drug metabolizing enzyme
Clinically relevant genetic variants of drug-metabolizing enzyme and transporter genes detected in Thai children and adolescents with autism spectrum disorder
... among drug-metabolizing enzymes and transporters (DMETs) influence the pharmacokinetic profile of drugs and exhibit intra- and interethnic variations in drug response in terms of efficacy and safety ...
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Original Article Genetic polymorphism analysis of CYP2J2 drug-metabolizing enzyme in a Chinese Zhuang population
... the drug dosage of allergic diseases, such as ebastine (which is metabolized by CYP2J2), should be adjusted according the wild-type dosages applied to the Zhuang population used as a starting point and reference ...
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A non lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice
... measured drug pharmacokinetics, and there is no reason why this approach could not also be taken in human sub- ...the drug cocktail, but not in mice that did not receive the drug ...
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Original Article Genetic analysis of drug-metabolizing enzyme CYP3A5 polymorphisms in Tibetans in China
... Abstract: Background: Different single nucleotide polymorphisms (SNPs) in gene may lead to different drug meta- bolic activity, and different SNPs may also be associated with genetic predisposition of certain ...
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Original Article Genetic polymorphisms of the drug-metabolizing enzyme cytochrome P450 2A6 in a Tibetan Chinese population
... Abstract: Detection of CYP2A6 variant alleles, and knowledge about their allelic frequency in Tibetan ethnic groups, is important to establish the clinical relevance of screening for these polymorphisms to optimize ...
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Original Article Polymorphisms of drug-metabolizing enzyme CYP2J2 in Wa population from Yunnan Province of China
... Cytochrome P450 superfamily (CYP) is a large and diverse group of membrane-associated enzymes that can catalyze many various reactions, such as oxidation, peroxidation, hydroxylation and epoxidation, to metabolize both ...
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Original Article Genetic polymorphisms and phenotypic analysis of drug-metabolizing enzyme CYP2C19 in a Li Chinese population
... CYP2C19 enzyme results in broad inter-individual variability in response to certain clinical drugs, while little is known about the genetic variation of CYP2C19 in Li Chinese popula- ...
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Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance
... II enzyme that catalyzes the glucuronidation of various endogenous compounds such as bilirubin and steroids, and exogenous com- pounds such as ...cancer drug irinotecan, a prodrug that undergoes metabolism ...
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AGE SPECIFIC VARIATIONS IN DRUG METABOLIZING ENZYMES - IMPACT ON DRUG SAFETY EVALUATION IN CHILDREN
... Adverse drug reactions (ADR) related to drug biotransformation are ...from drug accumulation due to immature drug metabolizing enzyme systems can be expected to occur in children ...
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Original Article Effects of suberoylanilide hydroxamic acid on rat cytochrome P450 enzyme activities
... In conclusion, continuous intragastric adminis- tration of SAHA for 7 days may induce the activ- ities of CYP450 isoforms CYP2C19 of rats, inhibit the activity of CYP1A2, and may slight inhibit the activity of CYP2D6 and ...
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In vitro Metabolism of Risperidone on Isolated Microsomes of Rat Liver: Metabolite Identification and Profiling by RP-HPLC and LC-MS Techniques
... An oral formulation of RIS has been approved in 1993 by US FDA for the treat- ment of schizophrenia. RIS is an atypical antipsychotic drug reported to improve both the positive and negative symptoms of ...
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Evaluation of human primary intestinal monolayers for drug metabolizing capabilities
... vivo drug-metabolizing enzyme activities, the entero- cytes and mucosa can be isolated from human small intes- tines and directly cryopreserved as multicellular fragments that retain viability and ...
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A REVIEW ON GENETIC POLYMORPHISM OF CYTOCHROME P-450 2C19 AND ITS CLINICAL VALIDITY
... (CYP) enzyme system refers to a group of related enzymes or isoenzymes located in the endoplasmic reticulum and expressed mainly in the ...important drug-metabolizing-enzyme systems in ...
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EFFECTS OF CURCUMIN ANALOGUE, 2, 6-BIS (2, 5-DIMETHOXYBENZYLIDENE) CYCLOHEXANONE (BDMC33) ON THE ACTIVITIES OF DRUG-METABOLIZING ENZYMES IN CULTURED CACO-2 CELL MODEL
... At the time intervals of 1, 2, 3 and 4 hours, attached Caco-2 cell monolayers in 6-well plate were removed from the incubator and placed on ice cold water for 10 min. The media in all wells were discarded and rinsed ...
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Gut instincts: CYP3A4 and intestinal drug metabolism
... dosed drug. The drug-metabolizing enzyme CYP3A4 is often implicated in this process, resulting, in some cases, in sys- temic exposures of less than 15% of the administered ...
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“Scientific Aspects of the Therapeutic Use of Andrographis paniculata (kalmegh): A Review” by Sonia Mol Joseph, India.
... was reported by Shukla et al. in 1992 54 . The efficacy of andrographolide and neoandrographolide against ethanol and acetaminophen induced liver damage was comparable to silymarin 55 . However previous studies were ...
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Regulation of Hepatic Drug Metabolizing Enzymes in Chronic Kidney Disease
... The absorption and bioavailability of drugs is highly variable in patients with ESRD. The mechanism for variable absorption and bioavailability is multifactorial and begins with the intestinal pH. Urea retention in ESRD ...
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Effect of honokiol on the induction of drug-metabolizing enzymes in human hepatocytes
... in drug interactions, messenger ribonucleic acid (mRNA) levels of phase I and II drug-metabolizing enzymes, including cytochrome P450 (CYP), UDP-glucuronosyltransferase (UGT), and sulfotransferase ...
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Effects of Processing on Antioxidant Capacity and Metabolizing Enzyme Inhibition of Tiger Nut Tubers
... There are a number of products on the market currently that incorporate tubers, yet tiger nut (tuber) is an underutilized crop that may have functional proper- ties. The effects of processing on antioxidant content, ...
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The Effect of AST-120 on Hepatic Metabolism and Transport in Chronic Kidney Disease
... adverse drug events since they are typically administered multiple medications concurrently and pharmacokinetic changes in the diseased state are relatively ...of drug metabolizing enzymes and ...
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