Drug Resistance
Functional miRNAs in breast cancer drug resistance
... nevertheless, drug resistance and relapse remain obstacles on the path to successful systematic ...for drug resistance have been elucidated, and miRNAs seem to play a major part in almost ...
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Drug resistance in lung cancer
... of drug resistance, patients given chemotherapy gradually develop genetic mutations with each clonal expansion of the tumor ...coexisting drug resistance of the tumors makes it even more ...
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MicroRNA-mediated drug resistance in breast cancer
... multidrug resistance in human cancer (Zhang et ...treating drug-resistant ...and drug resistance. In a systematic search for miRNAs mediating drug efficacy, miR-21 was identified as ...
15
Anthelminthic Drug Resistance in Veterinary and Human Helminths
... Recently, Elard et al (1999) developed a more simplified method for the diagnosis of BZ resistant O. (Telodorsagia) circumcincta. Using four primers (2 allele-specific and 2 allele-non- specific ones) in the same PCR, ...
11
Plasmodium falciparum drug resistance in Angola
... Efficacy clinical trials, recommended to be conducted every 2 years, constitute the gold standard for the moni- toring of drug efficacy, identification of anti-malarial drug resistance and to guide ...
11
Pattern of Drug Resistance in Pulmonary TB Patients
... of resistance to STM, adding this drug in MDR-tuberculosis suspects is probably inappropriate and may induce more resistance to other concurrently prescribed ...of resistance to EMB causes its ...
5
International Journal for Parasitology: Drugs and Drug Resistance
... Antimalarial Resistance Network, WWARN ...antimalarial resistance to collab- orate easily, and analyze studies productively (Sibley et ...patient drug levels, allelic prevalence of potential ...
8
Drug resistance in HIV-1
... phenotypic resistance o f virus isolates (Larder et ...f resistance was characterised by particular amino acid substitutions within the RT domain - D67N, K70R, T215Y/F, and ...f drug ...
279
Multiple Drug Resistance: A Fast-Growing Threat
... other resistance mechanisms contribute to the problem of this ...antibiotic resistance continues to follow this trend, it is not out of place to assume that resistance to novel antibiotics may emerge ...
12
Modeling of signaling crosstalk-mediated drug resistance and its implications on drug combination
... Biological signaling pathways in cells are known to often interact with each other via extensive signaling crosstalk. Crosstalk-linked signaling modules [20] or motifs [21, 22] may carry out key functions of the ...
12
Suppression of Drug Resistance in Dengue Virus
... all drug resistance mutations were introduced using the QuikChange site-directed mutagenesis kit (Agilent Technologies, Santa Clara, ...of drug-resistant viruses in dengue virus-infected cells in the ...
10
HIV Drug Resistance: An Overview
... Changing ARV regimens and introduction of new ARV drugs have altered drug resistance patterns in resistance human immunodeficiency virus type 1 (HIV-1) (8). The last decade has seen a significant ...
11
Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer
... Rauch, On the relationship between drug's size, cell membrane mechanical properties and high levels of multi drug resistance: a comparison to published data, Eur Biophys J Biophy, 38 200[r] ...
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Primary and Acquired Drug Resistance in Childhood Tuberculosis
... be explained by the absence of culture and antibiogram in children with TB and also the presence of a weak screening system in case of contacts of smear positive adults (specially contacts of MDR patients). Since a ...
6
Overcoming multiple drug resistance mechanisms in medulloblastoma
... Characterisation of MB cell lines and their tumour of origin To investigate the mechanisms of drug resistance in MB, we have adopted an approach that involves establishing cell lines from patients’ primary ...
14
Trastuzumab emtansine: mechanisms of action and drug resistance
... Primary resistance of HER2-positive metastatic breast cancer to T-DM1 appears to be relatively infrequent, but most patients treated with T-DM1 develop acquired drug ...of resistance are incompletely ...
12
Aberrant splicing and drug resistance in AML
... increased drug resistance ...increased resistance to mul- tiple chemotherapeutics (carboplatin, vinorelbine, doxo- rubicin, etoposide, mitoxantrone, and vincristine), while SPF45 knockdown sensitized ...
9
Genetic Architecture of Hsp90-Dependent Drug Resistance
... of drug resistance ...of resistance to the azole antifungal ...stress. Resistance to azoles is a complex trait that can arise by multiple mutations whose phenotypic conse- quences are ...
5
MULTI DRUG RESISTANCE: A NEED TO BE ATTENTION
... Multidrug resistance as the ability of a living cell to show resistance to a wide variety of structurally and functionally unrelated ...develop resistance to a broad spectrum of structurally ...
5
A database of antimalarial drug resistance
... highly drug-resistant para- ...which resistance evolves [12] and inform practical decisions about changes in drug ...of drug resistant popu- lations be "tracked" worldwide; a resistant ...
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