DRAINING LYMPH-NODES
TIM-4 is differentially expressed in the distinct subsets of dendritic cells in skin and skin-draining lymph nodes and controls skin Langerhans cell homeostasis
... its draining lymph nodes (LN), are essential mediators of immunity and tolerance ...its draining LNs, which differ in phenotype and function, are also potent immune modulators ...
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Intramuscular Inoculation of Mice with the Live-Attenuated Recombinant Rabies Virus TriGAS Results in a Transient Infection of the Draining Lymph Nodes and a Robust, Long-Lasting Protective Immune Response against Rabies
... tissue, draining lymph nodes, spleen, spinal cord, and brain at different times after TriGAS inoculation revealed the presence of significant copy numbers of RABV-specific RNA in muscle, lymph ...
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Vaccine draining lymph nodes of cancer patients for generating anti cancer antibodies
... In the UVA study as well as other vaccine studies, positive clinical outcomes were associated with elevated serum titers of anti-vaccine antibodies [2, 6, 7]. In ani- mals, vaccine-induced antibodies can prevent tumor ...
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Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy
... tumor-draining lymph nodes (TDLNs) for checkpoint therapy are ...cells. Lymph nodes (LNs) play important roles in the generation and regulation of immune responses to pathogens and ...
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Spatial organization of dendritic cells within tumor draining lymph nodes impacts clinical outcome in breast cancer patients
... To our knowledge, this is the first report on DC spatial organization in the context of human cancer. Prior studies on DC clustering suggested that 1) cluster- ing is associated with DC maturation, and 2) clustering ...
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Expression of indoleamine 2,3 dioxygenase by plasmacytoid dendritic cells in tumor draining lymph nodes
... in draining LNs follow- ing adoptive transfer was prevented by coadministration of 1MT (and was thus IDO-dependent), but it was not clear whether the relevant IDO was expressed by the adoptively transferred DCs, ...
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Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes
... the draining LN have been ...the draining LN was observed earlier in a few experiments using sophisticated immu nization pro tocols and adoptive transfer of lymphocytes, high doses (20–25 μg) C and ...
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Generation of experimental allergic airways inflammation in the absence of draining lymph nodes
... Our current understanding of the generation of mucosal immunity is that antigens penetrating mucosae are captured by DCs and transported to the draining LNs to initiate immune responses (7). The data presented ...
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Vesicular Stomatitis Virus Oncolytic Treatment Interferes with Tumor-Associated Dendritic Cell Functions and Abrogates Tumor Antigen Presentation
... the draining lymph nodes to initiate an antigen-specific immune response (19, ...the draining lymph nodes after VSV ...tumor draining lymph nodes, ...
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p19/Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis.
... Murine cancer models have been useful to define the critical genes and multi-step pathways involved in generation of cancers. However, most mouse cancer models rarely develop metastasis to secondary organs, so that the ...
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Interaction of biomedical nanoparticles with the pulmonary immune system
... Engineered nanoparticles (NPs) offer site‑specific delivery, deposition and cellular uptake due to their unique phys‑ icochemical properties and were shown to modulate immune responses. The respiratory tract with its ...
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Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy
... Subsequently, these cells — triggered by cytokines such as TNF-α and IL-1β — migrate to the draining lymph nodes Nonstandard abbreviations used: BMDM, BM-derived macrophages; CHS, contac[r] ...
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Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma
... in draining lymph nodes, which is responsible for the alleviation of experimental allergic airway disease ...in draining lymph nodes and the ensuing immunopatho- logical ...
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Toxic Shock Syndrome Toxin 1 Evaluation and Antibiotic Impact in a Transgenic Model of Staphylococcal Soft Tissue Infection
... ABSTRACT Nonmenstrual toxic shock syndrome (nmTSS), linked to TSST-1-producing CC30 Staphylococcus aureus, is the leading manifestation of toxic shock syndrome (TSS). Due to case rarity and a lack of tractable animal ...
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Indoleamine 2,3 dioxygenase and tumor induced tolerance
... Tumors arise from normal cells of the body through genetic mutation. Although such genetic mutation often leads to the expression of abnormal antigens, the immune system fails to respond effectively to these antigens; ...
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HIV Immunopathogenesis: Inhibition of CD4+ T Cell Activation
... in lymph nodes early after ...in draining lymph ...allowed draining lymph nodes for each antigen to be obtained at the same time, thus allowing direct comparisons of the ...
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Cells expressing herpes simplex virus glycoprotein gC but not gB, gD, or gE are recognized by murine virus-specific cytotoxic T lymphocytes.
... Thus, it appears that effector CTL obtained from draining lymph nodes of intravaginally infected mice were unable to kill syngeneic target cells transfected with and expressing HSV-2 gD [r] ...
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Skin exposure promotes a Th2 dependent sensitization to peanut allergens
... in the draining lymph nodes. Furthermore, purified DCs from pea- nut-exposed mice were able to induce Th2 responses from naive T cells in the absence of any other accessory cells, suggesting that DCs ...
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In vivo effects of a recombinant vaccinia virus expressing a mouse mammary tumor virus superantigen.
... six draining lymph nodes were collected 2 days after infection and stained for B cell- and macrophage-specific ...total lymph node cells (To) and from sorted populations of B cells (B), ...
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Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood
... Oakville, Ontario, Canada) of the common bile duct and separated on a dextran gradient. Islets were dispersed into single cells to liberate lymphocytes by incubation with Cell Dissociation Buffer (Life Technologies Inc., ...
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