of remission AML patients as shown by increasing cell viability and doxorubicin-releasing index, inhibiting cell ...
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Natural Products Modulate the Multifactorial Multidrug Resistance of Cancer
... multidrug resistance (MDR1) in leukemia and human colon car- cinoma, which endogenously expresses ...reversed doxorubicin resistance in both cell lines ...of doxorubicin resistance ...
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Folate-mediated mitochondrial targeting with doxorubicin- polyrotaxane nanoparticles overcomes multidrug resistance
... Functional doxorubicin (DOX) nanoparticles for targeted delivery of the classical cytotoxic anticancer drug DOX to tumor cells, using folate-terminated polyrotaxanes along with dequalinium, have been developed and ...
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The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer
... of doxorubicin (DOX) and cisplatin (CIS) on cell ...of doxorubicin and cisplatin on cell proliferation in multicellular structures and cell ...by doxorubicin and ...
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An Observational Chart Review of a Comparison of Generic to Reference Liposome-Encapsulated Doxorubicin Hydrochloride in Subjects with Epithelial Ovarian Carcinoma Who Have Failed Platinum-Based Chemotherapy Soriano RA and Gonzalez M
... Encapsulated Doxorubicin Hydrochloride Formulation in Subjects with Epithelial Ovarian Carcinoma who Have Failed platinum-Based Chemotherapy, ...liposomal doxorubicin in ovarian cancer: a meta-analysis of ...
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DOXORUBICIN AND CHLOROQUINE: A COMBINATION THERAPY TO OVERCOME THE MULTI DRUG RESISTANCE IN CANCER – A REVIEW
... ABSTRACT: Cancer is a genetic disorder that can happen to anybody; anytime. The treatment, where one or more chemotherapeutic agents (anti-cancer drugs) are used either to treat the cancer patients (curative intent with ...
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A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy
... drug resistance through a variety of mechanisms, not all of which are fully ...multidrug resistance (MDR) [3]. One key cause of acquired multidrug resistance is through energy-dependent efflux of ...
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Fasn expression correlation analysis to anti cancer drugs
... FASN resistance behaviors signify its functional association with EGFR mediated proliferatory ...positive resistance correlation with these ...showed resistance to anti-MEK therapy which is clear ...
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Original Article Increasing the cytotoxicity of doxorubicin in breast cancer MCF-7 cells with multidrug resistance using a mesoporous silica nanoparticle drug delivery system
... of resistance against the anticancer agents ...multidrug resistance (MDR1) phenotype in advanced breast cancer is primarily responsible for the failure of current treatment regimens [2, ...
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The intratumoral administration of ferucarbotran conjugated with doxorubicin improved therapeutic effect by magnetic hyperthermia combined with pharmacotherapy in a hepatocellular carcinoma model
... Hep3B, a human HCC cell-line, was transduced with a retroviral vector containing the firefly luciferase (luc) re- porter gene, and a highly expressing reporter clone was isolated to establish Hep3B + luc cells. Hep3B + ...
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Theoretical study on physicochemical and geometrical properties of Doxorubicin and its different carriers such as PEG FOL and PEO b PCL
... For doxorubicin delivery, encapsulation and micellar delivery have received increased attention because this system can protect and carry the drug directed to its intended ...
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NAP1L1 is a prognostic biomarker and contribute to doxorubicin chemotherapy resistance in human hepatocellular carcinoma
... The functions of NAP1L proteins that have been attrib- uted include nucleosome assembly, histone transport, histone eviction, transcriptional regulation, and cell cycle progression [8]. NAP1L1 can be detected in most ...
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