drug concentrations
Lack of Prophylactic Efficacy of Oral Maraviroc in Macaques despite High Drug Concentrations in Rectal Tissues
... in drug penetration and susceptibility to infection be- tween rectal and vaginal tissues (42, ...tissue drug accumu- lation and maintains systemic drug concentrations, which may both be ...
10
Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
... (CNS) drug development suffers from 91% attrition rate and especially the success rate in phase II is very low ...site concentrations, target interaction and downstream signal ...novel drug ...
222
P glycoprotein expression and function, relationship to plasma and intracellular drug concentrations, and the effects of HIV disease
... com pared w ith untreated controls. Few clinical studies have considered P-gp expression and function in the context o f the spectrum o f HIV disease, its treatm ent and plasm a HIV RNA levels. Chaillou and ...
183
Measurement of adherence, drug concentrations and the effectiveness of artemether lumefantrine, chlorproguanil dapsone or sulphadoxine pyrimethamine in the treatment of uncomplicated malaria in Malawi
... As part of efforts to optimize the operational use of AL, it is important to assess the effect of poor adherence to (compliance with) this regime on clinical outcome. This paper describes a large single centre open label ...
11
Structure-based prediction of anti-infective drug concentrations in the human lung epithelial lining fluid
... The plasma and ELF concentration data included concen- trations that were below the lower limit of quantification (LLOQ). Different scenarios were identified for either the plasma or the ELF observations, or both, being ...
12
Cost-effectiveness of routine measuring of serum drug concentrations and anti-drug antibodies in treatment of rheumatoid arthritis patients with TNF-α blockers
... serum concentrations of biologicals in treatment of rheumatoid arthritis could provide an explanation for a loss of efficacy and help in the choice of subsequent ...adalimumab drug trough level (DL) and ...
7
Chronotherapeutic Drug Delivery Systems: An approach to synchronize drug concentrations to circadian rhythms in disease state.
... the drug coincide with peak ...anti-inflammatory drug such as Ibuprofen would be around noon or ...same drug would be more effective for people with rheumatoid arthritis when taken after the evening ...
5
Modelling arterial wall drug concentrations following the insertion of a drug-eluting stent
... governing drug release and distribution following stenting currently limits the opti- misation of such drug release ...the drug release ...experimental drug release of everolimus from a ...
24
Modeling arterial wall drug concentrations following the insertion of a drug-eluting stent
... such drug release ...the drug release ...experimental drug release of everolimus from a Dynalink-E polymer coated ...of drug elution which were then verified using empirical data from stented ...
25
Lipid nanoparticles for cyclosporine A administration: development, characterization, and in vitro evaluation of their immunosuppression activity
... The influence of the initial amount of drug used to prepare the nanosystems was investigated in terms of particle size, PDI, and drug EE. For this study LN Lec:TC was selected since Lec:TC are known to ...
13
A Review On Current Approaches In Floating Drug Delivery System
... the drug from the floating systems to the stomach may be advantageous for local therapy in the stomach and the small ...of drug concentration: Continuous input of the drug following floating system ...
15
An automated semi quantitative broad drug screen in whole blood
... 9.3.1.2 Estimation of the Concentration in Blood of Identified Drugs Data in Table 9.2 compare the drug concentrations estimated by the automated drug screening procedure Sections 8.3.3.[r] ...
231
Susceptibility testing of slowly growing mycobacteria by a microdilution MIC method with 7H9 broth
... As previously noted, the current single-drug concentrations of INH and STR which are used in the proportion method usually do not allow one to distinguish primary drug resistance from ac[r] ...
6
Kinetics for Drug Discovery: an industry-driven effort to target drug residence time
... total drug concentration-time profiles in plasma and in target ...total drug concentration in a reference tissue without the drug target and the respective target tissue provides information on the ...
37
Medication adherence during laboratory workup for primary aldosteronism: pilot study
... All new referrals at our hypertension clinic were routinely subjected to our standardized laboratory protocol for secondary hypertension and aldosteronism. On the first visit, clinical routine workup was done, prescribed ...
7
Integrating heterogeneous drug sensitivity data from cancer pharmacogenomic studies
... of Drug Sensitivity in Cancer (GDSC) [2] and the Cancer Therapeutics Response Portal (CTRP) [3] projects have systematically collected drug sensitivity profiles and genomic information across hundreds of ...
7
Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion
... By hospital day #6 the patient’s CBZ level had elevated to nearly the same peak level as recorded in the first 48 hours of toxicity. This may have been due to retained drug in the gut, impaired hepatic metabolism, ...
5
Pharmacokinetics and oral bioavailability of metformin hydrochloride in healthy mixed-breed dogs
... serum drug and blood lactate concentrations before treatment initiation (baseline) and just before the morning drug administration on days 2, 4, and 6; a final blood sample was collected for analysis ...
8
Biomaterial modification of urinary catheters with antimicrobials to give long term broadspectrum antibiofilm activity
... It is important that any post-manufacture processing does not dam- age the biomaterial, and the in fl atable retention balloon is an obvious site of susceptibility for any deterioration in mechanical properties. In ...
8
The effects of age and liver disease on the disposition and elimination of diazepam in adult man
... This study investigates the separate effects of age and hepatocellular liver disease on the disposition and elimination of diazepam (Valium) in man. The drug was given either by rapid intravenous injection (0.1 ...
14