DSB, DNA double-strand break
Evaluation of Ameliorative Potential of Vitamins E and C on DNA Double Strand Break (DSB) in Patients Undergoing Computed Tomography (CT): A Clinical Study
... of DNA double strand break (DSB) caused by CT ...of DSB was performed using γ-H2AX method as a sensitive ...the DSB (<3%, P ...
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Tying the loose ends together in DNA double strand break repair with 53BP1
... including DNA double-stranded breaks (DSBs), through the activation of DNA damage response signaling ...during DNA replication, or through immunoglobulin heavy chain (IgH) rearrangements in B ...
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Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.
... 2014). DNA DSB repair status, as determined in this study, could potentially be used as a biomarker to identify patients with RAD51 negative tumours who might benefit from DDR modulation during ...
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The Relative Biologic Effectiveness versus Linear Energy Transfer Curve as a Cell Trait
... the DNA double strand break (dsb) repair pathway; and the context is cellular stress responsing to DNA damage by both external stimuli and internal redox ...of DNA ...
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The Drosophila spn-D Gene Encodes a RAD51C-Like Protein That Is Required Exclusively During Meiosis
... in double-strand DNA break (DSB) repair enzymes, such as spn-B, activate a meiotic checkpoint leading to dorsal-ventral patterning defects in the egg and an abnormal appearance of the ...
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Strand Invasion and DNA Synthesis From the Two 3′ Ends of a Double-Strand Break in Mammalian Cells
... vector-borne double-strand break ...involve strand invasion and DNA synthesis by both 3⬘ ends of the ...These DNA interactions are a central, predicted feature of the DSBR model ...
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Transcription and Double-Strand Breaks Induce Similar Mitotic Recombination Events in Saccharomyces cerevisiae
... of double-strand-break (DSB)-induced recombination and sponta- neous recombination under low- and high-transcription conditions in ...and double mutations, consistent with the actual ...
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Capture of DNA Sequences at Double-Strand Breaks in Mammalian Chromosomes
... study double-strand break (DSB)-induced mutations in mammalian chromosomes, we transfected thymidine kinase (tk)-deficient mouse fibroblasts with a DNA substrate containing a ...
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DNA-PK Deficiency in Alzheimer's Disease
... repair; DNA-PK: DNA- dependent protein kinase; DSB: double strand breaks; DSBR: Double strand break repair; HR: Homologous recombination; NER: Nucleotide excision ...
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Erythropoiesis: insights into pathophysiology and treatments in 2017
... DNMT1: DNA-methyl transferase 1; DSB: Double strand break; EPO: Erythropoietin; EPO-R: Erythropoietin receptor; ERFE: Erythroferrone; GvHD: Graft-versus-host disease; HAMP: Hepcidin ...
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Coordination of DNA Ends During Double-Strand-Break Repair in Bacteriophage T4
... the break site, but full recovery of distant and rII mutant phage when coconversion does ...the break site tion can therefore be used to calculate coconversion have indeed been replaced by the corresponding ...
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Meiotic Recombination Involving Heterozygous Large Insertions in Saccharomyces cerevisiae: Formation and Repair of Large, Unpaired DNA Loops
... ble-strand break (DSB) and repair of that break with matched templates can lead to gene conversion or resto- sequences derived from the homologous chromosome ration of Mendelian segregation ...
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Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms
... acute DNA damage response, it appears that a chronic hypoxic response develops whereby important genes in the MMR and HR pathways – including MLH1, MSH2, BRCA1, and Rad51 – are down- regulated ...of DNA ...
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Does age influence loss of heterozygosity?
... missing DNA sequence information for DSB ...in break-induced replication (BIR) the tract extends from the break site all the way to the chromosome ...a DSB can lead to different amounts ...
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Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti tumor effects of the poly (ADP ribose) polymerase (PARP) inhibitor olaparib in triple negative breast cancer cells
... of DNA repair has demon- strated that a synthetic lethal approach involving the use of poly (ADP-ribose) polymerase (PARP) inhibitors is a promising new therapeutic strategy for treating various ...cancers. ...
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Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response
... Netherlands) DNA mini kit. Matched normal DNA was obtained from periph- eral blood and extracted by DNAzol and purified with Qia- gen DNeasy ...in DNA repair, cell cycle, apoptosis, epigenetic ...
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Original Article Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan
... series, DNA damage of biliary epithelial cells due to exposure to organic solvents including 1,2-DCP and/or DCM is supposed to be associated with the carcinogenic process, although the exact mechanism of the ...
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HOW MANY PROCESSED PSEUDOGENES ARE ACCUMULATED IN A GENE FAMILY?
... This observation suggests that a staggered double-strand break is created at the target site in the DNA, with subsequent replication creating duplicated repeats th[r] ...
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DNA damage response and repair in perspective: Aedes aegypti, Drosophila melanogaster and Homo sapiens
... of DNA damage sensors, signal transducers and effectors proteins, and at core of this machinery are the transducer kinases ATM (ataxia telangiectasia mutated), ATR (ATM and Rad3- related) DNAPKcs ...
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Evidence for conservative (two-progeny) DNA double-strand break repair.
... Intramolecular double-strand break repair in the RecE pathway (in a recBC sbcA strain): As our aim is in demonstration of intramolecular recombination and, therefore, cons[r] ...
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