drug deposition
Development of buccal adhesive tablet with prolonged antifungal activity: Optimization and ex vivo deposition studies
... desired drug release and ...vitro drug release of the prepared tablet was determined. The drug release and bioadhesion was dependent on type and relative amounts of the ...permeation, drug ...
5
Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition
... nasal drug delivery systems for ...mucosal drug retention, and the highest nasal drug deposition with the least permeation ...the drug suspension and the marketed ...
13
<p>Novel Approach for Transdermal Delivery of Rifampicin to Induce Synergistic Antimycobacterial Effects Against Cutaneous and Systemic Tuberculosis Using a Cationic Nanoemulsion Gel</p>
... and Drug Deposition Studies Formulations intended for transdermal delivery require skin permeation studies to determine the skin permeation coef fi cient (Pc), cumulative amount of drug permeated, lag ...
22
Systems pharmacology approach for prediction of pulmonary and systemic pharmacokinetics and receptor occupancy of inhaled drugs
... Pulmonary drug disposition after inhalation is complex involving mechanisms, such as regional drug deposition, dissolution, and mucociliary ...When drug- and formulation-specific properties ...
11
MICROSPONGES AS THE VERSATILE TOOL FOR TOPICAL ROUTE: A REVIEW
... enhanced drug deposition in the skin. In-vitro drug release, ex- vivo drug deposition, and in-vivo antibacterial activity of mupirocin loaded formulations were ...between drug ...
12
Journal of Biomedical Engineering and Technology
... the drug deposition to the effected region in case of airway dysfunction ...different drug delivery systems and inhalation approaches, as the deposition of aerosol in the human respiratory ...
5
Microsponge based drug delivery system of voriconazole for fungal infection: formulation development and In-vitro evaluation
... Voriconazole plain gel (VLG) and voriconazole microsponge (VLMSG) formulations containing 1 mg equivalent of VL were applied on the skin and smoothly distributed on the marked area of different groups. At the end of 12 ...
10
Current Development in the Evaluation Methods of Pulmonary Drug Delivery System
... pulmonary drug delivery system offers several merits over other drug delivery systems and therefore, this delivery route has been in prime focus for various applications like local and systemic therapeutics ...
13
DEVELOPMENT AND OPTIMIZATION OF VITAMIN E ACETATE LOADED LIPOSOMES
... of drug deposition in the skin which includes diffusion, microdialysis, microscopic studies, ...with drug deposition determined by diffusion method, which is most widely used ...method. ...
15
MICROSPONGE DELIVERY SYSTEM (MDS): A UNIQUE TECHNOLOGY FOR DELIVERY OF ACTIVE INGREDIENTS
... enhanced drug deposition in the skin. In-vitro drug release, ex- vivo drug deposition, and in-vivo antibacterial activity of mupirocin loaded formulations were ...between drug ...
12
“IN-VIVO – IN-VITRO CORRELATIONS FOR RESPIRATORY DRUG DELIVERY” by Chandrakant S. Gavale*, Vaishali R. Mahajan, Mahadev S. Lohar, Anup M. Akarte, Dheeraj T. Baviskar, India.
... cavity deposition and clearance, to look for correlations between drug deposition and subsequent blood levels of systemically acting drugs, for quantifying how much drug reaches specific ...
10
MICROSPONGE AS A NOVEL DRUG DELIVERY SYSTEM
... base. Drug release through cellulose dialysis membrane showed diffusion controlled release pattern and drug deposition studies using rat abdominal skin exhibited significant retention of active in ...
9
Pharmacokinetics and biodistribution of polymeric micelles containing miRNA and small-molecule drug in orthotopic pancreatic tumor-bearing mice
... also determined, and results are shown in Figure 7. At the initial time point post-injection (0.083 h), higher GDC-0449 concentrations in the emulsion-treated group were found in the liver, kidney, and spleen compared to ...
17
Modelling the inhalation of drug aerosols in a human nasal cavity
... rect drug delivery into the blood ...early deposition due to inertial impaction. In this study low-density drug particles and submicron particles (including nanoparticles) are used to evaluate their ...
7
FORMULATION AND EVALUATION OF PREDNISOLONE PROLIPOSOMAL GEL FOR EFFECTIVE TOPICAL PHARMACOTHERAPY
... –arthritic drug, prednisolone were found to increase the skin permeation and deposition showing a sustain effect when compared to marketed ...maintain drug concentration at site for longer time is ...
9
ENHANCEMENT OF DOMPERIDONE DISSOLUTION RATE VIA FORMULATION OF ADSORBATES AND CO ADSORBATES
... antiemetic drug; Domperidone (DMP), through the formulation of adsorbates and ...of drug onto the surface of three different adsorbents; Avicel PH 101, Florite R and Aerosil 200 was studied and Langmuir ...
10
Computer Simulation and Analysis of Nanoparticle Delivery to the Olfactory Bulb for Direct Drug Migration to the Brain.
... nanoparticle deposition efficiency is dependent on the mesh size, the time step, and the number of particles ...in deposition efficiency occurs. Furthermore, nanoparticle deposition is inversely ...
132
NOVEL, SUSTAINED-RELEASE, DRY-POWDER INHALABLE FORMULATION FOR MONTELUKAST SODIUM
... inhaled particles usually end up in the gastrointestinal tract (or the IP & PS in the ACI) after adhesion to the lactose diluent. Aerosolization of dry-powder formulations depends on bulk flow and the carrier must be ...
7
Stepping closer to treating Alzheimer’s disease patients with BACE1 inhibitor drugs
... Although not explicitly described, Eisai may have also identified its potent BACE1 inhibitor E2609 through FDBB screening. In his review, Oehlrich implied that Eisai developed its BACE1 inhibitor through several series ...
11
Curcumin-loaded colloidal carrier system: formulation optimization, mechanistic insight, ex vivo and in vivo evaluation
... A simple RP-HPLC method was developed and validated for the estimation of CR in the bulk drug and nanoemulsion formulation. Shimadzu HPLC equipment comprising of quaternary LC-10AVP pumps, SPD-10AVP column oven, a ...
15