drug transport
Fluid Structure Interaction Analysis for Drug Transport in a Curved Stenotic Right Coronary Artery
... Such a trend was shown in quantitative results (Figure 7) as well. Figure 7(a) shows one of the sample im- ages of the deposited particles in stenotic (yellow oval) and non-stenotic area. Figure 7(b) shows quantitative ...
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Erythropoietin and Chronic Kidney Disease Alter Hepatic Expression of Cytochrome P450 Enzymes and Drug Transport Proteins
... as drug transporters OATP1B1, OATP1B3, BCRP and P-gp show different expression patterns in ESRD patients, relative to control, future studies in vitro would favour the use of primary human hepatocytes as P-gp is ...
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Quantitative Investigation of the Impact of P-glycoprotein Inhibition on Drug Transport
... on drug absorption, distribution, and excretion of a number of clinically relevant ...P-gp-mediated drug-drug interaction (DDI) has become important for drug discovery and ...the drug ...
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Liposomal delivery systems for intestinal lymphatic drug transport
... lymphatic drug transport, long-chain and unsaturated lipids are assembled into chylomicrons in ...lymphatic transport of lipophilic ...lymphatic drug transport: administration during a ...
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Residues contributing to drug transport by ABCG2 are localised to multiple drug binding pockets
... and transport by the ATP-binding cassette transporter ABCG2 is a factor in the clinical resistance to chemotherapy in leukaemia, and a contributory factor to the pharmacokinetic pro fi les of many other prescribed ...
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Characterization of Rhodamine-123 as a Tracer Dye for Use In In vitro Drug Transport Assays
... to transport substrates against their concentration gradient ...these drug transport proteins are important determi- nants of chemical pharmacokinetics [14,15], having a large impact on intracellular ...
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A multiscale analysis of drug transport and response for a multiphase tumor model
... In this section, we present an idealised model of microscale tumour growth; for the sake of generality and clarity of presentation, the model given in this section, as well as the analysis presented in section 3 and ...
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Towards an integrated systems-based modelling framework for drug transport and its effect on tumour cells
... from drug delivery to the outcome, thus including biological transport processes of drugs and cellular response and accounting for dynamics of the relevant signal ...of transport and intracellular ...
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Mathematical and computational models of drug transport in tumours
... in drug concentration in the tumour cord?” and “How do the administration schedule and cell response affect drug delivery?” Where differences do ap- pear, we will seek to explain the reasons for them and ...
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Genetic variability in drug transport, metabolism or DNA repair affecting toxicity of chemotherapy in ovarian cancer
... to drug transport, metabolism, detoxifica- tion and DNA repair could influence the cytotoxic effects associated with chemotherapy, including those involved in the transport ...
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"Mathematical Modeling Of Drug Transport From Contact Lens To Anterior Segment Of The Eye"
... By using of contact lens for therapeutically treatment may use many deficiencies seen with the typical administration of eye drop into eye. The resident time of drug at Precorneal surface area will be longer All ...
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Drug transport and drug-drug interactions at the blood-brain barrier
... as transport-‐deficient rat strain (TR-‐), was described in ...(MRP2) transport of conjugated bilirubin from the hepatocytes into the bile (Buchler et ...
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Antiepileptic drug transport at the blood-brain barrier, the role of the SLC transporter family
... chemotherapy agents. The human ABCC family has 12 members, including the cystic fibrosis transmembrane conductance regulator (CFTR) encoded by ABCC7, the sulfonylurea receptors (SURs) encoded by ABCC8 and ABCC9, and ten ...
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Fluoxetine-Resistance Genes in Caenorhabditis elegans Function in the Intestine and May Act in Drug Transport
... Fluoxetine (Prozac) is one of the most widely prescribed pharmaceuticals, yet important aspects of its mechanism of action remain unknown. We previously reported that fluoxetine and related antidepressants induce nose ...
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Quantitative Estimation of P-glycorptein-Mediated Drug Transport by Mechanistically Modeled Intrinsic Clearance
... digoxin, a P-gp substrate, in humans (55). Beyond this, P-gp is apically expressed in liver and kidney epithelia, and on the blood side of brain capillary endothelial cells. It plays a significant role in the biliary and ...
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Matrix Metalloproteinase-sensitive Multistage Nanogels Promote Drug Transport in 3D Tumor Model
... Taking this into account, we designed multistage, MMP-sensitive, peptide-crosslinked nanogels (pNGs) that present suitable sizes to potentially accumulate in tumor tissue by the EPR effect and feature a protease-mediated ...
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COLLOID MEDIATED DRUG TRANSPORT ACROSS DERMAL ROUTE: A CRITICAL REVIEW
... aggregate or capsule brings the trans-barrier diffusion to a standstill value. Externally created water activity difference is required to induce the transport. Hence, the rate of barrier penetration by permeant ...
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Hydrogels as controlled drug delivery systems: Synthesis, crosslinking, water and drug transport mechanism
... Recent developments in the field of polymer science and technology has led to the development of various stimuli sensitive hydrogels like pH, temperature sensitive, which are used for the targeted delivery of proteins to ...
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A Method of Optimizing Pharmaceutical Drug Transport Routing to Minimize Diversion and Counterfeiting.
... and Drug Administration (FDA) defines ADR as “a distributor with whom a manufacturer has established an ongoing relationship to distribute the manufacturer’s ...
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REVIEW ON ROLE OF BBB AND ITS TRANSPORT MECHANISMS IN THE DEVELOPMENT OF BRAIN TARGETED DRUG DELIVERY SYSTEMS
... on drug melding into cell ...mechanism, drug has to partition into the aqueous environment of the brain interstitial fluid to exert and ...of drug results into high uptake by the peripheral tissue on ...
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